Zobrazeno 1 - 10
of 61
pro vyhledávání: '"Sean R R, Hall"'
Autor:
Haitang Yang, Yanyun Gao, Duo Xu, Ke Xu, Shun-Qing Liang, Zhang Yang, Amina Scherz, Sean R. R. Hall, Stefan Forster, Sabina Berezowska, Feng Yao, Adrian F. Ochsenbein, Thomas M. Marti, Gregor J. Kocher, Ralph A. Schmid, Patrick Dorn, Ren-Wang Peng
Publikováno v:
Cell Death Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Malignant pleural mesothelioma (MPM) is a lethal malignancy etiologically caused by asbestos exposure, for which there are few effective treatment options. Although asbestos carcinogenesis is associated with reactive oxygen species (ROS), th
Externí odkaz:
https://doaj.org/article/5254c7ce468140869bc77e5e71f90aa3
Autor:
Duo Xu, Shun-Qing Liang, Zhang Yang, Haitang Yang, Rémy Bruggmann, Simone Oberhaensli, Sabina Berezowska, Thomas M. Marti, Sean R. R. Hall, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Publikováno v:
Cell Death and Disease, Vol 12, Iss 4, Pp 1-14 (2021)
Abstract Escape from programmed cell death is a hallmark of cancer. In this study, we investigated the anti-apoptotic mechanisms and explored the therapeutic potential of BCL-2 homology domain-3 (BH3) mimetics in malignant pleural mesothelioma (MPM),
Externí odkaz:
https://doaj.org/article/aa350021d9954b389e7fe2530bd9522a
Autor:
Yanyun Gao, Philipp Zens, Min Su, Camila Anna Gemperli, Haitang Yang, Haibin Deng, Zhang Yang, Duo Xu, Sean R. R. Hall, Sabina Berezowska, Patrick Dorn, Ren-Wang Peng, Ralph Alexander Schmid, Wenxiang Wang, Thomas Michael Marti
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 40, Iss 1, Pp 1-22 (2021)
Abstract Background Pemetrexed (MTA) plus cisplatin combination therapy is considered the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, in advanced NSCLC, the 5-year survival rate is below 10%, mainly due to
Externí odkaz:
https://doaj.org/article/77898471515947d0a1e1ce7aa86c96c0
Autor:
Haitang Yang, MD-PhD, Beibei Sun, Ke Xu, Yunfei He, Tuo Zhang, Sean R R Hall, Swee T. Tan, Ralph A. Schmid, Ren-Wang Peng, Guohong Hu, Feng Yao, MD-PhD
Publikováno v:
EBioMedicine, Vol 69, Iss , Pp 103457- (2021)
Background: Histone acetylation/deacetylase process is one of the most studied epigenetic modifications. Histone deacetylase inhibitors (HDACis) have shown clinical benefits in haematological malignancies but failed in solid tumours due to the lack o
Externí odkaz:
https://doaj.org/article/eeb3790794db40069a031dcc134a184d
Autor:
Melanie Brügger, Thomas Démoulins, G Tuba Barut, Beatrice Zumkehr, Blandina I Oliveira Esteves, Kemal Mehinagic, Quentin Haas, Aline Schögler, Marie-Anne Rameix-Welti, Jean-François Eléouët, Ueli Moehrlen, Thomas M Marti, Ralph A Schmid, Artur Summerfield, Horst Posthaus, Nicolas Ruggli, Sean R R Hall, Marco P Alves
Publikováno v:
PLoS Pathogens, Vol 17, Iss 7, p e1009789 (2021)
Lung-resident (LR) mesenchymal stem and stromal cells (MSCs) are key elements of the alveolar niche and fundamental regulators of homeostasis and regeneration. We interrogated their function during virus-induced lung injury using the highly prevalent
Externí odkaz:
https://doaj.org/article/8c6f6bd720c842c1b4ee5c5c8a900c17
Autor:
Yanyun Gao, Patrick Dorn, Shengchen Liu, Haibin Deng, Sean R. R. Hall, Ren-Wang Peng, Ralph A. Schmid, Thomas M. Marti
Publikováno v:
Cancer Cell International, Vol 19, Iss 1, Pp 1-14 (2019)
Abstract Background Cisplatin plus pemetrexed combination therapy is considered the standard treatment for patients with advanced, non-squamous, non-small-cell lung cancer (NSCLC). However, advanced NSCLC has a 5-year survival rate of below 10%, whic
Externí odkaz:
https://doaj.org/article/771e52eeb8d044dcbefe6075fc730568
Publikováno v:
Frontiers in Surgery, Vol 7 (2021)
Treatment of vascular anomalies (VAs) is mostly empirical and, in many instances unsatisfactory, as the pathogeneses of these heterogeneous conditions remain largely unknown. There is emerging evidence of the presence of cell populations expressing s
Externí odkaz:
https://doaj.org/article/d44b8dc4b8b947e2a13bee716dc09cf5
Publikováno v:
Xu, Ke; Ma, Jie; Hall, Sean R R; Peng, Ren-Wang; Yang, Haitang; Yao, Feng (2023). Battles against aberrant KEAP1-NRF2 signaling in lung cancer: intertwined metabolic and immune networks. Theranostics, 13(2), pp. 704-723. Ivyspring International 10.7150/thno.80184
The Kelch-like ECH-associated protein 1/nuclear factor erythroid-derived 2-like 2 (KEAP1/NRF2) pathway is well recognized as a key regulator of redox homeostasis, protecting cells from oxidative stress and xenobiotics under physiological circumstance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5ed36f9f79e074fff7efb446ae3a5
https://boris.unibe.ch/177349/1/v13p0704.pdf
https://boris.unibe.ch/177349/1/v13p0704.pdf
Publikováno v:
Journal of Thoracic Oncology. 16:e88-e91
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a7d98fe41db8e568b2babbd4f84544c
https://doi.org/10.1016/j.jtho.2021.05.014
https://doi.org/10.1016/j.jtho.2021.05.014
Autor:
Rebecca A M Blom, Silvia T Erni, Kristína Krempaská, Olivier Schaerer, R Maarten van Dijk, Mario Amacker, Christian Moser, Sean R R Hall, Christophe von Garnier, Fabian Blank
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0163539 (2016)
The respiratory tract with its ease of access, vast surface area and dense network of antigen-presenting cells (APCs) represents an ideal target for immune-modulation. Bio-mimetic nanocarriers such as virosomes may provide immunomodulatory properties
Externí odkaz:
https://doaj.org/article/201f49549c164d8d991d74a021eb3741