Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Sean R. Holm"'
Autor:
Nicholas Jones, Emma E. Vincent, James G. Cronin, Silvia Panetti, Megan Chambers, Sean R. Holm, Sian E. Owens, Nigel J. Francis, David K. Finlay, Catherine A. Thornton
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
T-cell subsets differ in metabolic requirements for particular tasks. Here the authors characterize metabolic fluxes in naïve human CD4+ cells upon activation, and identify a role of Stat5 in glutaminolysis linked to IL-2 production.
Externí odkaz:
https://doaj.org/article/bc506b655aa8451493a382dfb1dd1fe8
Autor:
Silvia Panetti, Nicholas Jones, James G. Cronin, Catherine A. Thornton, David K. Finlay, Megan Chambers, Sian E. Owens, Nigel J. Francis, Emma E. Vincent, Sean R Holm
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ' Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Nature Communications
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ', Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ' Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Nature Communications
Jones, N, Vincent, E E, Cronin, J G, Panetti, S, Chambers, M, Holm, S R, Owens, S E, Francis, N J, Finlay, D K & Thornton, C A 2019, ' Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation ', Nature Communications, vol. 10, no. 1, 2042 . https://doi.org/10.1038/s41467-019-10023-4
Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of glycolysis and oxidative phosp
Immune responses of neonates differ markedly to those of adults, with skewed cytokine phenotypes, reduced inflammatory properties and drastically diminished memory function. Recent research efforts have started to unravel the role of cellular metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::312cc1a9887a6c92a36adaaff8b5af65
https://cronfa.swan.ac.uk/Record/cronfa58165/Download/58165__21065__469f05a23fe14199834f33dafa70eb04.pdf
https://cronfa.swan.ac.uk/Record/cronfa58165/Download/58165__21065__469f05a23fe14199834f33dafa70eb04.pdf
The flipped classroom is a relatively new active learning pedagogical intervention, gaining popularity as a blended learning methodology. The flipped classroom comprises two distinct parts, directed learning carried out at the student's own pace away
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c96c31ed0a18f2eb5328381a4be0f61