Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Sean P. Brown"'
Autor:
Matthew Bratkowski, Tian Xie, Desiree A. Thayer, Shradha Lad, Prakhyat Mathur, Yu-San Yang, Gregory Danko, Thomas C. Burdett, Jean Danao, Aaron Cantor, Jennifer A. Kozak, Sean P. Brown, Xiaochen Bai, Shilpa Sambashivan
Publikováno v:
Cell Reports, Vol 32, Iss 5, Pp 107999- (2020)
Summary: The NADase SARM1 is a central switch in injury-activated axon degeneration, an early hallmark of many neurological diseases. Here, we present cryo-electron microscopy (cryo-EM) structures of autoinhibited (3.3 Å) and active SARM1 (6.8 Å) a
Externí odkaz:
https://doaj.org/article/313bc7f0c8174c0b846a7e9facf8f63c
Publikováno v:
Life, Vol 13, Iss 12, p 2281 (2023)
Would another origin of life resemble Earth’s biochemical use of amino acids? Here, we review current knowledge at three levels: (1) Could other classes of chemical structure serve as building blocks for biopolymer structure and catalysis? Amino ac
Externí odkaz:
https://doaj.org/article/129bcb766a8c4140af98d5bbae73a6cf
Publikováno v:
Catalysis Communications, Vol 167, Iss , Pp 106438- (2022)
For the first time ammonia-synthesis-on-nitridation has been reported in CoMo during a chemical looping ammonia synthesis experiment. The observation lends evidence to the existence of a dynamic surface, a shrinking core and counter diffusion. The Ma
Externí odkaz:
https://doaj.org/article/e012c0a6fef84ba9ba519ac5c49ef73f
Autor:
Priyanka Prajapati, Shruti Kane, Rachel C. McBrinn, Morven S. Dean, Sarah J. Martins da Silva, Sean G. Brown
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 19, p 11253 (2022)
Progesterone and prostaglandin E1 are postulated to trigger the human sperm acrosome reaction (AR). However, their reported efficacy is very variable which likely, in part, reflects the plethora of experimental conditions and methodologies used to de
Externí odkaz:
https://doaj.org/article/adb11d38db204944a3fe732a81b12d7d
Autor:
Michelle J. Moyer, Evangeline M. Rose, D'Juan A. Moreland, Aiman Raza, Sean M. Brown, Alexis L. Scarselletta, Bernard Lohr, Karan J. Odom, Kevin E. Omland
Publikováno v:
Journal of Field Ornithology, Vol 93, Iss 1, p 3 (2022)
Female birds in many temperate species are thought to sing reduced or quieter songs and appear to sing less often than their male counterparts. Therefore, female song may be easily overlooked. Increasingly, researchers are recording female song in we
Externí odkaz:
https://doaj.org/article/c52e5e8db19143e58ea977158b75ded7
Autor:
Aaron N. Hata, Paul E. Hughes, Cyril H. Benes, Angela Coxon, Sean P. Brown, Kristopher A. Sarosiek, Justin F. Gainor, Christopher G. Azzoli, Anna F. Farago, Zofia Piotrowska, Lecia V. Sequist, Colleen Keyes, John H. Shin, Daniel P. Cahill, Kevin A. Raskin, Cameron D. Wright, Michael Lanuti, Lorin A. Ferris, Kristof Vajda, Diamanda Rigas, Cameron Fraser, Chendi Li, Hannah L. Archibald, Maria Gomez-Caraballo, Nicole Phan, Samantha J. Bilton, Daria Timonina, Sean Caenepeel, Faria M. Siddiqui, Varuna Nangia
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for these cancers may depend on their ability to potentiate the apoptotic response to chemother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::70abe6bdd9a6b3e57487dfcfd1b546b5
https://doi.org/10.1158/2159-8290.c.6547298.v1
https://doi.org/10.1158/2159-8290.c.6547298.v1
Autor:
Aaron N. Hata, Paul E. Hughes, Cyril H. Benes, Angela Coxon, Sean P. Brown, Kristopher A. Sarosiek, Justin F. Gainor, Christopher G. Azzoli, Anna F. Farago, Zofia Piotrowska, Lecia V. Sequist, Colleen Keyes, John H. Shin, Daniel P. Cahill, Kevin A. Raskin, Cameron D. Wright, Michael Lanuti, Lorin A. Ferris, Kristof Vajda, Diamanda Rigas, Cameron Fraser, Chendi Li, Hannah L. Archibald, Maria Gomez-Caraballo, Nicole Phan, Samantha J. Bilton, Daria Timonina, Sean Caenepeel, Faria M. Siddiqui, Varuna Nangia
Supplementary Figure 1-5, Supplementary Tables 1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d14dcf58051aa128a6d420a7ae16b05
https://doi.org/10.1158/2159-8290.22533896.v1
https://doi.org/10.1158/2159-8290.22533896.v1
Publikováno v:
Journal of Propulsion and Power. 38:84-96
Hybrid–electric powertrains offer the potential for performance improvements in unmanned aerial systems. However, for small unmanned aerial systems, potential gains in range and endurance can depen...
Autor:
Gwenaella Rescourio, Ana Z. Gonzalez, Salman Jabri, Brian Belmontes, Gordon Moody, Doug Whittington, Xin Huang, Sean Caenepeel, Mario Cardozo, Alan C. Cheng, David Chow, Hannah Dou, Adrie Jones, Ron C. Kelly, Yihong Li, Mike Lizarzaburu, Mei-Chu Lo, Rommel Mallari, Cesar Meleza, Yosup Rew, Scott Simonovich, Daqing Sun, Simon Turcotte, Xuelei Yan, Simon G. Wong, Evelyn Yanez, Manuel Zancanella, Jonathan Houze, Julio C. Medina, Paul E. Hughes, Sean P. Brown
Publikováno v:
Journal of Medicinal Chemistry. 62:10258-10271
Overexpression of the antiapoptotic protein Mcl-1 provides a survival advantage to some cancer cells, making inhibition of this protein an attractive therapeutic target for the treatment of certain types of tumors. Herein, we report our efforts towar
Autor:
Lorin A. Ferris, Kristof Vajda, Hannah L. Archibald, Daniel P. Cahill, Justin F. Gainor, Diamanda Rigas, Sean P. Brown, Anna F. Farago, Aaron N. Hata, Chendi Li, Cyril H. Benes, Kevin A. Raskin, Varuna Nangia, Michael Lanuti, Cameron D. Wright, John H. Shin, Kristopher A. Sarosiek, Lecia V. Sequist, Christopher G. Azzoli, Angela Coxon, Daria Timonina, Faria M. Siddiqui, Zofia Piotrowska, Paul E. Hughes, Sean Caenepeel, Cameron Fraser, Maria Gomez-Caraballo, Nicole Phan, Colleen Keyes, Samantha J. Bilton
Publikováno v:
Cancer Discovery. 8:1598-1613
BH3 mimetic drugs, which inhibit prosurvival BCL2 family proteins, have limited single-agent activity in solid tumor models. The potential of BH3 mimetics for these cancers may depend on their ability to potentiate the apoptotic response to chemother