Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sean McCutcheon"'
Autor:
Antonio Cibelli, David Ballesteros-Gomez, Sean McCutcheon, Greta L. Yang, Ashley Bispo, Michael Krawchuk, Giselle Piedra, David C. Spray
Publikováno v:
iScience, Vol 27, Iss 6, Pp 110069- (2024)
Summary: Astrocyte endfeet enwrap brain vasculature, forming a boundary for perivascular glymphatic flow of fluid and solutes along and across the astrocyte endfeet into the brain parenchyma. We evaluated astrocyte sensitivity to shear stress generat
Externí odkaz:
https://doaj.org/article/e785a16960634e1ab01957d07650810f
Autor:
Michael Brown, Scott Antonia, Smita Nair, Sean McCutcheon, Adam Swartz, Alejandro Barrera, Christian McRoberts Amador, Keith Siklenka, Lucas Humayun, James Isaacs, Timothy Reddy, Charles Gersbach
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/de1cb20287f94071a7869ee4a3925d0e
Autor:
Antonio Cibelli, Sandra Veronica Lopez-Quintero, Sean Mccutcheon, Eliana Scemes, David C. Spray, Randy F. Stout, Sylvia O. Suadicani, Mia M. Thi, Marcia Urban-Maldonado
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 15 (2021)
We transduced mouse cortical astrocytes cultured from four litters of embryonic wildtype (WT) and connexin43 (Cx43) null mouse pups with lentiviral vector encoding hTERT and measured expression of astrocyte-specific markers up to passage 10 (p10). Th
Externí odkaz:
https://doaj.org/article/8040b483b6574b3d9e818fbff5a9e81b
Autor:
David C. Spray, Sean McCutcheon
Supplementary Data from Glioblastoma–Astrocyte Connexin 43 Gap Junctions Promote Tumor Invasion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1261dc3562af3f7fc5add2ba8d09f968
https://doi.org/10.1158/1541-7786.22528080
https://doi.org/10.1158/1541-7786.22528080
Autor:
David C. Spray, Sean McCutcheon
Publikováno v:
Mol Cancer Res
Glioblastoma multiforme (GBM), classified as World Health Organization grade IV astrocytoma, is the deadliest adult cancer of the central nervous system. An important contributing factor to poor survival rates in GBM is extensive invasion, which decr
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-18 (2020)
Scientific Reports
Scientific Reports
Gap junction (GJ) channels permit molecules, such as ions, metabolites and second messengers, to transfer between cells. Their function is critical for numerous cellular interactions. GJ channels are composed of Connexin (Cx) hexamers paired across e
Autor:
David C. Spray, Sean McCutcheon
Publikováno v:
Cancer Research. 81:2885-2885
Background: Glioblastoma multiforme (GBM) invasion occurs along vasculature, and intercellular communication between glioma cells and the astrocyte endfoot may manipulate astrocytes to repress cell-matrix adhesion through transfer of miRNAs. Intercel
Publikováno v:
J Bone Miner Res
Localized apoptosis of osteocytes, the tissue-resident cells within bone, occurs with fatigue microdamage and activates bone resorption. Osteoclasts appear to target and remove dying osteocytes, resorbing damaged bone matrix as well. Osteocyte apopto
Publikováno v:
Biomedical Microdevices. 19
Many cell types communicate by means of dendritic extensions via a multi-tiered set of geometric and chemical cues. Until recently, mimicking the compartmentalized in vivo cellular environment of dendrite-expressing cells such as osteocytes and motor
Autor:
Robert J. Majeska, Maribel Vazquez, Stephen Redenti, Ankush Thakur, Uchenna Unachukwu, Sean McCutcheon
Publikováno v:
Cell adhesionmigration. 11(1)
Central nervous system (CNS) cells cultured in vitro as neuroclusters are useful models of tissue regeneration and disease progression. However, the role of cluster formation and collective migration of these neuroclusters to external stimuli has bee