Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Sean S. Keating"'
Autor:
Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitati
Externí odkaz:
https://doaj.org/article/4c4d2aa5f2d24e1cbc0429058653faa3
Publikováno v:
Cellular and Molecular Life Sciences. 80
Aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43-related neurodegeneration involves multiple changes to normal physiological TDP-43, which undergoes nuclear
Dysfunction and aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Mechanisms and relative contributions of concurrent TDP-43 nuclear depletion, cytoplasm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d43878bb5359b1ef33f25db5da166df3
https://doi.org/10.1101/2022.09.06.506721
https://doi.org/10.1101/2022.09.06.506721
Autor:
Hossai Gul, Roger S. Chung, Owen Watson, Thomas J. Hedl, Paul A. Della Gatta, Sean S. Keating, Britt A. Berning, Adam K. Walker, Winonah R. Riddell, Julie D. Atkin, Catherine A. Blizzard, Kelly R. Jacobs, Bingyang Shi, Marco Morsch, Amanda L. Wright, Rebecca San Gil, Albert Lee, Sheng Le, Prachi Mehta, Juliana Venturato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e45cf72ad3d3e91e813216eaafa789
https://doi.org/10.1111/ejn.15422/v2/response1
https://doi.org/10.1111/ejn.15422/v2/response1
Autor:
Adam K. Walker, Rebecca San Gil, Thomas J. Hedl, Paul A. Della Gatta, Catherine A. Blizzard, Britt A. Berning, Sean S. Keating, Roger S. Chung, Amanda L. Wright, Bingyang Shi, Albert Lee, Winonah R. Riddell, Kelly R. Jacobs, Julie D. Atkin, Sheng Le, Prachi Mehta, Marco Morsch, Juliana Venturato, Hossai Gul, Owen Watson
Publikováno v:
The European journal of neuroscienceREFERENCES. 54(6)
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission. However, riluzole only modestly extends lifespan for people living wit
Autor:
Paul A. Della Gatta, Winonah R. Riddell, Juliana Venturato, Roger S. Chung, Amanda L. Wright, Kelly R. Jacobs, Thomas J. Hedl, Hossai Gul, Rebecca San Gil, Albert Lee, Owen Watson, Bingyang Shi, Britt A. Berning, Julie D. Atkin, Marco Morsch, Catherine A. Blizzard, Sean S. Keating, Sheng Le, Prachi Mehta, Adam K. Walker
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease commonly treated with riluzole, a small molecule that may act via modulation of glutamatergic neurotransmission. However, riluzole only modestly extends lifespan for people living wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69a0413f7a966d67c76993e2597d6262
Autor:
Livesey JA; Edinburgh Critical Care Research Group, Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Lone N; Edinburgh Critical Care Research Group, Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Black E; Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Broome R; Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Syme A; Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Keating S; Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Elliott L; Department of Critical Care, Victoria Hospital Kirkcaldy, Kirkcaldy, UK., McCahill C; Department of Critical Care, Victoria Hospital Kirkcaldy, Kirkcaldy, UK., Simpson G; Department of Critical Care, Victoria Hospital Kirkcaldy, Kirkcaldy, UK., Grant H; Department of Critical Care, St John's Hospital, Livingston, UK., Auld F; Department of Critical Care, Western General Hospital, Edinburgh, UK., Garrioch S; Department of Critical Care, Borders General Hospital, Melrose, UK., Hay A; Edinburgh Critical Care Research Group, Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK., Craven TH; Edinburgh Critical Care Research Group, Department of Critical Care, Royal Infirmary of Edinburgh, Edinburgh, UK.
Publikováno v:
Journal of the Intensive Care Society [J Intensive Care Soc] 2023 Dec 21; Vol. 25 (2), pp. 131-139. Date of Electronic Publication: 2023 Dec 21 (Print Publication: 2024).
