Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Sean R. McMaster"'
Autor:
Pavlo Gilchuk, Timothy M. Hill, Clifford Guy, Sean R. McMaster, Kelli L. Boyd, Whitney A. Rabacal, Pengcheng Lu, Yu Shyr, Jacob E. Kohlmeier, Eric Sebzda, Douglas R. Green, Sebastian Joyce
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1800-1809 (2016)
The nature and anatomic location of the protective memory CD8+ T cell subset induced by intranasal vaccination remain poorly understood. We developed a vaccination model to assess the anatomic location of protective memory CD8+ T cells and their role
Externí odkaz:
https://doaj.org/article/15f906d953aa4a159742ea7280ca2b0a
Autor:
Sean R McMaster, Jon D Gabbard, Dimitris G Koutsonanos, Richard W Compans, Ralph A Tripp, S Mark Tompkins, Jacob E Kohlmeier
Publikováno v:
PLoS ONE, Vol 10, Iss 2, p e0115725 (2015)
Influenza virus is a source of significant health and economic burden from yearly epidemics and sporadic pandemics. Given the potential for the emerging H7N9 influenza virus to cause severe respiratory infections and the lack of exposure to H7 and N9
Externí odkaz:
https://doaj.org/article/2b55b8ced5fc44fc99ba3154422b62c6
Autor:
Paul Dunbar, Jacob E. Kohlmeier, Sean R. McMaster, Alexander N. Wein, Timothy L. Denning, Zheng-Rong Tiger Li
Publikováno v:
The Journal of Immunology. 201:573-582
Although influenza virus infection remains a concerning disease for public health, the roles of individual cytokines during the immune response to influenza infection are not fully understood. We have identified IL-36γ as a key mediator of immune pr
Autor:
Sean R. McMaster, Timothy L. Denning, Alexander N. Wein, Jacob E. Kohlmeier, Sarah L. Hayward, Emily K. Cartwright, Paul Dunbar
Publikováno v:
Mucosal immunology
Resident memory CD8 T (TRM) cells in the lung parenchyma (LP) and airways provide heterologous protection against influenza virus challenge. However, scant knowledge exists regarding factors necessary to establish and maintain lung CD8 TRM. Here we d
Autor:
Toshinori Nakayama, Shiki Takamura, Miki Umemura, Chihiro Motozono, Masaaki Miyazawa, Jun Itoh, Hideki Yagi, Sean R. McMaster, Junko Komeda, Tomoko Masumoto, Ami Kyusai, Yoshiyuki Hakata, Makoto Fujisawa, Michio Tomura, David L. Woodland, Jacob E. Kohlmeier, Tomomi Chikaishi
Publikováno v:
The Journal of Experimental Medicine
Takamura et al. show that most lung CD8+ TRM cells are not maintained in the inducible bronchus-associated lymphoid tissue (iBALT) but are maintained in specific niches created at the site of tissue regeneration, which are termed as repair-associated
Autor:
Sean R. McMaster, Yu Shyr, Eric Sebzda, Pavlo Gilchuk, Sebastian Joyce, Jacob E. Kohlmeier, Kelli L. Boyd, Timothy M. Hill, Whitney Rabacal, Douglas R. Green, Clifford S. Guy, Pengcheng Lu
Publikováno v:
Cell Reports, Vol 16, Iss 7, Pp 1800-1809 (2016)
Summary The nature and anatomic location of the protective memory CD8 + T cell subset induced by intranasal vaccination remain poorly understood. We developed a vaccination model to assess the anatomic location of protective memory CD8 + T cells and
Autor:
Emily K. Cartwright, Shiki Takamura, Daniel T. McManus, Makoto Kurachi, Kouji Matsushima, Takeshi Shimaoka, Paul Dunbar, Sean R. McMaster, Alexander N. Wein, Sarah L. Hayward, Tomoko Masumoto, Tatsuya Tsukui, Satoshi Ueha, Jacob E. Kohlmeier
Publikováno v:
The Journal of Experimental Medicine
Lung TRM cells are present in both the interstitium and airways, but factors regulating their localization to these distinct sites are unknown. This work shows that the CXCR6/CXCL16 axis governs the partitioning of TRM cells to different compartments
Publikováno v:
The FASEB Journal. 32
Autor:
Sean R. McMaster, Timothy L. Denning, Dimitrios G. Koutsonanos, Ioanna Skountzou, Jacob E. Kohlmeier, E. Stein Esser, Jeong Woo Lee, Priya Kalluri, Richard W. Compans, Mark R. Prausnitz
Publikováno v:
Vaccine
Skin has gained substantial attention as a vaccine target organ due to its immunological properties, which include a high density of professional antigen presenting cells (APCs). Previous studies have demonstrated the effectiveness of this vaccinatio
Autor:
Sean R. McMaster, Veronika I. Zarnitsyna, Andreas Handel, Jacob E. Kohlmeier, Rustom Antia, Sarah L. Hayward
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, Vol 7 (2016)
Frontiers in Immunology, Vol 7 (2016)
The current influenza vaccine provides narrow protection against the strains included in the vaccine, and needs to be reformulated every few years in response to the constantly evolving new strains. Novel approaches are directed towards developing va