Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Sean Marrache"'
Autor:
Peter Finnegan, Bruce Adams, Daniel Reyes, Sean Marrache, Payam Shahi, FuNien Tsai, Thomas Vollbrecht, Micheal Stubbington
Publikováno v:
Regular and Young Investigator Award Abstracts.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d48bed9650826fd97cd680bcf22bc16
https://doi.org/10.1136/jitc-2022-sitc2022.0924
https://doi.org/10.1136/jitc-2022-sitc2022.0924
Autor:
Michael JT Stubbington, Bruce Adams, Daniel Reyes, Ariel Royall, Maengseok Song, Sean Marrache, Payam Shahi, FuNien Tsai, Peter Finnegan, Thomas Vollbrecht, Tanmayee Khadilkar, David Jaffe, Ravi Ramenani, Wyatt McDonnell
Publikováno v:
The Journal of Immunology. 208:173.09-173.09
A more complete understanding of immune responses to disease requires consideration of multiple different cell types across both the innate and adaptive branches of the immune system along with the detection of many different analytes. We used Barcod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19859a65f179a78cf9cf73416d7a51b3
https://doi.org/10.4049/jimmunol.208.supp.173.09
https://doi.org/10.4049/jimmunol.208.supp.173.09
Autor:
Michael JT Stubbington, Bruce Adams, Daniel Reyes, Ariel Royall, Maengseok Song, Sean Marrache, Payam Shahi, FuNien Tsai, Peter Finnegan, Thomas Vollbrecht, Tanmayee Khadilkar, David Jaffee, Ravi Ramenani, Wyatt McDonnell
Publikováno v:
The Journal of Immunology. 208:116.09-116.09
Humans who have recovered from infectious disease possess a memory B cell pool that contains highly-potent antibodies against the cleared pathogenic agent. This pool is a valuable source of therapeutic antibodies but identifying these requires a meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16c87edb6b88efed42dafba4aa149c8b
https://doi.org/10.4049/jimmunol.208.supp.116.09
https://doi.org/10.4049/jimmunol.208.supp.116.09
Autor:
Sau Wai Hung, Hardik Mody, Sean Marrache, Yangzom D Bhutia, Franklin Davis, Jong Hyun Cho, Jason Zastre, Shanta Dhar, Chung K Chu, Rajgopal Govindarajan
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e71196 (2013)
We evaluated the potential of an investigational histone methylation reversal agent, 3-deazaneplanocin A (DZNep), in improving the chemosensitivity of pancreatic cancer to nucleoside analogs (i.e., gemcitabine). DZNep brought delayed but selective cy
Externí odkaz:
https://doaj.org/article/f4d6a8385eaa4032b590cec30340474a
Autor:
Anil Kumar, Shanta Dhar, Elizabeth W. Howerth, Sean Marrache, Bhabatosh Banik, Nagesh Kolishetti, Ru Wen
Atherosclerosis, the deadliest disease in the United States, arises due to the build up of plaques in the arteries as a result of excessive cholesterol deposition and an impaired cholesterol removal process. High density lipoproteins (HDL), popularly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::150e3569ec930f73b168c05a735b2bc6
https://europepmc.org/articles/PMC5744677/
https://europepmc.org/articles/PMC5744677/
Autor:
Shanta Dhar, Sean Marrache
Publikováno v:
Chemical Science
Mitochondrial delivery of 3-bromopyruvate for metabolic reprogramming of cancer cells.
A key hallmark of many aggressive cancers is accelerated glucose metabolism. The enzymes that catalyze the first step of glucose metabolism are hexokinases. E
A key hallmark of many aggressive cancers is accelerated glucose metabolism. The enzymes that catalyze the first step of glucose metabolism are hexokinases. E
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f06cce3f1e8b14c469744b5137558eaf
https://doi.org/10.1039/c4sc01963f
https://doi.org/10.1039/c4sc01963f
Publikováno v:
Proceedings of the National Academy of Sciences. 111:10444-10449
Chemoresistance of cisplatin therapy is related to extensive repair of cisplatin-modified DNA in the nucleus by the nucleotide excision repair (NER). Delivering cisplatin to the mitochondria to attack mitochondrial genome lacking NER machinery can le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5cf013f43c908e8e339f8540e0fd068
https://doi.org/10.1073/pnas.1405244111
https://doi.org/10.1073/pnas.1405244111
Publikováno v:
ACS Chemical Biology
Tumor growth is fueled by the use of glycolysis, which normal cells use only in the scarcity of oxygen. Glycolysis makes tumor cells resistant to normal death processes. Targeting this unique tumor metabolism can provide an alternative strategy to se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c2d775c3128ea7baaa0a6603693fa4a
https://doi.org/10.1021/cb400944y
https://doi.org/10.1021/cb400944y
Publikováno v:
Angewandte Chemie International Edition. 53:1963-1967
Cancer-associated inflammation induces tumor progression to the metastatic stage, thus indicating that a chemo-anti-inflammatory strategy is of interest for the management of aggressive cancers. The platinum(IV) prodrug Platin-A was designed to relea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e7363779d88bde9ced8df819ee377f5
https://doi.org/10.1002/anie.201308899
https://doi.org/10.1002/anie.201308899
Autor:
Shanta Dhar, Sean Marrache
Publikováno v:
Proceedings of the National Academy of Sciences. 109:16288-16293
Mitochondrial dysfunctions cause numerous human disorders. A platform technology based on biodegradable polymers for carrying bioactive molecules to the mitochondrial matrix could be of enormous potential benefit in treating mitochondrial diseases. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::009e47648dcc6c7917b9bb552f502fa3
https://doi.org/10.1073/pnas.1210096109
https://doi.org/10.1073/pnas.1210096109