Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Sean Z. Laughlin"'
Autor:
Chunling Yi, Jeremie Vitte, Chan Nguyen, Yuhao Shi, Shannon M. White, Hengye Chen, Saumya R. Bollam, Jeffery A. Toretsky, Garrett T. Graham, Marco Giovannini, Mandheer Wadhwa, Sean Z. Laughlin
Publikováno v:
Developmental cell, vol 39, iss 4
Merlin encoded by the Nf2 gene is a bona fide tumor suppressor that has been implicated in regulation of both the Hippo-Yap and Rac1-Pak1 pathways. Using genetically engineered murine liver models, we show that co-deletion of Rac1 with Nf2 blocks tum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c811fd1e4d302297e2598034d7cb143
https://doi.org/10.1016/j.devcel.2016.09.027
https://doi.org/10.1016/j.devcel.2016.09.027
Autor:
Mandheer Wadhwa, Yuhao Shi, Alias Smith, Swati Gupta, Mark Manzano, Nivedita Nandakumar, Anton Wellstein, Mahandranauth A. Chetram, Jeffrey A. Toretsky, Chunling Yi, Eveline E. Vietsch, Bhaskar Kallakury, Weiying Zhang, Garrett T. Graham, Sean Z. Laughlin, Fen Wang, Mrinmayi Joshi
Publikováno v:
Science Signaling. 7
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer with poor survival rates and frequently carries oncogenic KRAS mutation. However, KRAS has thus far not been a viable therapeutic target. We found that the abundance of YAP mRNA, which e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::866ff989a53af5ecaa555cad018647b4
https://doi.org/10.1126/scisignal.2005049
https://doi.org/10.1126/scisignal.2005049