Autor:
Pairo-Castineira E; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Rawlik K; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Bretherick AD; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Pain Service, NHS Tayside, Ninewells Hospital and Medical School, Dundee, UK., Qi T; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Nassiri I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., McConkey GA; Faculty of Biological Sciences, University of Leeds, Leeds, UK., Zechner M; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Klaric L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Griffiths F; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Oosthuyzen W; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Kousathanas A; Genomics England, London, UK., Richmond A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Millar J; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Russell CD; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Malinauskas T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Thwaites R; National Heart and Lung Institute, Imperial College London, London, UK., Morrice K; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Keating S; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Maslove D; Department of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada., Nichol A; Clinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Semple MG; NIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool, Liverpool, UK.; Respiratory Medicine, Alder Hey Children's Hospital, Institute in The Park, University of Liverpool, Alder Hey Children's Hospital, Liverpool, UK., Knight J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Shankar-Hari M; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Summers C; Department of Medicine, University of Cambridge, Cambridge, UK., Hinds C; William Harvey Research Institute Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Horby P; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ling L; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China., McAuley D; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Department of Intensive Care Medicine, Royal Victoria Hospital, Belfast, UK., Montgomery H; UCL Centre for Human Health and Performance, London, UK., Openshaw PJM; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Begg C; Royal Hospital for Children, Glasgow, UK., Walsh T; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Tenesa A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Flores C; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.; Research Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain.; Centre for Biomedical Network Research on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.; Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain., Riancho JA; IDIVAL, Santander, Spain.; Universidad de Cantabria, Santander, Spain.; Hospital U M Valdecilla, Santander, Spain., Rojas-Martinez A; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud and Hospital San Jose TecSalud, Monterrey, Mexico., Lapunzina P; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-IDIPAZ, Madrid, Spain.; ERN-ITHACA-European Reference Network, Paris, France., Yang J; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Ponting CP; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Abedalthagafi M; Genomic Research Department, King Fahad Medical City, Riyadh, Saudi Arabia.; Department of Pathology & Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA., Luchessi AD; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Cruz R; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Carracedo A; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica, Sistema Galego de Saúde (SERGAS) Santiago de Compostela, Santiago de Compostela, Spain., Fawkes A; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Murphy L; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Rowan K; Intensive Care National Audit & Research Centre, London, UK., Pereira AC; Heart Institute, University of Sao Paulo, Butanta, Brazil., Law A; Roslin Institute, University of Edinburgh, Edinburgh, UK., Fairfax B; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Hendry SC; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Baillie JK; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK. j.k.baillie@ed.ac.uk.; Roslin Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.
Publikováno v:
Nature [Nature] 2023 Jul; Vol. 619 (7971), pp. E61.
Autor:
Pairo-Castineira E; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Rawlik K; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Bretherick AD; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Pain Service, NHS Tayside, Ninewells Hospital and Medical School, Dundee, UK., Qi T; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Nassiri I; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., McConkey GA; Faculty of Biological Sciences, University of Leeds, Leeds, UK., Zechner M; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Klaric L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Griffiths F; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Oosthuyzen W; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Kousathanas A; Genomics England, London, UK., Richmond A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Millar J; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Russell