Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Sean P Saunders"'
Autor:
Achilleas Floudas, Christopher D Cluxton, Julia Fahel, Adnan R Khan, Sean P Saunders, Sylvie Amu, Antonio Alcami, Padraic G Fallon
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0006012 (2017)
The helminth Schistosoma mansoni modulates the infected host's immune system to facilitate its own survival, by producing excretory/secretory molecules that interact with a variety of the host's cell types including those of the immune system. Herein
Externí odkaz:
https://doaj.org/article/2caae958a3194774b15aabc3ecabf88b
Autor:
Ruth Bone, Brian J Fennell, Amy Tam, Richard Sheldon, Karl Nocka, Sreeja Varghese, Chew Shun Chang, Heike C Hawerkamp, Aoife Yeow, Sean P Saunders, Emily Hams, Patrick T Walsh, Orla Cunningham, Padraic G Fallon
Publikováno v:
Antibody Therapeutics. 5:258-267
Background Interleukin (IL)25 has been implicated in tissue homeostasis at barrier surfaces and the initiation of type two inflammatory signaling in response to infection and cell injury across multiple organs. We sought to discover and engineer a hi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eed95ecf98910c10515eaea5f5988f79
https://doi.org/10.1093/abt/tbac022
https://doi.org/10.1093/abt/tbac022
Autor:
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille, Maria A. Curotto de Lafaille
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
IgE is an important mediator of protective immunity as well as allergic reaction, but how high affinity IgE antibodies are produced in memory responses is not clear. Here the authors show that IgE can be generated via class-switch recombination in Ig
Externí odkaz:
https://doaj.org/article/b0cb1457667e4bd2866daf4adcb12580
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The long-term effectiveness of antibody responses relies on the development of humoral immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete antigen-specific antibodies, and memory B cells that rapidly respond to antig
Externí odkaz:
https://doaj.org/article/84d322c9d5774a54a0246a1ca2b615d2
Autor:
Carlos J. Aranda, Edgar Gonzalez‐Kozlova, Sean P. Saunders, Weslley Fernandes‐Braga, Miyo Ota, Sriram Narayanan, Jin‐Shu He, Ester Del Duca, Bose Swaroop, Sacha Gnjatic, Gail Shattner, Joan Reibman, Nicholas A. Soter, Emma Guttman‐Yassky, Maria A. Curotto de Lafaille
Publikováno v:
AllergyREFERENCES.
Atopic diseases are characterized by IgE antibody responses that are dependent on cognate CD4 T cell help and T cell-produced IL-4 and IL-13. Current models of IgE cell differentiation point to the role of IgG memory B cells as precursors of pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833d91169215071533dc1afb2872aa9b
https://pubmed.ncbi.nlm.nih.gov/36445014
https://pubmed.ncbi.nlm.nih.gov/36445014
Autor:
Yin-Hu Wang, Lucile Noyer, Sascha Kahlfuss, Dimitrius Raphael, Anthony Y. Tao, Ulrike Kaufmann, Jingjie Zhu, Marisa Mitchell-Flack, Ikjot Sidhu, Fang Zhou, Martin Vaeth, Paul G. Thomas, Sean P. Saunders, Kenneth Stauderman, Maria A. Curotto de Lafaille, Stefan Feske
Publikováno v:
Science Advances. 8
T cell activation and function depend on Ca2+signals mediated by store-operated Ca2+entry (SOCE) through Ca2+release–activated Ca2+(CRAC) channels formed by ORAI1 proteins. We here investigated how SOCE controls T cell function in pulmonary inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c97f41a300cd2068b074b4e31d37468a
https://doi.org/10.1126/sciadv.abn6552
https://doi.org/10.1126/sciadv.abn6552
Autor:
Padraic G. Fallon, Tara Moran, Joan A. Geoghegan, Achilleas Floudas, Sean P. Saunders, Caoimhe M. R. Fahy, Michael Rooney, Ciara M. Byrne, Yoichiro Iwakura, Christian Schwartz
Publikováno v:
Allergy. 75:3216-3227
Background Atopic dermatitis (AD) is associated with a dysregulation of the skin barrier and may predispose to the development of secondary allergic conditions, such as asthma. Tmem79ma/ma mice harbor a mutation in the gene encoding Transmembrane Pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98fbbc361b31a9cb534aaf105908a7c4
https://doi.org/10.1111/all.14488
https://doi.org/10.1111/all.14488
Autor:
Jin-Shu He, Sharrada Subramaniam, Vipin Narang, Kandhadayar Srinivasan, Sean P. Saunders, Daniel Carbajo, Tsao Wen-Shan, Nur Hidayah Hamadee, Josephine Lum, Andrea Lee, Jinmiao Chen, Michael Poidinger, Francesca Zolezzi, Juan J. Lafaille, Maria A. Curotto de Lafaille
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
The originally published version of this Article contained errors in Fig. 4 that were introduced during the production process. In panel c, the two uppermost labels ‘IgE spleen’ and ‘IgE BM’ incorrectly read ‘IgG1 spleen’ and ‘IgE1 BM
Externí odkaz:
https://doaj.org/article/c034e958099243d49d5167842016b4be
Autor:
Luke A. J. O'Neill, Christian Schwartz, Achilleas Floudas, Patrick T. Walsh, McKenzie Anj., A Kaszlikowska, Yoichiro Iwakura, Alan D. Irvine, Tara Moran, Graham S. Ogg, Padraic G. Fallon, J Bom, Sean P. Saunders, Gabriel Núñez, Jocelyne Demengeot
Publikováno v:
Allergy
Background Atopic dermatitis (AD) is one of the most common skin diseases with a multifactorial etiology. Mutations leading to loss of skin barrier function are associated with the development of AD with group 2 innate lymphoid cells (ILC2) promoting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a91668da05304f4119177f50c7da295
https://doi.org/10.1111/all.13801
https://doi.org/10.1111/all.13801
Autor:
Padraic G. Fallon, Graham S. Ogg, Andrew N. J. McKenzie, James A. Johnston, Sean P. Saunders, Emily Hams, Denise C. Fitzgerald, Christian Schwartz, Patrick T. Walsh, Achilleas Floudas, Tara Moran
Publikováno v:
The Journal of Immunology. 199:707-717
Atopic dermatitis (AD) is a common inflammatory skin disease affecting up to 20% of children and 3% of adults worldwide and is associated with dysregulation of the skin barrier. Although type 2 responses are implicated in AD, emerging evidence indica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a1206170e750018ebfcb8afc2f36c61c
https://doi.org/10.4049/jimmunol.1602185
https://doi.org/10.4049/jimmunol.1602185