Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Sean W. Reilly"'
Publikováno v:
ACS Omega, Vol 3, Iss 8, Pp 9997-10001 (2018)
Externí odkaz:
https://doaj.org/article/91b53e19f1fc47d6a8b1f40e56c7f46c
Autor:
Ryan W. Conversano, Robert B. Lobbia, Steven M. Arestie, Alejandro Lopez-Ortega, Vernon H. Chaplin, Sean W. Reilly, Dan M. Goebel
Publikováno v:
Journal of Propulsion and Power. :1-15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea2f7993e87d4be7349f7c9ddd7d2d19
https://doi.org/10.2514/1.b38733
https://doi.org/10.2514/1.b38733
Autor:
Daniel A. Pryma, John M. Maris, Robert H. Mach, Bruce R. Pawel, Roger A. Greenberg, Sean D. Carlin, Kuiying Xu, Daniel Martinez, Pichai Raman, Catherine Hou, Ho Sze Chan, Chi-Chang Weng, Komal S. Rathi, Sean W. Reilly, Laura N. Puentes, Hwan Lee, Mehran Makvandi
SI Figure 1: Reaction scheme for synthesizing 1-(4-astatophenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one ([211At]MM4) from tin precursor 1-(4-(tributylstannyl)phenyl)-8,9-dihydro-2,7,9a-triazabenzo[cd]azulen-6(7H)-one; SI Figure 2: Reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::119714469e6f6f337985a31a1b82ffd9
https://doi.org/10.1158/1535-7163.22506018
https://doi.org/10.1158/1535-7163.22506018
Publikováno v:
Molecular Neurobiology. 58:3641-3652
Repurposing PARP-1 inhibitors (PARPi) for non-oncological applications offers an attractive therapeutic strategy for pathological conditions characterized by PARP-1 hyperactivity. In the context of Parkinson's disease (PD), PARP-1 hyperactivity has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee1f7d11e14c1d9fdc25340fd4575beb
https://doi.org/10.1007/s12035-021-02371-4
https://doi.org/10.1007/s12035-021-02371-4
Autor:
Andrew Ruff, Daniel A. Jacome, Justin D. Northrup, Sean W Reilly, Mark A. Sellmyer, Gabrielle S Blizard, Iris Lee
Publikováno v:
ACS Chem Biol
Cell-cell interactions and communication are crucial to the proper function of complex mammalian physiology including neurocognitive and immune system functions. While many tools are available for observing and perturbing intracellular processes, rel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4176866dffb6233b6ec8e8cfaf8efe2d
https://doi.org/10.1021/acschembio.0c00935
https://doi.org/10.1021/acschembio.0c00935
Autor:
Sean W. Reilly, Robert H. Mach
Publikováno v:
Handbook of Radiopharmaceuticals
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81f8b6c43eeb60fc8099374dc3d6d634
https://doi.org/10.1002/9781119500575.ch10
https://doi.org/10.1002/9781119500575.ch10
Publikováno v:
Chemistry – A European Journal. 26:4251-4255
A late-stage 18 O labeling approach of sulfonamides that employs the corresponding unlabeled molecule as the starting material was developed. Upon deamination of the sulfonamide, a sulfinate intermediate was isotopically enriched using eco-friendly r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::204522549254bc1c5df1e2ffc0fb46a1
https://doi.org/10.1002/chem.202000484
https://doi.org/10.1002/chem.202000484
Improved production of 76Br, 77Br and 80mBr via CoSe cyclotron targets and vertical dry distillation
Autor:
Bryan Bednarz, Sean W. Reilly, Aeli P. Olson, Dhanabalan Murali, Jennifer L. Bartels, Paul A. Ellison, Robert J. Nickles, Jonathan W. Engle, Mehran Makvandi, Todd E. Barnhart, Robert H. Mach, Onofre T. DeJesus, Sabrina Hoffman, Suzanne E. Lapi
Publikováno v:
Nucl Med Biol
INTRODUCTION: The radioisotopes of bromine are uniquely suitable radiolabels for small molecule theranostic radiopharmaceuticals but are of limited availability due to production challenges. Significantly improved methods were developed for the produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e25055fcefb5c2ca5371febe099843b5
https://doi.org/10.1016/j.nucmedbio.2019.09.001
https://doi.org/10.1016/j.nucmedbio.2019.09.001
Autor:
Mehran Makvandi, Hwan Lee, Robert H. Mach, John M. Maris, Daniel Martinez, Pichai Raman, Roger A. Greenberg, Kuiying Xu, Chi-Chang Weng, Catherine Hou, Sean D. Carlin, Sean W. Reilly, Ho Sze Chan, Laura N. Puentes, Komal S. Rathi, Daniel A. Pryma, Bruce R. Pawel
Publikováno v:
Mol Cancer Ther
Alpha-emitters can be pharmacologically delivered for irradiation of single cancer cells, but cellular lethality could be further enhanced by targeting alpha-emitters directly to the nucleus. PARP-1 is a druggable protein in the nucleus that is overe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e75e9114da8d8ff6f2f78abc8bd2443
https://doi.org/10.1158/1535-7163.mct-18-0837
https://doi.org/10.1158/1535-7163.mct-18-0837
Autor:
Chia-Ju Hsieh, Chi-Chang Weng, Robert R. Luedtke, John Karanicolas, Shipra Malhotra, Daniel A. Jacome, Robert H. Mach, Kuiying Xu, Suzy A. Griffin, Kristoffer Sahlholm, Michelle Taylor, Sean W. Reilly, Christopher Parry, Nathan Kirschner, Aladdin Riad
Publikováno v:
Journal of Medicinal Chemistry. 62:5132-5147
Previously, we reported a 3-(2-methoxyphenyl)-9-(3-((4-methyl-5-phenyl-4 H-1,2,4-triazol-3-yl)thio)propyl)-3,9-diazaspiro[5.5]undecane (1) compound with excellent dopamine D3 receptor (D3R) affinity (D3R Ki = 12.0 nM) and selectivity (D2R/D3R ratio =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52cdb48cd88d3eff4b1bcdc4843028f
https://doi.org/10.1021/acs.jmedchem.9b00412
https://doi.org/10.1021/acs.jmedchem.9b00412