CD; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Malinauskas T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Thwaites R; National Heart and Lung Institute, Imperial College London, London, UK., Morrice K; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Keating S; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Maslove D; Department of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada., Nichol A; Clinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Semple MG; NIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences University of Liverpool, Liverpool, UK.; Respiratory Medicine, Alder Hey Children's Hospital, Institute in The Park, University of Liverpool, Alder Hey Children's Hospital, Liverpool, UK., Knight J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Shankar-Hari M; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK.; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Summers C; Department of Medicine, University of Cambridge, Cambridge, UK., Hinds C; William Harvey Research Institute Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Horby P; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ling L; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China., McAuley D; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Department of Intensive Care Medicine, Royal Victoria Hospital, Belfast, UK., Montgomery H; UCL Centre for Human Health and Performance, London, UK., Openshaw PJM; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust, London, UK., Begg C; Royal Hospital for Children, Glasgow, UK., Walsh T; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Tenesa A; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Flores C; Genomics Division, Instituto Tecnológico y de Energías Renovables, Santa Cruz de Tenerife, Spain.; Research Unit, Hospital Universitario N.S. de Candelaria, Santa Cruz de Tenerife, Spain.; Centre for Biomedical Network Research on Respiratory Diseases (CIBERES), Instituto de Salud Carlos III, Madrid, Spain.; Department of Clinical Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain., Riancho JA; IDIVAL, Santander, Spain.; Universidad de Cantabria, Santander, Spain.; Hospital U M Valdecilla, Santander, Spain., Rojas-Martinez A; Tecnologico de Monterrey, Escuela de Medicina y Ciencias de la Salud and Hospital San Jose TecSalud, Monterrey, Mexico., Lapunzina P; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Instituto de Genética Médica y Molecular (INGEMM), Hospital Universitario La Paz-IDIPAZ, Madrid, Spain.; ERN-ITHACA-European Reference Network, Paris, France., Yang J; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Ponting CP; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Abedalthagafi M; Genomic Research Department, King Fahad Medical City, Riyadh, Saudi Arabia.; Department of Pathology & Laboratory Medicine, Emory University Hospital, Atlanta, GA, USA., Luchessi AD; Department of Clinical Analysis and Toxicology, Federal University of Rio Grande do Norte, Natal, Brazil.; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Parra EJ; Department of Anthropology, University of Toronto at Mississauga, Mississauga, Ontario, Canada., Cruz R; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain., Carracedo A; Centre for Biomedical Network Research on Rare Diseases (CIBERER), Instituto de Salud Carlos III, Madrid, Spain.; Centro Singular de Investigación en Medicina Molecular y Enfermedades Crónicas (CIMUS), Universidade de Santiago de Compostela, Santiago de Compostela, Spain.; Instituto de Investigación Sanitaria de Santiago (IDIS), Santiago de Compostela, Spain.; Fundación Pública Galega de Medicina Xenómica, Sistema Galego de Saúde (SERGAS) Santiago de Compostela, Santiago de Compostela, Spain., Fawkes A; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Murphy L; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Rowan K; Intensive Care National Audit & Research Centre, London, UK., Pereira AC; Heart Institute, University of Sao Paulo, Butanta, Brazil., Law A; Roslin Institute, University of Edinburgh, Edinburgh, UK., Fairfax B; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Hendry SC; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK.; Roslin Institute, University of Edinburgh, Edinburgh, UK., Baillie JK; Baillie Gifford Pandemic Science Hub, Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK. j.k.baillie@ed.ac.uk.; Roslin Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.
Publikováno v:
Nature [Nature] 2023 May; Vol. 617 (7962), pp. 764-768. Date of Electronic Publication: 2023 May 17.
Autor:
