Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Sean McKay"'
Autor:
Bashayer R. Al-Mubarak, Karen F.S. Bell, Sudhir Chowdhry, Paul J. Meakin, Paul S. Baxter, Sean McKay, Owen Dando, Michael L.J. Ashford, Irina Gazaryan, John D. Hayes, Giles E. Hardingham
Publikováno v:
Redox Biology, Vol 47, Iss , Pp 102158- (2021)
The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection o
Externí odkaz:
https://doaj.org/article/bfac644fbd9a4a15bd392002c220b8e0
Autor:
Paul S. Baxter, Owen Dando, Katie Emelianova, Xin He, Sean McKay, Giles E. Hardingham, Jing Qiu
Publikováno v:
Cell Reports, Vol 34, Iss 12, Pp 108882- (2021)
Summary: Microglia, brain-resident macrophages, require instruction from the CNS microenvironment to maintain their identity and morphology and regulate inflammatory responses, although what mediates this is unclear. Here, we show that neurons and as
Externí odkaz:
https://doaj.org/article/7b47ef22b26b4f2292d57b8391827eec
Publikováno v:
Respiratory Medicine Case Reports, Vol 33, Iss , Pp 101465- (2021)
As of February 2020, over 2800 cases of lung injury associated with vapes have been reported in all 50 states (Cullen et al., 2019) [1]. This case is about a 29-year-old female with a five-year history of vaping tetrahydrocannabinol (THC) who present
Externí odkaz:
https://doaj.org/article/d6194a459be348f69ddf8829ca50a4c1
Autor:
Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C. Todd, Samuel Heron, Nóra M. Márkus, Jamie McQueen, David W. Hampton, Megan Torvell, Sachin S. Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J. A. Wyllie, T. Ian Simpson, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-18 (2017)
How neurons and neuronal activity regulate astrocyte functions is poorly understood. Haselet al. identify two large groups of astrocytic genes that are regulated by neuronal contact and synaptic activity respectively, with distinct roles in astrocyti
Externí odkaz:
https://doaj.org/article/f17cb8505a5e4abe82484929859194ff
Autor:
Sean McKay, Tomás J. Ryan, Jamie McQueen, Tim Indersmitten, Katie F.M. Marwick, Philip Hasel, Maksym V. Kopanitsa, Paul S. Baxter, Marc-André Martel, Peter C. Kind, David J.A. Wyllie, Thomas J. O’Dell, Seth G.N. Grant, Giles E. Hardingham, Noboru H. Komiyama
Publikováno v:
Cell Reports, Vol 25, Iss 4, Pp 841-851.e4 (2018)
Summary: The GluN2 subtype (2A versus 2B) determines biophysical properties and signaling of forebrain NMDA receptors (NMDARs). During development, GluN2A becomes incorporated into previously GluN2B-dominated NMDARs. This “switch” is proposed to
Externí odkaz:
https://doaj.org/article/dd3ab73865074c9fa7090b212b99cf6f
Autor:
Jamie McQueen, Tomás J Ryan, Sean McKay, Katie Marwick, Paul Baxter, Sarah M Carpanini, Thomas M Wishart, Thomas H Gillingwater, Jean C Manson, David J A Wyllie, Seth G N Grant, Barry W McColl, Noboru H Komiyama, Giles E Hardingham
Publikováno v:
eLife, Vol 6 (2017)
Aberrant NMDA receptor (NMDAR) activity contributes to several neurological disorders, but direct antagonism is poorly tolerated therapeutically. The GluN2B cytoplasmic C-terminal domain (CTD) represents an alternative therapeutic target since it pot
Externí odkaz:
https://doaj.org/article/f177a251648f4e64b60117c9b4f5e466
Autor:
Philip Hasel, Owen Dando, Zoeb Jiwaji, Paul Baxter, Alison C. Todd, Samuel Heron, Nóra M. Márkus, Jamie McQueen, David W. Hampton, Megan Torvell, Sachin S. Tiwari, Sean McKay, Abel Eraso-Pichot, Antonio Zorzano, Roser Masgrau, Elena Galea, Siddharthan Chandran, David J. A. Wyllie, T. Ian Simpson, Giles E. Hardingham
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-1 (2018)
Nature Communications 8: Article number: 15132 (2017); Published: 2 May 2017; Updated: 6 February 2018 Michel Goedert, who developed the Thy1-P301S transgenic mouse, was inadvertently omitted from the Acknowledgments section of this Article. The Ackn
Externí odkaz:
https://doaj.org/article/3b659f00935647d295544e72d73812da
Publikováno v:
Journal of Bronchology & Interventional Pulmonology. 28:e4-e7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d0344c35d9d339d971298844718be81
https://doi.org/10.1097/lbr.0000000000000694
https://doi.org/10.1097/lbr.0000000000000694
Publikováno v:
Flexible Bronchoscopy. :207-219
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b6a0d98e88315d1654222d7633057f6f
https://doi.org/10.1002/9781119389231.ch15
https://doi.org/10.1002/9781119389231.ch15
Autor:
Paul Baxter, Paul J. Meakin, John D. Hayes, Sudhir Chowdhry, Irina Gazaryan, Owen Dando, Giles E. Hardingham, Michael L.J. Ashford, Karen F.S. Bell, Sean McKay, Bashayer Al-Mubarak
Publikováno v:
Al-Mubarak, B, Bell, K, Chowdhry, S, Meakin, P J, Baxter, P, Mckay, S, Dando, O, Ashford, M L J, Gazaryan, I, Hayes, J D & Hardingham, G E 2021, ' Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress ', Redox biology . https://doi.org/10.1016/j.redox.2021.102158
Redox Biology, Vol 47, Iss, Pp 102158-(2021)
Redox Biology
Redox Biology, Vol 47, Iss, Pp 102158-(2021)
Redox Biology
The transcription factor Nrf2 is a stress-responsive master regulator of antioxidant, detoxification and proteostasis genes. In astrocytes, Nrf2-dependent gene expression drives cell-autonomous cytoprotection and also non-cell-autonomous protection o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::667bc3004cb3513c3802be1a21560f42
https://hdl.handle.net/20.500.11820/4131380c-cf23-4e17-bd95-0adb0385adbb
https://hdl.handle.net/20.500.11820/4131380c-cf23-4e17-bd95-0adb0385adbb
