Zobrazeno 1 - 10
of 304
pro vyhledávání: '"Sean MacKay"'
Akademický článek
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Autor:
Dan Li, Ruixue Wang, Tianyuzhou Liang, Hua Ren, Chaelee Park, Chin-Hsien Tai, Weiming Ni, Jing Zhou, Sean Mackay, Elijah Edmondson, Javed Khan, Brad St Croix, Mitchell Ho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Rational design of chimeric antigen receptor T (CAR-T) cells based on the recognition of antigenic epitopes capable of evoking the most potent CAR activation is an important objective in optimizing immune therapy. In solid tumors, the B7-H3
Externí odkaz:
https://doaj.org/article/d633e7c59ca149f7b0f28503297c8880
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.
Autor:
Nan Li, Alex Quan, Dan Li, Jiajia Pan, Hua Ren, Gerard Hoeltzel, Natalia de Val, Dana Ashworth, Weiming Ni, Jing Zhou, Sean Mackay, Stephen M. Hewitt, Raul Cachau, Mitchell Ho
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Glypican-1 (GPC1) expression is elevated in pancreatic cancer and has been exploited as a therapeutic target. Here the authors report the development of VHH nanobody-based CAR-T cells targeting GPC1, showing anti-tumor activity in pancreatic cancer p
Externí odkaz:
https://doaj.org/article/a61d87f106544eda8b190f53207ab475
Publikováno v:
BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-15 (2022)
Abstract Background COVID-19 presented an unprecedented global public health challenge because of its rapid and relentless spread, and many countries instituted lockdowns to prevent the spread of infection. Although this strategy may have been approp
Externí odkaz:
https://doaj.org/article/b97a847d3f154cb987f0fc9246f48899
Publikováno v:
Case Reports in Surgery, Vol 2023 (2023)
Bochdalek hernias (BHs) are rare, and the presentation, diagnosis, and management of them can be complex. We present a 70-year-old man presenting with left flank pain who underwent a successful laparoscopic repair of BH with mesh placement.
Externí odkaz:
https://doaj.org/article/94ea04694d804ef6b28d02cf51e108f7
Autor:
Payal Dhar, Fahmin Basher, Zhe Ji, Lei Huang, Si Qin, Derek A. Wainwright, Jerid Robinson, Shaye Hagler, Jing Zhou, Sean MacKay, Jennifer D. Wu
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)
Dhar et al used primary human and mouse natural killer (NK) cells to demonstrate that tumor-derived NKG2D ligand soluble MIC (sMIC) can reprogram the NK cells to secrete pro-tumorigenic cytokines with diminished cytotoxicity and polyfunctional potent
Externí odkaz:
https://doaj.org/article/0aee9ce5734644cbbebb591f8c4256a4
Autor:
Shelli Farhadian, Laura R. Glick, Chantal B. F. Vogels, Jared Thomas, Jennifer Chiarella, Arnau Casanovas-Massana, Jing Zhou, Camila Odio, Pavithra Vijayakumar, Bertie Geng, John Fournier, Santos Bermejo, Joseph R. Fauver, Tara Alpert, Anne L. Wyllie, Cynthia Turcotte, Matthew Steinle, Patrick Paczkowski, Charles Dela Cruz, Craig Wilen, Albert I. Ko, Sean MacKay, Nathan D. Grubaugh, Serena Spudich, Lydia Aoun Barakat
Publikováno v:
BMC Neurology, Vol 20, Iss 1, Pp 1-5 (2020)
Abstract Background COVID-19 is caused by the severe acute respiratory syndrome virus SARS-CoV-2. It is widely recognized as a respiratory pathogen, but neurologic complications can be the presenting manifestation in a subset of infected patients. Ca
Externí odkaz:
https://doaj.org/article/8fa8f917d95e432aa0c08cf431776d87
Autor:
Giulia Parisi, Justin D. Saco, Felix B. Salazar, Jennifer Tsoi, Paige Krystofinski, Cristina Puig-Saus, Ruixue Zhang, Jing Zhou, Gardenia C. Cheung-Lau, Alejandro J. Garcia, Catherine S. Grasso, Richard Tavaré, Siwen Hu-Lieskovan, Sean Mackay, Jonathan Zalevsky, Chantale Bernatchez, Adi Diab, Anna M. Wu, Begoña Comin-Anduix, Deborah Charych, Antoni Ribas
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Adoptive cell transfer (ACT) of T cells for tumor treatment often requires IL-2 administration. Here, the authors show that a modified IL-2 cytokine (NKTR-214) can outperform IL-2 in a melanoma mouse model.
Externí odkaz:
https://doaj.org/article/26da1a14c88d4cdbbb1ebbe52eeb9731
