Výsledky vyhledávání - "Sean P. McBurney"

Akademický článek

Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA.

Autor: Shelly J Krebs, Sean P McBurney, Dina N Kovarik, Chelsea D Waddell, J Pablo Jaworski, William F Sutton, Michelle M Gomes, Maria Trovato, Garret Waagmeester, Susan J Barnett, Piergiuseppe DeBerardinis, Nancy L Haigwood

Publikováno v: PLoS ONE, Vol 9, Iss 12, p e113463 (2014)

Developing a vaccine that overcomes the diversity of HIV-1 is likely to require a strategy that directs antibody (Ab) responses toward conserved regions of the viral Envelope (Env). However, the generation of neutralizing Abs (NAbs) targeting these r

Externí odkaz: https://doaj.org/article/02b9ad27a3cc4e9989f81cdbf0ecf0ed

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Induction of neutralizing antibodies in rhesus macaques using V3 mimotope peptides

Autor: Susan Zolla-Pazner, Miroslaw K. Gorny, Shilpi Pandey, Liuzhe Li, William F. Sutton, Sean P. McBurney, Nancy L. Haigwood, Lily Liu, Ann J. Hessell, Maxim Totrov

Publikováno v: Vaccine. 34:2713-2721

RV144 vaccinees with low HIV-1 Envelope-specific IgA antibodies (Abs) also had Abs directed to the hypervariable region 3 (V3) that inversely correlated with infection risk. Thus, anti-V3 HIV-1 Abs may contribute to protection from HIV-1 infection. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90009328b596d22478cf4bb385643e75
https://doi.org/10.1016/j.vaccine.2016.04.027

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Reduced Cell-Associated DNA and Improved Viral Control in Macaques following Passive Transfer of a Single Anti-V2 Monoclonal Antibody and Repeated Simian/Human Immunodeficiency Virus Challenges

Autor: Tracy Cheever, Delphine C. Malherbe, Sean P. McBurney, Byung Park, Christoph Kahl, Shilpi Pandey, Rebecca L.R. Powell, Nancy L. Haigwood, William F. Sutton, Susan Zolla-Pazner, Mariya B. Shapiro, Ann J. Hessell

Publikováno v: Journal of virology. 92(11)

A high level of V1V2-specific IgG antibodies (Abs) in vaccinees' sera was the only independent variable that correlated with a reduced risk of human immunodeficiency virus (HIV) acquisition in the RV144 clinical trial. In contrast, IgG avidity, antib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49db864ff0467f7fdf3ef3cd477dc6c3
https://pubmed.ncbi.nlm.nih.gov/29514914

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C1q binding to dengue virus decreases levels of infection and inflammatory molecules transcription in THP-1 cells

Autor: Amanda Pfaff Smith, Jared D. Evans, Ernesto T. A. Marques, Neel K. Krishna, Sean P. McBurney, Eduardo J. M. Nascimento, Bruno Douradinha, Simon M. Barratt-Boyes, Klecia M. Soares de Melo

Publikováno v: Virus Research. 179:231-234

Dengue virus infection elicits a spectrum of clinical presentations ranging from asymptomatic to severe disease. The mechanisms leading to severe dengue are not known, however it has been reported that the complement system is hyper-activated in seve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f9c35057e648fe72e5de0d1611a15c
https://doi.org/10.1016/j.virusres.2013.11.007

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Association between Magnitude of the Virus-Specific Plasmablast Response and Disease Severity in Dengue Patients

Autor: Jared D. Evans, Tatiana M. Garcia-Bates, Simon M. Barratt-Boyes, Klecia M. Soares de Melo, Eduardo J. M. Nascimento, Sean P. McBurney, Ernesto T. A. Marques, Marli Tenório Cordeiro, Amanda Pfaff Smith

Publikováno v: The Journal of Immunology. 190:80-87

Dengue is a globally expanding disease caused by infection with dengue virus (DENV) that ranges from febrile illness to acute disease with serious complications. Secondary infection predisposes individuals to more severe disease, and B lymphocytes ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c27f75805f8e00575d179f7054b1bfd
https://doi.org/10.4049/jimmunol.1103350

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E2 multimeric scaffold for vaccine formulation: immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells

Autor: Nancy L. Haigwood, Sean P. McBurney, Rossella Sartorius, Fausta Cuccaro, Valerio Costa, Antonella Prisco, Mauro Rossi, Piergiuseppe De Berardinis, Maria Trovato, Luciana D'Apice, Shelly J. Krebs, Francesco Maurano, Alfredo Ciccodicola

