Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Sean Porazinski"'
Autor:
Marina Pajic, Vishal Kothari, Diego Chacon Fajardo, Chad L Moore, Sean Porazinski, Benjamin McLean, Eve Borbilas, Tim Machajewski, Fernando Rock, Scott M Turner
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/dbc9ee3f6eb145d99efcd87f82a50b5b
Autor:
Laveniya Satgunaseelan, Sean Porazinski, Dario Strbenac, Aji Istadi, Cali Willet, Tracy Chew, Rosemarie Sadsad, Carsten E. Palme, Jenny H. Lee, Michael Boyer, Jean Y. H. Yang, Jonathan R. Clark, Marina Pajic, Ruta Gupta
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
There is an increasing worldwide incidence of patients under 50 years of age presenting with oral squamous cell carcinoma (OSCC). The molecular mechanisms driving disease in this emerging cohort remain unclear, limiting impactful treatment options fo
Externí odkaz:
https://doaj.org/article/693a649c31a8476a9a20a57ba960f116
Autor:
Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson, Michael Ladomery
Publikováno v:
BMC Cancer, Vol 18, Iss 1, Pp 1-11 (2018)
Abstract Background Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of cancer associated genes
Externí odkaz:
https://doaj.org/article/4b2aec01eda443a9b6a2b5af981e61b1
Alternative Splicing in the Hippo Pathway—Implications for Disease and Potential Therapeutic Targets
Autor:
Sean Porazinski, Michael Ladomery
Publikováno v:
Genes, Vol 9, Iss 3, p 161 (2018)
Alternative splicing is a well-studied gene regulatory mechanism that produces biological diversity by allowing the production of multiple protein isoforms from a single gene. An involvement of alternative splicing in the key biological signalling Hi
Externí odkaz:
https://doaj.org/article/c75de1b1b17c4d2fa4fdc22869762929
Publikováno v:
Regular and Young Investigator Award Abstracts.
Autor:
Sean Porazinski, Joanne Lundy, Daniel Croagh, Liang Yu, Hugh Gao, Virginie Deswaerte, Louise McLeod, Paul J. Hertzog, Linden J. Gearing, Alison C. West, Brendan J. Jenkins, Marina Pajic
Publikováno v:
Oncogene. 40:6007-6022
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options and tumour resistance to chemotherapeutics. The causal link between chronic inflammation and PDAC suggests that molecul
Autor:
Scott Lovell, Viktor Magdolen, John D. Hooper, Julia Yin, Hannu Koistinen, Thomas Kryza, Ute Reuning, Tobias Dreyer, Marina Pajic, Tashbib Khan, Juha Rantala, Sean Porazinski, Brittney S. Harrington, Edward W. Tate, Yaowu He
CDCP1 is an oncogenic orphan transmembrane receptor and a promising target for detection and treatment of cancer. Extracellular proteolysis of CDCP1 by poorly defined mechanisms induces pro-metastatic signaling. We describe a novel approach for rapid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d21cb45481c458d8a105062a7e0c95c
https://doi.org/10.21203/rs.3.rs-92391/v1
https://doi.org/10.21203/rs.3.rs-92391/v1
Autor:
Thomas Kryza, Ute Reuning, Tobias Dreyer, Marina Pajic, Viktor Magdolen, Yaowu He, Julia Yin, Juha Rantala, Edward W. Tate, Hannu Koistinen, Scott Lovell, Brittney S. Harrington, Tashbib Khan, John D. Hooper, Sean Porazinski
Publikováno v:
Nature chemical biology. 17(7)
CUB domain-containing protein 1 (CDCP1) is an oncogenic orphan transmembrane receptor and a promising target for the detection and treatment of cancer. Extracellular proteolysis of CDCP1 by poorly defined mechanisms induces pro-metastatic signaling.
Autor:
Joanne, Lundy, Linden J, Gearing, Hugh, Gao, Alison C, West, Louise, McLeod, Virginie, Deswaerte, Liang, Yu, Sean, Porazinski, Marina, Pajic, Paul J, Hertzog, Daniel, Croagh, Brendan J, Jenkins
Publikováno v:
Oncogene. 40(41)
Pancreatic ductal adenocarcinoma (PDAC) has an extremely poor prognosis, and is plagued by a paucity of targeted treatment options and tumour resistance to chemotherapeutics. The causal link between chronic inflammation and PDAC suggests that molecul
Autor:
Padilha A, Zaragkoulias A, William Hill, Owen J. Sansom, Sean Porazinski, Jennifer P. Morton, Geraint J. Parfitt, Salvador B, Markella Alatsatianos, Catherine Hogan, Thomas E. Woolley
SummaryAs we age, our tissues are repeatedly challenged by mutational insult, yet cancer occurrence is a relatively rare event. Cells carrying cancer-causing genetic mutations compete with normal neighbours for space and survival in tissues. However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::498fcadf236fbd0365e2232270057f5a
https://doi.org/10.1101/2020.08.04.231050
https://doi.org/10.1101/2020.08.04.231050