Zobrazeno 1 - 10
of 179
pro vyhledávání: '"Sean P McDonough"'
Autor:
Ching-Lin Hsieh, Christopher P Ptak, Andrew Tseng, Igor Massahiro de Souza Suguiura, Sean P McDonough, Tepyuda Sritrakul, Ting Li, Yi-Pin Lin, Richard E Gillilan, Robert E Oswald, Yung-Fu Chang
Publikováno v:
eLife, Vol 6 (2017)
Pathogens rely on proteins embedded on their surface to perform tasks essential for host infection. These obligatory structures exposed to the host immune system provide important targets for rational vaccine design. Here, we use a systematically des
Externí odkaz:
https://doaj.org/article/a50dc2ca412046858cd4e180b079cee2
Autor:
Ching-Lin Hsieh, Eric Chang, Andrew Tseng, Christopher Ptak, Li-Chen Wu, Chun-Li Su, Sean P McDonough, Yi-Pin Lin, Yung-Fu Chang
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004974 (2016)
The coagulation system provides a primitive but effective defense against hemorrhage. Soluble fibrinogen (Fg) monomers, composed of α, β and γ chains, are recruited to provide structural support for the formation of a hemostatic plug. Fg binds to
Externí odkaz:
https://doaj.org/article/2d627a81be0e4e7e93dd436e2f47215b
Autor:
Cuilian Ye, Weiwei Yan, Hua Xiang, Hongxuan He, Maosheng Yang, Muhammad Ijaz, Nicodemus Useh, Ching-Lin Hsieh, Patrick L McDonough, Sean P McDonough, Hussni Mohamed, Zhibang Yang, Yung-Fu Chang
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e111367 (2014)
Animal leptospirosis is one of the most common zoonotic diseases in the United States and around the world. In a previous study, we applied four recombinant antigens, rLipL21, rLoa22, rLipL32 and rLigACon4-8 of Leptospira interrogans (L. interrogans)
Externí odkaz:
https://doaj.org/article/b10a1c6196ae428391614024129b7972
Publikováno v:
PLoS ONE, Vol 8, Iss 11, p e78489 (2013)
C. difficile is the most common cause of nosocomial diarrhea in North America and Europe. Genomes of individual strains of C. difficile are highly divergent. To determine how divergent strains respond to environmental changes, the transcriptomes of t
Externí odkaz:
https://doaj.org/article/548b09a50d40490ba6aa010a309dfe16
Autor:
Syed M Faisal, Falong Yan, Tsai-Tzu Chen, Nicodemus M Useh, Shanguang Guo, Weiwei Yan, Shih-Jon Wang, Amy L Glaser, Sean P McDonough, Bhupinder Singh, Yung-Fu Chang
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70171 (2013)
Johnes disease (JD), caused by Mycobacterium avium subsp paratuberculosis (MAP), occurs worldwide as chronic granulomatous enteritis of domestic and wild ruminants. To develop a cost effective vaccine, in a previous study we constructed an attenuated
Externí odkaz:
https://doaj.org/article/8d55181d91954ce8b73fea714e04a82b
Autor:
Tavan Janvilisri, Joy Scaria, Ching-Hao Teng, Sean P McDonough, Robin D Gleed, Susan L Fubini, Sheng Zhang, Bruce Akey, Yung-Fu Chang
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e45608 (2012)
The impact of Clostridium difficile infection (CDI) on healthcare is becoming increasingly recognized as it represents a major cause of nosocomial diarrhea. A rising number of CDI cases and outbreaks have been reported worldwide. Here, we developed t
Externí odkaz:
https://doaj.org/article/2812e21210b64213b6010f26be331075
Autor:
Melanie Craven, Charlotte E Egan, Scot E Dowd, Sean P McDonough, Belgin Dogan, Eric Y Denkers, Dwight Bowman, Ellen J Scherl, Kenneth W Simpson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41594 (2012)
Understanding the interplay between genetic susceptibility, the microbiome, the environment and the immune system in Crohn's Disease (CD) is essential for developing optimal therapeutic strategies. We sought to examine the dynamics of the relationshi
Externí odkaz:
https://doaj.org/article/feaa802e85494aa29ee25d18035afc65
Autor:
Rajeev Raman, V Rajanikanth, Raghavan U M Palaniappan, Yi-Pin Lin, Hongxuan He, Sean P McDonough, Yogendra Sharma, Yung-Fu Chang
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14377 (2010)
BackgroundMany bacterial surface exposed proteins mediate the host-pathogen interaction more effectively in the presence of Ca²+. Leptospiral immunoglobulin-like (Lig) proteins, LigA and LigB, are surface exposed proteins containing Bacterial immuno
Externí odkaz:
https://doaj.org/article/5f2894d46a5b409ca0e3a74648b3ad6a
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e11301 (2010)
Leptospira spp. are pathogenic spirochetes that cause the zoonotic disease leptospirosis. Leptospiral immunoglobulin (Ig)-like protein B (LigB) contributes to the binding of Leptospira to extracellular matrix proteins such as fibronectin, fibrinogen,
Externí odkaz:
https://doaj.org/article/6756e043c8594233a2dff58a2cac5ed4
Autor:
Kira J. Noordwijk, Leyi Chen, Bianca D. Ruspi, Sydney Schurer, Brittany Papa, Diana C. Fasanello, Sean P. McDonough, Scott E. Palmer, Ian R. Porter, Parminder S. Basran, Eve Donnelly, Heidi L. Reesink
Publikováno v:
Animals, Vol 13, Iss 5, p 827 (2023)
Proximal sesamoid bone (PSB) fracture is the leading cause of fatal musculoskeletal injury in Thoroughbred racehorses in Hong Kong and the US. Efforts are underway to investigate diagnostic modalities that could help identify racehorses at increased
Externí odkaz:
https://doaj.org/article/30cd31fe2956443cb700772cbd5c6472