Publikováno v: BMC Microbiology (Online) (2016). doi:10.1186/s12866-016-0772-x
info:cnr-pdr/source/autori:Trovato M, Maurano F, D'Apice L, Costa V, Sartorius R, Cuccaro F, McBurney SP, Krebs SJ, Prisco A, Ciccodicola A, Rossi M, Haigwood NL, De Berardinis P./titolo:E2 multimeric scaffold for vaccine formulation: immune response by intranasal delivery and transcriptome profile of E2-pulsed dendritic cells./doi:10.1186%2Fs12866-016-0772-x/rivista:BMC Microbiology (Online)/anno:2016/pagina_da:/pagina_a:/intervallo_pagine:/volume
BMC Microbiology

BACKGROUND: The E2 multimeric scaffold represents a powerful delivery system able to elicit robust humoral and cellular immune responses upon systemic administrations. Here recombinant E2 scaffold displaying the third variable loop of HIV-1 Envelope

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8358884a2a8f3624e986ce52adf35931
https://publications.cnr.it/doc/363950

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Evaluation of Heterologous Vaginal SHIV SF162p4 Infection Following Vaccination with a Polyvalent Clade B Virus-Like Particle Vaccine

Autor: Ted M. Ross, Donald N. Forthal, Gary Landucci, Sean P. McBurney

Publikováno v: McBurney, Sean P.; Landucci, Gary; Forthal, Donald N.; & Ross, Ted M.(2012). Evaluation of Heterologous Vaginal SHIV SF162p4 Infection Following Vaccination with a Polyvalent Clade B Virus-Like Particle Vaccine. AIDS Research and Human Retroviruses, 28(9), 863-872. UC Irvine: Institute for Clinical and Translational Science. Retrieved from: http://www.escholarship.org/uc/item/2014j63g

The vast diversity of HIV-1 infections has greatly impeded the development of a successful HIV-1/AIDS vaccine. Previous vaccine work has demonstrated limited levels of protection against SHIV/SIV infection, but protection was observed only when the c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e735e6748cc8a1abd558d36dc5a2604a
https://doi.org/10.1089/aid.2011.0351

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Viral sequence diversity: challenges for AIDS vaccine designs

Autor: Ted M. Ross, Sean P. McBurney

Publikováno v: Expert Review of Vaccines. 7:1405-1417

Among the greatest challenges facing AIDS vaccine development is the intrinsic diversity among circulating populations of HIV-1 in various geographical locations and the need to develop vaccines that can elicit enduring protective immunity to variant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34446e2c142b2caf4b4a75bf48c43bde
https://doi.org/10.1586/14760584.7.9.1405

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Membrane embedded HIV-1 envelope on the surface of a virus-like particle elicits broader immune responses than soluble envelopes

Autor: Ted M. Ross, Sean P. McBurney, Kelly R. Young

Publikováno v: Virology. 358:334-346

Virally regulated HIV-1 particles were expressed from DNA plasmids encoding Gag, protease, reverse transcriptase, Vpu, Tat, Rev, and Env. The sequences for integrase, Vpr, Vif, Nef, and the long terminal repeats (LTRs) were deleted. Mutations were en

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::891ccbca19906679bf9c0f26a443f8eb
https://doi.org/10.1016/j.virol.2006.08.032

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Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens

Autor: Nancy L. Haigwood, Celia C. LaBranche, Matthew D. Gray, Deborah H. Fuller, Delphine C. Malherbe, Ann J. Hessell, Michelle M. Gomes, Harlan Robins, Franco Pissani, Byung Park, Leonidas Stamatatos, Shelly J. Krebs, Shilpi Pandey, Jonah B. Sacha, D. Noah Sather, William F. Sutton, Benjamin J. Burwitz, David C. Montefiori, Sean P. McBurney

Publikováno v: Journal of immunology (Baltimore, Md. : 1950). 196(7)

Advancement in immunogen selection and vaccine design that will rapidly elicit a protective Ab response is considered critical for HIV vaccine protective efficacy. Vaccine-elicited Ab responses must therefore have the capacity to prevent infection by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9330c33f6f062bdbfbb307b8ad679c8f
https://pubmed.ncbi.nlm.nih.gov/26944928

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