Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Sean R. Collins"'
Autor:
Suhani B. Bhakta, Stefan M. Lundgren, Bethany N. Sesti, Barbara A. Flores, Emel Akdogan, Sean R. Collins, Frances Mercer
Publikováno v:
PLoS ONE, Vol 19, Iss 2 (2024)
Externí odkaz:
https://doaj.org/article/374d2498da6543b9ace0d2c442207f20
Autor:
Nathan M. Belliveau, Matthew J. Footer, Emel Akdoǧan, Aaron P. van Loon, Sean R. Collins, Julie A. Theriot
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Neutrophils are the most abundant leukocyte in humans and provide a critical early line of defense as part of our innate immune system. We perform a comprehensive, genome-wide assessment of the molecular factors critical to proliferation, di
Externí odkaz:
https://doaj.org/article/33ff884691a34f568a2da6afb085aa21
Autor:
Kacey VanderVorst, Courtney A. Dreyer, Jason Hatakeyama, George R. R. Bell, Julie A. Learn, Anastasia L. Berg, Maria Hernandez, Hyun Lee, Sean R. Collins, Kermit L. Carraway
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-19 (2023)
Abstract Background In light of the growing appreciation for the role of collective cell motility in metastasis, a deeper understanding of the underlying signaling pathways will be critical to translating these observations to the treatment of advanc
Externí odkaz:
https://doaj.org/article/e905f750599d4911b712a3df4fed5973
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Here the authors use optogenetic tools to directly measure spatial signal processing in leukocyte chemotaxis. Their results reveal the importance of multiple negative feedback loops for maintaining spatial information in chemotaxis.
Externí odkaz:
https://doaj.org/article/6ece3c5855d54a95807d677d7e95147c
Autor:
Amalia Hadjitheodorou, George R. R. Bell, Felix Ellett, Shashank Shastry, Daniel Irimia, Sean R. Collins, Julie A. Theriot
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Neutrophils migrate with remarkably stable front-rear polarization. Using optogenetic receptor control to induce reversal of polarization in restrictive microfluidic channels, the authors find that myosin II promotes this stability by suppressing tra
Externí odkaz:
https://doaj.org/article/9b9cbbb7074d45fe8ce70da40ca6262f
Publikováno v:
BMC Genomics, Vol 19, Iss 1, Pp 1-17 (2018)
Abstract Background Human neutrophils are central players in innate immunity, a major component of inflammatory responses, and a leading model for cell motility and chemotaxis. However, primary neutrophils are short-lived, limiting their experimental
Externí odkaz:
https://doaj.org/article/bfa466fd427f43598e856dda6eda5058
Publikováno v:
Cell Reports, Vol 10, Iss 6, Pp 993-1006 (2015)
Functional links between genes can be predicted using phylogenetic profiling, by correlating the appearance and loss of homologs in subsets of species. However, effective genome-wide phylogenetic profiling has been hindered by the large fraction of h
Externí odkaz:
https://doaj.org/article/a099447ca98945f1bc6566f82d4bf700
Autor:
Julie A. Theriot, Shashank Shastry, Daniel Irimia, George R. R. Bell, Sean R. Collins, Amalia Hadjitheodorou, Felix Ellett
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature communications, vol 12, iss 1
Nature Communications
Nature communications, vol 12, iss 1
Nature Communications
To migrate efficiently to target locations, cells must integrate receptor inputs while maintaining polarity: a distinct front that leads and a rear that follows. Here we investigate what is necessary to overwrite pre-existing front-rear polarity in n
Publikováno v:
Methods in Molecular Biology ISBN: 9781071626160
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::655bb495fa5a1f40d6e9aa1c942d06eb
https://doi.org/10.1007/978-1-0716-2617-7_10
https://doi.org/10.1007/978-1-0716-2617-7_10
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2553
Compartmentalized protein recruitment is a fundamental feature of signal transduction. Accordingly, the cell cortex is a primary site of signaling supported by the recruitment of protein regulators to the plasma membrane. Recent emergence of optogene