Personalized medicine in a community health system: the NorthShore experience

Autor: Sean P. David, Henry M. Dunnenberger, Sarah Choi, Allison DePersia, Nadim Ilbawi, Christopher Ward, Dyson T. Wake, Janardan D. Khandekar, Yvette Shannon, Kristen Hughes, Nicholas Miller, Kathy A. Mangold, Linda M. Sabatini, Donald L. Helseth, Jianfeng Xu, Alan Sanders, Karen L. Kaul, Peter J. Hulick

Publikováno v: Frontiers in Genetics, Vol 14 (2023)

Genomic and personalized medicine implementation efforts have largely centered on specialty care in tertiary health systems. There are few examples of fully integrated care systems that span the healthcare continuum. In 2014, NorthShore University He

Externí odkaz: https://doaj.org/article/8d8d123c992c44b8bc21a5215773cee4

Gene by Environment Investigation of Incident Lung Cancer Risk in African-Americans

Autor: Sean P. David, Ange Wang, Kristopher Kapphahn, Haley Hedlin, Manisha Desai, Michael Henderson, Lingyao Yang, Kyle M. Walsh, Ann G. Schwartz, John K. Wiencke, Margaret R. Spitz, Angela S. Wenzlaff, Margaret R. Wrensch, Charles B. Eaton, Helena Furberg, W. Mark Brown, Benjamin A. Goldstein, Themistocles Assimes, Hua Tang, Charles L. Kooperberg, Charles P. Quesenberry, Hilary Tindle, Manali I. Patel, Christopher I. Amos, Andrew W. Bergen, Gary E. Swan, Marcia L. Stefanick

Publikováno v: EBioMedicine, Vol 4, Iss C, Pp 153-161 (2016)

Background: Genome-wide association studies have identified polymorphisms linked to both smoking exposure and risk of lung cancer. The degree to which lung cancer risk is driven by increased smoking, genetics, or gene–environment interactions is no

Externí odkaz: https://doaj.org/article/5926cde414c74bf4bb28460f6ac2ea38

Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.

Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing

Autor: Fang Chen, Xingyan Wang, Seon-Kyeong Jang, Bryan C. Quach, J. Dylan Weissenkampen, Chachrit Khunsriraksakul, Lina Yang, Renan Sauteraud, Christine M. Albert, Nicholette D. D. Allred, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, R. Graham Barr, Diane M. Becker, Lawrence F. Bielak, Joshua C. Bis, John Blangero, Meher Preethi Boorgula, Daniel I. Chasman, Sameer Chavan, Yii-Der I. Chen, Lee-Ming Chuang, Adolfo Correa, Joanne E. Curran, Sean P. David, Lisa de las Fuentes, Ranjan Deka, Ravindranath Duggirala, Jessica D. Faul, Melanie E. Garrett, Sina A. Gharib, Xiuqing Guo, Michael E. Hall, Nicola L. Hawley, Jiang He, Brian D. Hobbs, John E. Hokanson, Chao A. Hsiung, Shih-Jen Hwang, Thomas M. Hyde, Marguerite R. Irvin, Andrew E. Jaffe, Eric O. Johnson, Robert Kaplan, Sharon L. R. Kardia, Joel D. Kaufman, Tanika N. Kelly, Joel E. Kleinman, Charles Kooperberg, I-Te Lee, Daniel Levy, Sharon M. Lutz, Ani W. Manichaikul, Lisa W. Martin, Olivia Marx, Stephen T. McGarvey, Ryan L. Minster, Matthew Moll, Karine A. Moussa, Take Naseri, Kari E. North, Elizabeth C. Oelsner, Juan M. Peralta, Patricia A. Peyser, Bruce M. Psaty, Nicholas Rafaels, Laura M. Raffield, Muagututi’a Sefuiva Reupena, Stephen S. Rich, Jerome I. Rotter, David A. Schwartz, Aladdin H. Shadyab, Wayne H-H. Sheu, Mario Sims, Jennifer A. Smith, Xiao Sun, Kent D. Taylor, Marilyn J. Telen, Harold Watson, Daniel E. Weeks, David R. Weir, Lisa R. Yanek, Kendra A. Young, Kristin L. Young, Wei Zhao, Dana B. Hancock, Bibo Jiang, Scott Vrieze, Dajiang J. Liu

Publikováno v: Nature genetics, vol 55, iss 2

Most transcriptome-wide association studies (TWASs) so far focus on European ancestry and lack diversity. To overcome this limitation, we aggregated genome-wide association study (GWAS) summary statistics, whole-genome sequences and expression quanti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d510c0fa2bfa1f57584eb6b25fe86e83
https://doi.org/10.1038/s41588-022-01282-x

Rare genetic variants explain missing heritability in smoking

Autor: Seon-Kyeong Jang, Luke Evans, Allison Fialkowski, Donna K. Arnett, Allison E. Ashley-Koch, Kathleen C. Barnes, Diane M. Becker, Joshua C. Bis, John Blangero, Eugene R. Bleecker, Meher Preethi Boorgula, Donald W. Bowden, Jennifer A. Brody, Brian E. Cade, Brenda W. Campbell Jenkins, April P. Carson, Sameer Chavan, L. Adrienne Cupples, Brian Custer, Scott M. Damrauer, Sean P. David, Mariza de Andrade, Carla L. Dinardo, Tasha E. Fingerlin, Myriam Fornage, Barry I. Freedman, Melanie E. Garrett, Sina A. Gharib, David C. Glahn, Jeffrey Haessler, Susan R. Heckbert, John E. Hokanson, Lifang Hou, Shih-Jen Hwang, Matthew C. Hyman, Renae Judy, Anne E. Justice, Robert C. Kaplan, Sharon L. R. Kardia, Shannon Kelly, Wonji Kim, Charles Kooperberg, Daniel Levy, Donald M. Lloyd-Jones, Ruth J. F. Loos, Ani W. Manichaikul, Mark T. Gladwin, Lisa Warsinger Martin, Mehdi Nouraie, Olle Melander, Deborah A. Meyers, Courtney G. Montgomery, Kari E. North, Elizabeth C. Oelsner, Nicholette D. Palmer, Marinelle Payton, Anna L. Peljto, Patricia A. Peyser, Michael Preuss, Bruce M. Psaty, Dandi Qiao, Daniel J. Rader, Nicholas Rafaels, Susan Redline, Robert M. Reed, Alexander P. Reiner, Stephen S. Rich, Jerome I. Rotter, David A. Schwartz, Aladdin H. Shadyab, Edwin K. Silverman, Nicholas L. Smith, J. Gustav Smith, Albert V. Smith, Jennifer A. Smith, Weihong Tang, Kent D. Taylor, Marilyn J. Telen, Ramachandran S. Vasan, Victor R. Gordeuk, Zhe Wang, Kerri L. Wiggins, Lisa R. Yanek, Ivana V. Yang, Kendra A. Young, Kristin L. Young, Yingze Zhang, Dajiang J. Liu, Matthew C. Keller, Scott Vrieze

Publikováno v: Nature human behaviour, vol 6, iss 11
Nat Hum Behav

Common genetic variants explain less variation in complex phenotypes than inferred from family-based studies, and there is a debate on the source of this 'missing heritability'. We investigated the contribution of rare genetic variants to tobacco use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30aa88d7690dcca16453c7af4c2f580f
https://escholarship.org/uc/item/3v26257d