Model comparison via simplicial complexes and persistent homology

Autor: Sean T. Vittadello, Michael P. H. Stumpf

Publikováno v: Royal Society Open Science, Vol 8, Iss 10 (2021)

In many scientific and technological contexts, we have only a poor understanding of the structure and details of appropriate mathematical models. We often, therefore, need to compare different models. With available data we can use formal statistical

Externí odkaz: https://doaj.org/article/b98996487bc64752a237f3e347dc854a

A group theoretic approach to model comparison with simplicial representations

Autor: Sean T. Vittadello, Michael P. H. Stumpf

Publikováno v: Journal of mathematical biology. 85(5)

The complexity of biological systems, and the increasingly large amount of associated experimental data, necessitates that we develop mathematical models to further our understanding of these systems. As biological systems are generally not well unde

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7826f65b7c61957b5308cf3e324192d5
https://pubmed.ncbi.nlm.nih.gov/36209430

Bayesian and Algebraic Strategies to Design in Synthetic Biology

Autor: Robyn P. Araujo, Sean T. Vittadello, Michael P. H. Stumpf

Innovation in synthetic biology often still depends on large-scale experimental trial-and-error, domain expertise, and ingenuity. The application of rational design engineering methods promise to make this more efficient, faster, cheaper and safer. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::159395ab377808de59a2f427386e76d8

Synchronised oscillations in growing cell populations are explained by demographic noise

Autor: Christian A. Yates, Gency Gunasingh, Enrico Gavagnin, Matthew J. Simpson, Tim Rogers, Nikolas K. Haass, Sean T. Vittadello

Publikováno v: Yates, K, Gavagnin, E, Rogers, T, Simpson, M, Haass, N, Vittadello, S & Gunasingh, G 2021, ' Synchronised oscillations in growing cell populations are explained by demographic noise ', Biophysical Journal . https://doi.org/10.1016/j.bpj.2021.02.017
Biophys J

Understanding synchrony in growing populations is important for applications as diverse as epidemiology and cancer treatment. Recent experiments employing fluorescent reporters in melanoma cell lines have uncovered growing subpopulations exhibiting s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2c75aa710e526c9b7db421a4f20b060

Practical parameter identifiability for spatio-temporal models of cell invasion

Autor: Sean T. Vittadello, Ruth E. Baker, Oliver J. Maclaren, Matthew J. Simpson

Publikováno v: J R Soc Interface

We examine the practical identifiability of parameters in a spatio-temporal reaction–diffusion model of a scratch assay. Experimental data involve fluorescent cell cycle labels, providing spatial information about cell position and temporal informa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2daf08ad309e1707bf2030a83163714
https://pubmed.ncbi.nlm.nih.gov/32126193