Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Sean R Marcsisin"'
Autor:
Roland A. Cooper, Susan E. Leed, Qiang Zeng, Kevin A. Reynolds, Lacy Gaynor-Ohnstad, Lisa Xie, Hsiuling Lin, Jason C. Sousa, Jianbing Mu, Heather Gaona, Raul Olmeda, Martin J. Smilkstein, Brett R. Bayles, Brittney Potter, Michael K. Riscoe, Richard J. Sciotti, Papireddy Kancharla, Yuexin Li, Brian Vesely, Sovitj Pou, Sean R. Marcsisin, Chau Vuong, Qigui Li, Brandon S. Pybus, Lisa Read, Victor Melendez, Norma Roncal, Thu Lan Luong, Diana Caridha, Chad C. Black, Rozalia A. Dodean, Jing Zhang, Kirk Butler, Patrick K Tumwebaze, Charles E. Bane, Philip J. Rosenthal, Stephanie A Rasmussen, Mara Kreishman-Deitrick, Jane Xu Kelly, Frida G. Ceja, Ping Zhang, Christina K. Nolan
Publikováno v:
J Med Chem
The global impact of malaria remains staggering despite extensive efforts to eradicate the disease. With increasing drug resistance and the absence of a clinically available vaccine, there is an urgent need for novel, affordable, and safe drugs for p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03a8e0165bf6ef34369b69238cb312a6
https://doi.org/10.1021/acs.jmedchem.0c00539
https://doi.org/10.1021/acs.jmedchem.0c00539
Autor:
William F. McCarthy, Donna Tosh, Kristopher M Paolino, Meshell N Morrison, James E Moon, Sean R Marcsisin, Jason W. Bennett, Christian A Darko, Qigui Li, Patrick Twomey, Philip L Smith, Brittney M Potter, Gregory A Reichard, Susan B Cicatelli, Brandon S Pybus, Kristin T Mills, Jeffrey W Froude, Thomas G Oliver, Michele D. Spring, Norman C. Waters, Jason C Sousa
Publikováno v:
The Journal of Infectious Diseases
BackgroundPlasmodium vivax malaria requires a 2-week course of primaquine (PQ) for radical cure. Evidence suggests that the hepatic isoenzyme cytochrome P450 2D6 (CYP2D6) is the key enzyme required to convert PQ into its active metabolite.MethodsCYP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab00d588e72cbdb11445682b8480461c
https://doi.org/10.1093/infdis/jiz386
https://doi.org/10.1093/infdis/jiz386
Autor:
Sean R. Marcsisin, Nicole L. T. Moore, Rachel M. Taylor, Jason C. Sousa, Laurence Simmons, Chau T. Vuong, Victor E. Zottig, Daniel E. Altman
Publikováno v:
Stress. 21:267-273
Adolescence is a distinct developmental period characterized by behavioral and physiological maturation. Rapid ongoing changes during neurodevelopment in particular present potential opportunities for stress to have lasting effects on longitudinal ou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960c4cb3ed4f899b5cabf925810cb554
https://doi.org/10.1080/10253890.2018.1439012
https://doi.org/10.1080/10253890.2018.1439012
Autor:
Kevin Gillespie, Nicole Andenmatten, Youyi Fong, Stefan H. I. Kappe, Holly Janes, Ryan L. Jensen, Nicola Kerr, Annette M. Seilie, Sean R. Marcsisin, Jörg J. Möhrle, Amelia E. Hanron, Tracie VonGoedert, Sue Ferguson, Kelly J. Shipman, Elizabeth R. Duke, James G. Kublin, Stephan Duparc, Laurie Rinn, Thomas Rueckle, Emma Fritzen, Matthew Fishbaugher, Ming Chang, Stephan Chalon, Jason C. Sousa, Sean C. Murphy
Publikováno v:
The Journal of Infectious Diseases. 217:693-702
Background DSM265 is a selective inhibitor of Plasmodium dihydroorotate dehydrogenase that fully protected against controlled human malarial infection (CHMI) by direct venous inoculation of Plasmodium falciparum sporozoites when administered 1 day be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6918a2614f5f9f725784af4dc94b7f47
https://doi.org/10.1093/infdis/jix613
https://doi.org/10.1093/infdis/jix613
Autor:
Jason C. Sousa, Sean R. Marcsisin, Brandon S. Pybus, Kimberly Sparks, Dustin K. Davis, David A. Bookstaver
Publikováno v:
Annals of Pharmacotherapy. 52:251-256
