Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sean M. Silverman"'
Autor:
Wenxin Ma, Sean M Silverman, Lian Zhao, Rafael Villasmil, Maria M Campos, Juan Amaral, Wai T Wong
Publikováno v:
eLife, Vol 8 (2019)
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation. H
Externí odkaz:
https://doaj.org/article/552f31660e154a1ca8bfc2da4ded84f7
Publikováno v:
The Journal of Experimental Medicine
Silverman et al. demonstrate that complement activation features prominently in retinitis pigmentosa in close association with activated microglia. This response mediates adaptive neuroprotection for photoreceptors by facilitating a C3-CR3–dependen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af69aa82ff3bb2d92cedb5c3e7d4d38
https://doi.org/10.1084/jem.20190009
https://doi.org/10.1084/jem.20190009
Autor:
Sean M, Silverman, Wai T, Wong
Publikováno v:
Advances in experimental medicine and biology. 1185
The complement system, commonly associated with innate immune responses to invading pathogens, has been found in the CNS to exert a host of noncanonical functions influential during development and disease. In the retina, local complement expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2cccdb84c429df71dc66ad8cce2f811e
https://pubmed.ncbi.nlm.nih.gov/31884585
https://pubmed.ncbi.nlm.nih.gov/31884585
Autor:
Wai T. Wong, Sean M. Silverman
Publikováno v:
Retinal Degenerative Diseases ISBN: 9783030273774
The complement system, commonly associated with innate immune responses to invading pathogens, has been found in the CNS to exert a host of noncanonical functions influential during development and disease. In the retina, local complement expression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::904ed16500281853976dabfa93cb1460
https://doi.org/10.1007/978-3-030-27378-1_6
https://doi.org/10.1007/978-3-030-27378-1_6
Autor:
Sean M. Silverman, Rafael Villasmil, Lian Zhao, Maria M Campos, Wai T. Wong, Juan Amaral, Wenxin Ma
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
Constitutive TGFβ signaling is important in maintaining retinal neurons and blood vessels and is a factor contributing to the risk for age-related macular degeneration (AMD), a retinal disease involving neurodegeneration and microglial activation. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f38f9ca36f7943ae49b5c01f64d88be
https://elifesciences.org/articles/42049
https://elifesciences.org/articles/42049
Complement activation has been implicated as an inflammatory driver of neurodegeneration in retinal and brain pathologies. However, its involvement and influence of photoreceptor degeneration in retinitis pigmentosa (RP), an inherited, largely incura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae215ea470680dd6662682c6dccd837
Autor:
Sean M. Silverman, Wai T. Wong
Publikováno v:
Annual review of vision science. 4
Microglia, the primary resident immune cell type, constitute a key population of glia in the retina. Recent evidence indicates that microglia play significant functional roles in the retina at different life stages. During development, retinal microg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7a0c9fef21d6441792e3f158316eee
https://pubmed.ncbi.nlm.nih.gov/29852094
https://pubmed.ncbi.nlm.nih.gov/29852094
Autor:
Liping Tang, Abbot F. Clark, Yang Liu, Sean M. Silverman, Byung Jin Kim, Ning Fan, Xizhen Wang, Xuyang Liu, Iok-Hou Pang
Publikováno v:
Experimental eye research. 161
Oxidative injuries, such as those related to reactive oxygen species (ROS), have been implicated in various retinal and optic nerve disorders. Many ROS detection methods have been developed. Although widely utilized, many of these methods are useful
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c07c11ea9f1c3c5b6c42d2b5d49952d2
https://pubmed.ncbi.nlm.nih.gov/28603016
https://pubmed.ncbi.nlm.nih.gov/28603016
Autor:
Robert J. Wordinger, Yang Liu, Iok-Hou Pang, Sean M. Silverman, Byung Jin Kim, Abbot F. Clark
Publikováno v:
Molecular Neurodegeneration
Background The c-Jun N-terminal kinase (JNK) signaling pathway plays an important role in neuronal pathophysiology. Using JNK inhibitors, we examined involvement of the JNK pathway in cultured rat retinal ganglion cell (RGC) death and in mouse retina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00e709372ff46b68b251d156bd88595f
https://doi.org/10.1186/s13024-016-0093-4
https://doi.org/10.1186/s13024-016-0093-4