Regioisomeric SCFA Attachment to Hexosamines Separates Metabolic Flux from Cytotoxicity and MUC1 Suppression

Autor: Christopher Weier, Sean S. Choi, Christopher T. Campbell, Udayanath Aich, Kevin J. Yarema, Noha Elmouelhi, S.-Gopalan Sampathkumar

Publikováno v: ACS Chemical Biology. 3:230-240

Chemical biology studies, exemplified by metabolic glycoengineering experiments that employ short chain fatty acid (SCFA)-hexosamine monosaccharide hybrid molecules, often suffer from off-target effects. Here we demonstrate that systematic structure-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a8b681d9d0e0845e3ce414f39046113
https://doi.org/10.1021/cb7002708

Targeting Pro-Invasive Oncogenes with Short Chain Fatty Acid-Hexosamine Analogs Inhibits the Mobility of Metastatic MDA-MB-231 Breast Cancer Cells

Autor: Mary M. Wen, Sean S. Choi, Katharina Maisel, Udayanath Aich, Jean J. Wang, Srinivasa-Gopalan Sampathkumar, Kevin J. Yarema, Christopher T. Campbell, Christopher Weier

Per-butanoylated N-acetyl-D-mannosamine (Bu(4)ManNAc), a SCFA-hexosamine cancer drug candidate with activity manifest through intact n-butyrate-carbohydrate linkages, reduced the invasion of metastatic MDA-MB-231 breast cancer cells unlike per-butano

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfbb5bbf7dedcad9973b97954656902c
https://europepmc.org/articles/PMC2657678/

Essential role of N-terminal SAM regions in STIM1 multimerization and function.

Autor: Sallinger M; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Humer C; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Ong HL; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Narayanasamy S; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Lin QT; Department of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada., Fahrner M; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Grabmayr H; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Berlansky S; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Choi S; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Schmidt T; Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria., Maltan L; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Atzgerstorfer L; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Niederwieser M; Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria., Frischauf I; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Romanin C; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Stathopulos PB; Department of Physiology and Pharmacology, Western University, London, ON N6A5C1, Canada., Ambudkar I; Secretory Physiology Section, National Institute of Dental and Craniofacial Research, NIH, Bethesda, MD 20892., Leitner R; Institute of Biophysics, Johannes Kepler University Linz, Linz 4040, Austria., Bonhenry D; Department of Physics and Materials Science, Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette L1511, Luxembourg., Schindl R; Department of Medical Physics and Biophysics, Medical University of Graz, Graz 8010, Austria.

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2024 May 21; Vol. 121 (21), pp. e2318874121. Date of Electronic Publication: 2024 May 16.

Site-directed fluorescence studies of a prokaryotic ClC antiporter.

Autor: Bell SP; Membrane Transport Biophysics Unit, Porter Neuroscience Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892, USA., Curran PK, Choi S, Mindell JA

Publikováno v: Biochemistry [Biochemistry] 2006 Jun 06; Vol. 45 (22), pp. 6773-82.