Kousathanas A; Genomics England, London, UK., Pairo-Castineira E; Roslin Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Rawlik K; Roslin Institute, University of Edinburgh, Edinburgh, UK., Stuckey A; Genomics England, London, UK., Odhams CA; Genomics England, London, UK., Walker S; Genomics England, London, UK., Russell CD; Roslin Institute, University of Edinburgh, Edinburgh, UK.; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK., Malinauskas T; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Wu Y; Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland, Australia., Millar J; Roslin Institute, University of Edinburgh, Edinburgh, UK., Shen X; Biostatistics Group, Greater Bay Area Institute of Precision Medicine (Guangzhou), Fudan University, Guangzhou, China.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Elliott KS; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Griffiths F; Roslin Institute, University of Edinburgh, Edinburgh, UK., Oosthuyzen W; Roslin Institute, University of Edinburgh, Edinburgh, UK., Morrice K; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Keating S; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Wang B; Roslin Institute, University of Edinburgh, Edinburgh, UK., Rhodes D; Genomics England, London, UK., Klaric L; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Zechner M; Roslin Institute, University of Edinburgh, Edinburgh, UK., Parkinson N; Roslin Institute, University of Edinburgh, Edinburgh, UK., Siddiq A; Genomics England, London, UK., Goddard P; Genomics England, London, UK., Donovan S; Genomics England, London, UK., Maslove D; Department of Critical Care Medicine, Queen's University and Kingston Health Sciences Centre, Kingston, Ontario, Canada., Nichol A; Clinical Research Centre at St Vincent's University Hospital, University College Dublin, Dublin, Ireland., Semple MG; NIHR Health Protection Research Unit for Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.; Respiratory Medicine and Institute in the Park, Alder Hey Children's Hospital and University of Liverpool, Liverpool, UK., Zainy T; Genomics England, London, UK., Maleady-Crowe F; Genomics England, London, UK., Todd L; Genomics England, London, UK., Salehi S; Genomics England, London, UK., Knight J; Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK., Elgar G; Genomics England, London, UK., Chan G; Genomics England, London, UK., Arumugam P; Genomics England, London, UK., Patch C; Genomics England, London, UK., Rendon A; Genomics England, London, UK., Bentley D; Illumina Cambridge, Great Abington, UK., Kingsley C; Illumina Cambridge, Great Abington, UK., Kosmicki JA; Regeneron Genetics Center, Tarrytown, NY, USA., Horowitz JE; Regeneron Genetics Center, Tarrytown, NY, USA., Baras A; Regeneron Genetics Center, Tarrytown, NY, USA., Abecasis GR; Regeneron Genetics Center, Tarrytown, NY, USA., Ferreira MAR; Regeneron Genetics Center, Tarrytown, NY, USA., Justice A; Geisinger, Danville, PA, USA., Mirshahi T; Geisinger, Danville, PA, USA., Oetjens M; Geisinger, Danville, PA, USA., Rader DJ; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Ritchie MD; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Verma A; Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA., Fowler TA; Genomics England, London, UK.; Test and Trace, the Health Security Agency, Department of Health and Social Care, London, UK., Shankar-Hari M; Department of Intensive Care Medicine, Guy's and St Thomas' NHS Foundation Trust, London, UK., Summers C; Department of Medicine, University of Cambridge, Cambridge, UK., Hinds C; William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK., Horby P; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Ling L; Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong, China., McAuley D; Wellcome-Wolfson Institute for Experimental Medicine, Queen's University Belfast, Belfast, UK.; Department of Intensive Care Medicine, Royal Victoria Hospital, Belfast, UK., Montgomery H; UCL Centre for Human Health and Performance, London, UK., Openshaw PJM; National Heart and Lung Institute, Imperial College London, London, UK.; Imperial College Healthcare NHS Trust: London, London, UK., Elliott P; Imperial College, London, UK., Walsh T; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK., Tenesa A; Roslin Institute, University of Edinburgh, Edinburgh, UK.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Fawkes A; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Murphy L; Edinburgh Clinical Research Facility, Western General Hospital, University of Edinburgh, Edinburgh, UK., Rowan K; Intensive Care National Audit and Research Centre, London, UK., Ponting CP; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Vitart V; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Wilson JF; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK.; Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, Edinburgh, UK., Yang J; School of Life Sciences, Westlake University, Hangzhou, China.; Westlake Laboratory of Life Sciences and Biomedicine, Hangzhou, China., Bretherick AD; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK., Scott RH; Genomics England, London, UK.; Great Ormond Street Hospital, London, UK., Hendry SC; Roslin Institute, University of Edinburgh, Edinburgh, UK., Moutsianas L; Genomics England, London, UK., Law A; Roslin Institute, University of Edinburgh, Edinburgh, UK., Caulfield MJ; Genomics England, London, UK. m.j.caulfield@qmul.ac.uk.; William Harvey Research Institute, Queen Mary University of London, London, UK. m.j.caulfield@qmul.ac.uk., Baillie JK; Roslin Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.; MRC Human Genetics Unit, Institute of Genetics and Cancer, University of Edinburgh, Western General Hospital, Edinburgh, UK. j.k.baillie@ed.ac.uk.; Centre for Inflammation Research, The Queen's Medical Research Institute, University of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.; Intensive Care Unit, Royal Infirmary of Edinburgh, Edinburgh, UK. j.k.baillie@ed.ac.uk.
Publikováno v:
Nature [Nature] 2022 Jul; Vol. 607 (7917), pp. 97-103. Date of Electronic Publication: 2022 Mar 07.