Background: There is no established method for monitoring the anticoagulant effects of apixaban and rivaroxaban. Linear correlation between serum levels and anti-Xa activity has been shown, with r2 ranging from 0.88 to 0.99. However, there are minima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a24bbd47aa35f6406fe202c002e3bbad
https://doi.org/10.1177/1060028017738262
https://doi.org/10.1177/1060028017738262
Autor:
Frank C. Tortella, Casandra M. Cartagena, Chau Vuong, Andrea Mountney, Xi-Chu Lu, Janice S. Gilsdorf, Angela M. Yarnell, Chanyang Rho, Sean R. Marcsisin, Angela M. Boutté, Victor E. Zottig, Jason C. Sousa, Ying Deng-Bryant, Wyane D Johnson, Deborah A. Shear, Lai Yee Leung, William F Flerlage
Publikováno v:
Journal of Neurotrauma. 34:2768-2789
Closed-head concussive injury is one of the most common causes of traumatic brain injury (TBI). Isolated concussions frequently produce acute neurological impairments, and individuals typically recover spontaneously within a short time frame. In cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79353769ace5f8de7ec7ba7527555ce8
https://doi.org/10.1089/neu.2016.4679
https://doi.org/10.1089/neu.2016.4679
Autor:
Sean R. Marcsisin, Norma Roncal, Lisa Read, Qigui Li, Lisa Xie, Qiang Zeng, Jason C. Sousa, Mark Hickman, Chau Vuong, Jing Zhang, Diana Caridha, Brittney Potter, Ping Zhang
Publikováno v:
Malaria Research and Treatment, Vol 2017 (2017)
Malaria Research and Treatment
Malaria Research and Treatment
Decoquinate nanoparticle and microparticle suspended in an oily vehicle to retard drug release are evaluated for long-term malaria prophylaxis. Pharmacokinetic studies in normal animals and antimalarial efficacy in liver stage malaria mice were condu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::792458650129052c90e97ed898e62055
https://doi.org/10.1155/2017/7508291
https://doi.org/10.1155/2017/7508291
Autor:
Steve Kuntz, Patrick E. Duffy, Sara A. Healy, Anna Wald, Stefan H. I. Kappe, Jen C. C. Hume, Ruobing Wang, Sean R. Marcsisin, Angela K Talley, Mark Kennedy, Richa Chaturvedi, Olivia C Finney, Kenneth Stuart, Sean C. Murphy, Barbara Metch, Lisa Shelton, Sharon Wong-Madden, Margaret Warner-Lubin, Matthew Fishbaugher, Wesley C. Van Voorhis, Charlotte V. Hobbs, James G. Kublin, Zoe Moodie, Tiffany Silver-Brace
Publikováno v:
Clin Infect Dis
Background Chemoprophylaxis vaccination with sporozoites (CVac) with chloroquine induces protection against a homologous Plasmodium falciparum sporozoite (PfSPZ) challenge, but whether blood-stage parasite exposure is required for protection remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a0b777700a95bcc18d065e597166460
https://pubmed.ncbi.nlm.nih.gov/31621832
https://pubmed.ncbi.nlm.nih.gov/31621832
Autor:
Yuexin Li, Kirk Butler, Brittney Potter, Qigui Li, Papireddy Kancharla, Roland A. Cooper, Thu Lan Luong, Heather Gaona, Jing Zhang, Richard J. Sciotti, Brian Vesely, Chau Vuong, Qiang Zeng, Sean R. Marcsisin, Michael K. Riscoe, Diana Caridha, Jason C. Sousa, Rolf W. Winter, Norma Roncal, Christina K. Nolan, Lisa Read, Rozalia A. Dodean, Lisa Xie, Lacy Gaynor-Ohnstad, Stephanie J. Huezo, Susan E. Leed, Hsiuling Lin, John C. Tan, Martin J. Smilkstein, Stephanie A Rasmussen, Jane Xu Kelly, Ping Zhang, Chad C. Black, Melissa T. Stephens, Mara Kreishman-Deitrick, Raul Olmeda, Victor Melendez, Sovitj Pou, Charles E. Bane
Malaria remains one of the deadliest diseases in the world today. Novel chemoprophylactic and chemotherapeutic antimalarials are needed to support the renewed eradication agenda. We have discovered a novel antimalarial acridone chemotype with dual-st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351c0f6f16032d54883ac7a5e8be555b
https://europepmc.org/articles/PMC6822569/
https://europepmc.org/articles/PMC6822569/
