Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Sean W Clark"'
Autor:
Nicole K Polinski, Terina N Martinez, Alexander Gorodinsky, Ralph Gareus, Michael Sasner, Mark Herberth, Robert Switzer, Syed O Ahmad, Mali Cosden, Monika Kandebo, Robert E Drolet, Peter D Buckett, Weisong Shan, Yi Chen, Lee J Pellegrino, Gregory D Ellsworth, Leo B Dungan, Warren D Hirst, Sean W Clark, Kuldip D Dave
Publikováno v:
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically b
Externí odkaz:
https://doaj.org/article/294b88f9cc54498d84ccf437a6bd2775
Autor:
Nicole K. Polinski, Terina N. Martinez, Sylvie Ramboz, Michael Sasner, Mark Herberth, Robert Switzer, Syed O. Ahmad, Lee J. Pelligrino, Sean W. Clark, Jacob N. Marcus, Sean M. Smith, Kuldip D. Dave, Mark A. Frasier
Publikováno v:
Disease Models & Mechanisms, Vol 15, Iss 6 (2022)
Heterozygous mutations in the GBA1 gene – encoding lysosomal glucocerebrosidase (GCase) – are the most common genetic risk factors for Parkinson's disease (PD). Experimental evidence suggests a correlation between decreased GCase activity and acc
Externí odkaz:
https://doaj.org/article/2ff4a4f7438a460f8a91ec3fc7c58bc4
Autor:
Lee Pellegrino, Monika Kandebo, Nicole K. Polinski, Mark Herberth, Leo B. Dungan, Robert Switzer, Gregory D. Ellsworth, Sean W. Clark, Alexander Gorodinsky, Robert E. Drolet, Peter D. Buckett, Mali Cosden, Michael Sasner, Ralph Gareus, Syed Omar Ahmad, Weisong Shan, Terina N. Martinez, Kuldip D. Dave, Warren D. Hirst, Yi Chen
Publikováno v:
PLoS ONE
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
PLoS ONE, Vol 16, Iss 6, p e0252325 (2021)
Multiple mutations have been described in the human GBA1 gene, which encodes the lysosomal enzyme beta-glucocerebrosidase (GCase) that degrades glucosylceramide and is pivotal in glycosphingolipid substrate metabolism. Depletion of GCase, typically b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5768efebed44f52b94d2247e7ec2bf9
http://europepmc.org/articles/PMC8189458
http://europepmc.org/articles/PMC8189458
Autor:
Leo B. Dungan, Hui H. Chang, Sean W. Clark, Nastry Brignol, Michelle Frascella, Kenneth J. Valenzano, Richie Khanna, Elfrida R. Benjamin, Robert Boyd, Rick Hamler, Sean Morrison
Publikováno v:
Analytical Chemistry. 89:8288-8295
Gaucher disease (GD) is caused by mutations in the GBA1 gene that encodes the lysosomal enzyme acid β-glucosidase (GCase). Reduced GCase activity primarily leads to the accumulation of two substrates, glucosylceramide (GlcCer) and glucosylsphingosin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e69e1fa18dc483218406547e0df9d4e
https://doi.org/10.1021/acs.analchem.7b01442
https://doi.org/10.1021/acs.analchem.7b01442
Autor:
David J. Lockhart, Sindalana Hean, Lee Pellegrino, Sheila M. Fleming, Melanie B. Watson, Farzad Mortazavi, Franziska Richter, Caitlin K. Mulligan, Brian Ranes, Chunni Zhu, Richie Khanna, John J. Flanagan, Sean W. Clark, Pedrom C. Sioshansi, Krystal De La Rosa, Vincent Lemesre, Brandon Wustman, Marie-Françoise Chesselet
Publikováno v:
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, vol 11, iss 4
Mutation of the lysosomal hydrolase acid-β-glucosidase (GCase), which leads to reduced GCase activity, is one of the most frequent genetic risk factors for Parkinson's disease (PD) and promotes α-synuclein accumulation in the brain, a hallmark of P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9efd5833a91243954673e6041ea0a90d
https://doi.org/10.1007/s13311-014-0294-x
https://doi.org/10.1007/s13311-014-0294-x
Publikováno v:
Proceedings of the National Academy of Sciences. 99:1353-1358
Pentamer formation by Vp1, the major capsid protein of simian virus 40, requires an interdigitation of structural elements from the Vp1 monomers [Liddington, R. C., Yan, Y., Moulai, J., Sahli, R., Benjamin, T. L. & Harrison, S. C. (1991) Nature (Lond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb171d83d11358615440fbffd09982d5
https://doi.org/10.1073/pnas.032668699
https://doi.org/10.1073/pnas.032668699
Autor:
Sean W. Clark, Erika L. F. Holzbaur, Bryce Mark Paschal, Olivier Staub, Richard B. Vallee, David I. Meyer, Imran B. Clark
Publikováno v:
Molecular Biology of the Cell. 5:1301-1310
An examination of human-expressed sequence tags indicated the existence of an isoform of centractin, an actin-related protein localized to microtubule-associated structures. Using one of these tags, we isolated and determined the nucleotide sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::697558adaefa2303072e95dc1fba9dca
https://doi.org/10.1091/mbc.5.12.1301
https://doi.org/10.1091/mbc.5.12.1301
Autor:
David I. Meyer, Sean W. Clark
Publikováno v:
The Journal of Cell Biology
The Journal of cell biology, vol 127, iss 1
The Journal of cell biology, vol 127, iss 1
As part of our ongoing efforts to understand the functional role of vertebrate centractins, we have identified a new member of the actin-related family of proteins in the yeast Saccharomyces cerevisiae using a PCR-based approach. Consistent with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e722eb1372499af0cd4f903d145390aa
http://europepmc.org/articles/PMC2120173
http://europepmc.org/articles/PMC2120173
Autor:
Sean W. Clark, Erika L. F. Holzbaur, David I. Meyer, K. Kevin Pfister, Richard B. Vallee, Bryce M. Paschal
Publikováno v:
Journal of Biological Chemistry. 268:15318-15323
Earlier work identified a series of accessory polypeptides of 150, 74, 59, 57, 55, 53, 50, and 45 kDa copurifying with cytoplasmic dynein. In the present study immunoprecipitation of the 50-kDa polypeptide from bovine brain cytosol with a specific mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::eaa85172bfa1468362c7c87d81c7a0c9
https://doi.org/10.1016/s0021-9258(18)82472-3
https://doi.org/10.1016/s0021-9258(18)82472-3
Autor:
Sean W. Clark, David I. Meyer
Publikováno v:
Nature. 359:246-250
ACTIN is one of the most ubiquitous, abundant and well-conserved proteins of eukaryotes, participating in many crucial cellular processes including the maintenance of cell shape, motility and cell division1,2. Actins from the most divergent sources s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::203e57dcfd90f9f7f106eedad2ad3344
https://doi.org/10.1038/359246a0
https://doi.org/10.1038/359246a0