Výsledky vyhledávání - "Sean P Arlauckas"

Macrophage imaging and subset analysis using single-cell RNA sequencing

Autor: Ran Li, Sean P. Arlauckas, Nuri Oh, Miles A. Miller, Ralph Weissleder

Publikováno v: Nanotheranostics

Macrophages have been associated with drug response and resistance in diverse settings, thus raising the possibility of using macrophage imaging as a companion diagnostic to inform personalized patient treatment strategies. Nanoparticle-based contras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f131540d3df6318880aeea3784186f5
http://europepmc.org/articles/PMC7738942

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Arg1 expression defines immunosuppressive subsets of tumor-associated macrophages

Autor: Juhyun Oh, Christopher Garris, Rainer H. Kohler, Ralph Weissleder, Sean P. Arlauckas, Mikael J. Pittet, Seth B. Garren

Publikováno v: Theranostics

Tumor-associated macrophages (TAM) have attracted attention as they can modulate key cancer-related activities, yet TAM represent a heterogenous group of cells that remain incompletely characterized. In growing tumors, TAM are often referred to as M2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3cc97ab23dcd7c99e2581277e18faf0
https://doi.org/10.7150/thno.26888

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Imaging of cancer lipid metabolism in response to therapy

Autor: Elizabeth Anne Browning, Edward J. Delikatny, Sean P. Arlauckas, Harish Poptani

Publikováno v: NMR IN BIOMEDICINE

Lipids represent a diverse array of molecules essential to the cell's structure, defense, energy, and communication. Lipid metabolism can often become dysregulated during tumor development. During cancer therapy, targeted inhibition of cell prolifera

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2aa2c3d7c56513a21312b81b5a53f5
https://doi.org/10.1002/nbm.4070

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Successful anti-PD-1 cancer immunotherapy requires T cell-dendritic cell crosstalk involving the cytokines IFN-γ and IL-12

Publikováno v: Immunity, Vol. 49, No 6 (2018) pp. 1148-1161.e7
Immunity, vol 49, iss 6

Anti-PD-1 immune checkpoint blockers can induce sustained clinical responses in cancer but how they function invivo remains incompletely understood. Here, we combined intravital real-time imaging with single-cell RNA sequencing analysis and mouse mod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d5787de3e78427d24d8c7f74f926a1
https://europepmc.org/articles/PMC6301092/

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Recording the wild lives of immune cells

Autor: Sean P. Arlauckas, Ralph Weissleder, Mikael J. Pittet, Christopher Garris

Publikováno v: Science Immunology, Vol. 3, No 27 (2018) P. eaaq0491

Intravital microscopic imaging can uncover fundamental aspects of immune cell behavior in real time in both healthy and pathological states. Here, we discuss approaches for single-cell imaging of adaptive and innate immune cells to explore how they m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fec329850558df6ff35656e8cd3a9ed
https://europepmc.org/articles/PMC6771424/

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