Bioorthogonal chemistry

Autor: Samuel L. Scinto, Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu, Christopher W. am Ende, M. G. Finn, Kathrin Lang, Qing Lin, John Paul Pezacki, Jennifer A. Prescher, Marc S. Robillard, Joseph M. Fox

Publikováno v: Nature reviews. Methods primers, vol 1, iss 1
Nat Rev Methods Primers

Bioorthogonal chemistry represents a class of high-yielding chemical reactions that proceed rapidly and selectively in biological environments without side reactions towards endogenous functional groups. Rooted in the principles of physical organic c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a95e8ad3a2982ea4f321d91e24c1f35d
https://doi.org/10.1038/s43586-021-00028-z

Butenolide Synthesis from Functionalized Cyclopropenones

Autor: Sean S Nguyen, Jennifer A. Prescher, Robert S Dorn, R. David Row, Zane G Long, Tyler K. Heiss, Andrew J. Ferreira

Publikováno v: Org Lett
Organic letters, vol 21, iss 21

A general method to synthesize substituted butenolides from hydroxymethylcyclopropenones is reported. Functionalized cyclopropenones undergo ring-opening reactions with catalytic amounts of phosphine, forming reactive ketene ylides. These intermediat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6f7dfdeed9e63fa1449b8a703bff52
https://pubmed.ncbi.nlm.nih.gov/31622107

Synthesis and Chemical Reactivity of a 6-Me-3,2-Hydroxypyridinone Dithiazolide with Primary Amines: A route to New Hexadentate Chelators for Hard Metal(III) Ions

Autor: Stephanie Zhou, Sean S Nguyen, Marisa E. Hom, Michelle N. Keyser, Sylvie Pailloux, Danil E. Smiles, Kenneth N. Raymond

Publikováno v: Journal of Heterocyclic Chemistry. 53:1065-1073

A hydroxypyridinone building block, bifunctionalized with thiazoline, has been prepared from orthogonally protected 2-(3-(benzyloxy)-4-(ethoxycarbonyl)-6-methyl-2-oxopyridin-1(2H)-yl) acetic acid. The reactivity of the dithiazolide has been explored

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d3e97d28945b53731910e1d8d6552731
https://doi.org/10.1002/jhet.2372

Right ventricular functional recovery assessment with stress echocardiography and cardiopulmonary exercise testing after pulmonary embolism: a pilot prospective multicentre study.

Autor: Samaranayake CB; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK c.samaranayake@uq.net.au.; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia., Upham J; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Princess Alexandra Hospital, Woolloongabba, Queensland, Australia., Tran K; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Department of Respiratory Medicine, Logan Hospital, Loganholme, Queensland, Australia., Howard LS; National Pulmonary Hypertension Service, Hammersmith Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Nguyen S; Princess Alexandra Hospital, Woolloongabba, Queensland, Australia., Lwin M; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK., Anderson J; Sunshine Coast University Hospital, Sunshine Coast, Queensland, Australia., Wahi S; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Princess Alexandra Hospital, Woolloongabba, Queensland, Australia., Price LC; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Wort S; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Li W; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., McCabe C; National Pulmonary Hypertension Service, Royal Brompton Hospital, London, UK.; National Heart and Lung Institute, Imperial College London, London, UK., Keir GJ; Faculty of Medicine, The University of Queensland, Brisbane, Queensland, Australia.; Princess Alexandra Hospital, Woolloongabba, Queensland, Australia.

Publikováno v: BMJ open respiratory research [BMJ Open Respir Res] 2023 Jul; Vol. 10 (1).

Bioorthogonal chemistry.

Autor: Scinto SL; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA., Bilodeau DA; Department of Chemistry and Biomolecular Science, University of Ottawa, Ottawa, Ontario, Canada.; These authors contributed equally: Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu., Hincapie R; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.; These authors contributed equally: Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu., Lee W; Pfizer Worldwide Research and Development, Cambridge, MA, USA.; These authors contributed equally: Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu., Nguyen SS; Department of Chemistry, University of California, Irvine, CA, USA.; These authors contributed equally: Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu., Xu M; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA.; These authors contributed equally: Didier A. Bilodeau, Robert Hincapie, Wankyu Lee, Sean S. Nguyen, Minghao Xu., Am Ende CW; Pfizer Worldwide Research and Development, Groton, CT, USA., Finn MG; School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA, USA., Lang K; Department of Chemistry, Technical University of Munich, Garching, Germany.; Laboratory of Organic Chemistry, ETH Zurich, Zurich, Switzerland., Lin Q; Department of Chemistry, State University of New York at Buffalo, Buffalo, NY, USA., Pezacki JP; Department of Chemistry and Biomolecular Science, University of Ottawa, Ottawa, Ontario, Canada., Prescher JA; Department of Chemistry, University of California, Irvine, CA, USA.; Molecular Biology & Biochemistry, University of California, Irvine, CA, USA., Robillard MS; Tagworks Pharmaceuticals, Nijmegen, Netherlands., Fox JM; Department of Chemistry and Biochemistry, University of Delaware, Newark, DE, USA.

Publikováno v: Nature reviews. Methods primers [Nat Rev Methods Primers] 2021; Vol. 1. Date of Electronic Publication: 2021 Apr 15.