Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Sean P, Kessler"'
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the chem
Externí odkaz:
https://doaj.org/article/7b10ae6b703340d6ae76c32b0be8610d
Autor:
Carol A. de la Motte, Sean P. Kessler
Publikováno v:
International Journal of Cell Biology, Vol 2015 (2015)
Hyaluronan is an abundant extracellular matrix component prevalent in the vertebrate intestinal tract. Here we discuss what is known about hyaluronan distribution during homeostasis and inflammatory diseases of the gut and discuss ways in which this
Externí odkaz:
https://doaj.org/article/5924746485534d959b4ba6d1222a50ba
Autor:
Saurabh Chattopadhyay, Sean P Kessler, Juliana Almada Colucci, Michifumi Yamashita, Preenie deS Senanayake, Ganes C Sen
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e87484 (2014)
Angiotensin-converting enzyme (ACE) regulates normal blood pressure and fluid homeostasis through its action in the renin-angiotensin-system (RAS). Ace-/- mice are smaller in size, have low blood pressure and defective kidney structure and functions.
Externí odkaz:
https://doaj.org/article/6d51dc5bc7434b909765965dc06cc17c
Autor:
Kourtney P Nickerson, Craig R Homer, Sean P Kessler, Laura J Dixon, Amrita Kabi, Ilyssa O Gordon, Erin E Johnson, Carol A de la Motte, Christine McDonald
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e101789 (2014)
In the latter half of the 20th century, societal and technological changes led to a shift in the composition of the American diet to include a greater proportion of processed, pre-packaged foods high in fat and carbohydrates, and low in dietary fiber
Externí odkaz:
https://doaj.org/article/1514363f40094ba4a92c127cae1639d9
Autor:
Kelly Weiss, Serpil C. Erzurum, Carole Bennett, Kewal Asosingh, Nicholas Wanner, Weiling Xu, Mario Alemagno, Sean P. Kessler, Matthew Frimel, Deborah A. Meyers, Chris D Lauruschkat
Publikováno v:
JCI Insight. 5
Inducible nitric oxide synthase (iNOS) and arginase-2 (ARG2) share a common substrate, arginine. Higher expression of iNOS and exhaled NO are linked to airway inflammation in patients. iNOS deletion in animal models suggests that eosinophilic inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::807fe59bc59301d71dddc39c7898e88a
https://doi.org/10.1172/jci.insight.127801
https://doi.org/10.1172/jci.insight.127801
Autor:
Zhongxin Yu, Hala Chaaban, Kathryn Burge, Aarthi Gunasekaran, Wei Zheng, Sean P. Kessler, Carol A. de la Motte, Jeffrey Eckert
Publikováno v:
Pediatr Res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc2d2f35158f056b7e0188f37bc2419f
https://pubmed.ncbi.nlm.nih.gov/31968356
https://pubmed.ncbi.nlm.nih.gov/31968356
Autor:
Aaron C. Petrey, Laura E. Nagy, Carol A. de la Motte, Yeojung Kim, Greeshma Ray, Claudio Fiocchi, Christine McDonald, Gail West, Michelle Suzanne Longworth, Sean P. Kessler
Publikováno v:
Matrix Biology. 66:93-109
Tight junction proteins are critical in maintaining homeostatic intestinal permeability. Multiple intestinal inflammatory diseases are correlated with reduced expression of tight junction proteins. We have recently reported that oral treatment of mic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2076a6bf2892eaa6cd486b1a80fecdd1
https://doi.org/10.1016/j.matbio.2017.09.003
https://doi.org/10.1016/j.matbio.2017.09.003
Autor:
Aaron C. Petrey, Sean P. Kessler, Christine McDonald, Kourtney P. Nickerson, Dana R. Obery, Carol A. de la Motte
Publikováno v:
Journal of Histochemistry & Cytochemistry. 66:273-287
Intestinal epithelium plays a critical role in host defense against orally acquired pathogens. Dysregulation of this protective barrier is a primary driver of inflammatory bowel diseases (Crohn’s and ulcerative colitis) and also infant gastrointest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee72f724093278f8b22e86404bc16b27
https://doi.org/10.1369/0022155417746775
https://doi.org/10.1369/0022155417746775
Autor:
Christine McDonald, Dana R. Obery, Craig R. Homer, Yeojung Kim, Sean P. Kessler, Carol A. de la Motte
Publikováno v:
Matrix Biology. 62:28-39
Maintaining a healthy intestinal barrier, the primary physical barrier between intestinal microbiota and the underlying lamina propria, is critical for optimal health. Epithelial integrity is essential for the prevention of the entrance of luminal co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3f55eb0925717b4f93131bd8e2195a5
https://doi.org/10.1016/j.matbio.2016.11.001
https://doi.org/10.1016/j.matbio.2016.11.001
Autor:
Zhongxin Yu, Aarthi Gunasekaran, Carol A. de la Motte, Sean P. Kessler, Wei Zheng, Hala Chaaban, Kathryn Burge, Jeffrey Eckert
Publikováno v:
Pediatric research
Background Disruption of tight junctions (TJs) predisposes to bacterial translocation, intestinal inflammation, and necrotizing enterocolitis (NEC). Previously, studies showed that hyaluronan (HA), a glycosaminoglycan in human milk, maintains intesti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2ce1bc3ccc641ea766122cedc7ba3fe
https://pubmed.ncbi.nlm.nih.gov/31499514
https://pubmed.ncbi.nlm.nih.gov/31499514