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Akademický článek

Meiotic protein SYCP2 confers resistance to DNA-damaging agents through R-loop-mediated DNA repair

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)

Abstract Drugs targeting the DNA damage response (DDR) are widely used in cancer therapy, but resistance to these drugs remains a major clinical challenge. Here, we show that SYCP2, a meiotic protein in the synaptonemal complex, is aberrantly and com

Externí odkaz: https://doaj.org/article/fee47f6ec5bd4fda828f917b06a525d3

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Akademický článek

A β2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation

Autor: Carla Guenther, Imrul Faisal, Liisa M. Uotila, Marc Llort Asens, Heidi Harjunpää, Terhi Savinko, Tiina Öhman, Sean Yao, Markus Moser, Stephan W. Morris, Sari Tojkander, Susanna Carola Fagerholm

Publikováno v: Frontiers in Immunology, Vol 10 (2019)

β2-integrins are essential for immune system function because they mediate immune cell adhesion and signaling. Consequently, a loss of β2-integrin expression or function causes the immunodeficiency disorders, Leukocyte Adhesion Deficiency (LAD) typ

Externí odkaz: https://doaj.org/article/d3ea715320a64913a13509074d091f20

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Akademický článek

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Mutations in the cytoplasmic domain of dengue virus NS4A affect virus fitness and interactions with other non-structural proteins

Autor: Sean Yao Zu Kong, Subhash G. Vasudevan, Kitti Wing Ki Chan, Jocelyn Y Jin, Min Jie Alvin Tan, Nancy G Brown

Publikováno v: Journal of General Virology. 101:941-953

The dengue virus (DENV) replication complex is made up of its non-structural (NS) proteins and yet-to-be identified host proteins, but the molecular interactions between these proteins are not fully elucidated. In this work, we sought to uncover the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::468e421b742f7502db7c39ac75ab88a9
https://doi.org/10.1099/jgv.0.001462

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Filamin A Is Required for Optimal T Cell Integrin-Mediated Force Transmission, Flow Adhesion, and T Cell Trafficking

Autor: Liisa M. Uotila, Sean Yao, Susanna C. Fagerholm, Marc Llort Asens, Carla Guenther, Sari Tojkander, Terhi Savinko

Publikováno v: The Journal of Immunology. 200:3109-3116

T cells traffic from the bloodstream into tissues to perform their functions in the immune system and are therefore subjected to a range of different mechanical forces. Integrins are essential for T cell trafficking into the tissues, as they mediate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a8ad872c9ccad39bcd5a4d1e3940d42
https://doi.org/10.4049/jimmunol.1700913

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Akademický článek

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Akademický článek

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A beta 2-Integrin/MRTF-A/SRF Pathway Regulates Dendritic Cell Gene Expression, Adhesion, and Traction Force Generation

Publikováno v: Frontiers in immunology
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology

beta 2-integrins are essential for immune system function because they mediate immune cell adhesion and signaling. Consequently, a loss of beta(2)-integrin expression or function causes the immunodeficiency disorders, Leukocyte Adhesion Deficiency (L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1a7cb364becf89e098807f6bd841fee
https://hdl.handle.net/21.11116/0000-0003-E6EC-021.11116/0000-0003-E6EE-E21.11116/0000-0003-E6EF-D

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Traction Force Screening Enabled by Compliant PDMS Elastomers

Autor: John K. Sullivan, Sean Yao, Li Chuck Z, Mohammad Tabatabaei, Kavitha Rajendran, Newsha Koushki, Allen J. Ehrlicher, Magali Saint-Geniez, Ramaswamy Krishnan, Haruka Yoshie, Amjad Husain, Rosa Kaviani, Quynh Dang

Actomyosin contractility is an essential element of many aspects of cellular biology and manifests as traction forces that cells exert on their surroundings. The central role of these forces makes them a novel principal therapeutic target in diverse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73790f8e6d16e6eaec70ff5ac8107f3
https://europepmc.org/articles/PMC5961466/

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