Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Sean P. Didion"'
Autor:
Raffaele Altara, Romain Harmancey, Sean P Didion, George W. Booz, Fouad Zouein, Fouad A Zouein
Publikováno v:
Frontiers in Pharmacology, Vol 7 (2016)
Signal transducer and activator of transcription 3 (STAT3) protects the heart from acute ischemic stress. However, the importance of STAT3 to the heart in chronic stress, such as hypertension, is not known. To study this, we used cardiomyocyte-target
Externí odkaz:
https://doaj.org/article/384020fe5470480690b7031af0c447d0
Autor:
Sean P Didion, Jessica R Gomolak
Publikováno v:
Frontiers in Physiology, Vol 5 (2014)
Angiotensin II (Ang II) is associated with vascular hypertrophy, endothelial dysfunction and activation of a number of inflammatory molecules, however the linear events involved in the development of hypertension and endothelial dysfunction produced
Externí odkaz:
https://doaj.org/article/05486ac9e4b04d5f81ee4263481051b0
Autor:
Fan Fan, Cheng-Wen Sun, Kristopher G Maier, Jan M Williams, Malikarjuna R Pabbidi, Sean P Didion, John R Falck, Jialong Zhuo, Richard J Roman
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82482 (2013)
The present study examined whether 20-hydroxyeicosatetraenoic acid (HETE) contributes to the vasoconstrictor effect of angiotensin II (ANG II) in renal microvessels by preventing activation of the large conductance Ca(2+)-activated K(+) channel (KCa)
Externí odkaz:
https://doaj.org/article/6632f31c961c4c898659b73d9389f703
The Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway is a key signaling pathway for a diverse array of stimuli, including a number of growth factors and cytokines. The JAK family of kinases include JAK1, JAK2, JAK3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8b21dd06eed3f5ad192b73bb2555730e
https://doi.org/10.1201/9781351042468-7
https://doi.org/10.1201/9781351042468-7
Autor:
Jian-Xiong Chen, Xiaochen He, Sean P. Didion, Sean T. Chen, Richard J. Roman, Judy L. Aschner, Heng Zeng
Publikováno v:
Journal of Molecular and Cellular Cardiology. 112:104-113
Endothelial glycolysis plays a critical role in the regulation of angiogenesis. We investigated the role of Sirtuin 3 (SIRT3) on endothelial cell (EC) glycolytic metabolism, angiogenesis, and diastolic function. Our aim was to test the hypothesis tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8524003f803a80abf67a3c3acbcde73
https://doi.org/10.1016/j.yjmcc.2017.09.007
https://doi.org/10.1016/j.yjmcc.2017.09.007
Autor:
Sean P. Didion
Publikováno v:
Medical Hypotheses. 106:6-9
Nephron endowment, the total number of nephrons an individual is born with, is determined by both genetic and environmental factors during embryonic development. In 1988, Brenner hypothesized that there was an inverse relationship between nephron num
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b68d1abb0a6e5bb41e2f8b4c13e73a06
https://doi.org/10.1016/j.mehy.2017.06.020
https://doi.org/10.1016/j.mehy.2017.06.020
Autor:
Sean P. Didion
Publikováno v:
Journal of neurology & neuromedicine
Nitric oxide derived from endothelial nitric oxide synthase (eNOS) has been shown to be a major mediator of endothelium-dependent responses in cerebral blood vessels. Loss of a single eNOS gene is not associated with any apparent negative consequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f780ca35e2d9d58119b9475732acf6
http://europepmc.org/articles/PMC5467886
http://europepmc.org/articles/PMC5467886
Autor:
Michael R. Garrett, Erin B. Taylor, Michael J. Ryan, Hannah R. Turbeville, Sean P. Didion, Jennifer M. Sasser
Publikováno v:
Hypertension (Dallas, Tex. : 1979). 73(3)
Preeclampsia results in increased susceptibility to hypertension and chronic kidney disease postpartum; however, the mechanisms responsible for disease progression in these women remain unknown. The purpose of this study was to test the hypothesis th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e4d0aaadc35c0c91caf4c5674795a9
https://pubmed.ncbi.nlm.nih.gov/30612494
https://pubmed.ncbi.nlm.nih.gov/30612494
Autor:
Jan M. Williams, Ashley C. Johnson, Sean P. Didion, Aron M. Geurts, Michael R. Garrett, Lateia Taylor, Kasi C McPherson
Publikováno v:
American Journal of Physiology-Renal Physiology. 311:F793-F804
The current study examined the effect of obesity on the development of renal injury within the genetic background of the Dahl salt-sensitive rat with a dysfunctional leptin receptor derived from zinc-finger nucleases (SSLepRmutant strain). At 6 wk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5851cde9a187d6a56be9ca11b45fe18
https://doi.org/10.1152/ajprenal.00590.2015
https://doi.org/10.1152/ajprenal.00590.2015
Autor:
Sean P. Didion
Publikováno v:
Hypertension. 70:700-702
See related article, pp 839–845 Expression and activation of inflammatory genes and pathways have been linked to several cardiovascular diseases, such as atherosclerosis, diabetes mellitus, and high blood pressure. For example, genetic deficiency o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c28840e2fc5847fcb88652a1e9ab684b
https://doi.org/10.1161/hypertensionaha.117.09485
https://doi.org/10.1161/hypertensionaha.117.09485