Pharmacological inhibition of Ras-transformed epithelial cell growth is linked to down-regulation of epidermal growth factor–related peptides

Autor: Sean M. Oldham, Adrienne D. Cox, Nywana Sizemore, Robert J. Coffey, John A. Barnard, Channing J. Der, Evangeline R Reynolds

Publikováno v: Gastroenterology. 117:567-576

Background & Aims: Posttranslational farnesylation is required for Ras activation. Farnesyl transferase inhibitors (FTIs) selectively block protein farnesylation and reduce the growth of many Ras-transformed cells in vitro and in vivo. Activated Ras

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfbb39b4926ae915db3980bc07ec518
https://doi.org/10.1016/s0016-5085(99)70449-x

Contributors

Autor: Muhanned Abu-Hijleh, Enrique Aguilar, Sonia Ancoli-Israel, Melissa K. Andrew, Wilbert S. Aronow, Lodovico Balducci, Mario Barbagallo, Antony Bayer, Ceri Beaton, Paul E. Belchetz, Steven L. Berk, Ravi S. Bhat, Arnab Bhowmick, Italo Biaggioni, Simon G. Biggs, David A. Black, Harrison G. Bloom, Charlotte E. Bolton, Julie Blaskewicz Boron, Clive Bowman, Sidney S. Braman, Lawrence J. Brandt, Roberta Diaz Brinton, Scott E. Brodie, Gina Browne, Patricia Bruckenthal, Andrew K. Burroughs, Robert N. Butler, Richard Camicioli, Ian A. Campbell, Robert Victor, Margred Capel, Harvinder S. Chahal, Herman S. Cheung, Sean D. Christie, Duncan S. Cole, Claudia Cooper, Tara K. Cooper, Richard A. Cowie, Peter Crome, Simon C.M. Croxson, Stuti Dang, Gwyneth A. Davies, Timothy J. Doherty, Ligia J. Dominguez, William M. Drake, Eamonn Eeles, William B. Ershler, William J. Evans, Martin R. Farlow, Richard C. Feldstein, Howard M. Fillit, Andrew Y. Finlay, Ilora Finlay, Roger M. Francis, Anthony J. Freemont, James E. Galvin, Nicholas J.R. George, Neil D. Gillespie, Robert Glickman, Adam G. Golden, Leslie B. Gordon, Michelle Gorenstein, Margot A. Gosney, John Trevor Green, David A. Greenwald, Celia L. Gregson, Michael L. Gruber, David R.P. Guay, Renato Maia Guimarães, Khalid Hamandi, Peter Hammond, Steven M. Handler, Joseph T. Hanlon, Malene Hansen, Danielle Harari, Mujtaba Hasan, George A. Heckman, Paul Higgs, David B. Hogan, Søren Holm, Ben Hope-Gill, Susan E. Howlett, Ruth E. Hubbard, Joanna Hurley, C. Shanthi Johnson, Larry E. Johnson, Bindu Kanapuru, Rosalie A. Kane, Cornelius Katona, Seymour Katz, Horacio Kaufmann, Nicholas A. Kefalides, Heather H. Keller, Rose Anne Kenny, Thomas B.L. Kirkwood, Brandon Koretz, Mark A. Kosinski, Kenneth J. Koval, George A. Kuchel, Chao-Qiang Lai, W. Clark Lambert, Alexander Lapin, Myrna I. Lewis, Stuart A. Lipton, Gill Livingston, Jorge H. Lopez, Mary V. Macneil, Robert L. Maher, Jill Manthorpe, Kenneth G. Manton, Bryan Markinson, Maureen F. Markle-Reid, Jane Martin, Edward J. Masoro, Charles N. Mccollum, Michael A. Mcdevitt, Bruce S. Mcewen, Jolyon Meara, Myron Miller, Arnold Mitnitski, Paige A. Moorhouse, John E. Morley, Latana A. Munang, James W. Myers, Tomohiro Nakamura, James Nazroo, Michael W. Nicolle, Sean M. Oldham, Jose M. Ordovas, Joseph G. Ouslander, James T. Pacala, Laurence D. Parnell, Gopal A. Patel, Thomas T. Perls, Thanh G. Phan, Katie Pink, Valerie M. Pomeroy, John F. Potter, Malcolm C.A. Puntis, Gangaram Ragi, Holly J. Ramsawh, M. Shawkat Razzaque, David B. Reuben, Kenneth Rockwood, Christopher A. Rodrigues, Yves Rolland, Bernard A. Roos, Sonja Rosen, David H. Rosenbaum, Philip A. Routledge Obe, Laurence Z. Rubenstein, Lisa V. Rubenstein, Gordon Sacks, Gerry J.F. Saldanha, Luis F. Samos, Mary Sano, Robert Santer, K. Warner Schaie, Kenneth E. Schmader, Andrea Schreiber, Robert A. Schwartz, David L. Scott, null Sewell, D. Gwyn Seymour, Krupa Shah, Hamsaraj G.M. Shetty, Felipe Sierra, Alan J. Sinclair, Kristel Sleegers, Oliver Milling Smith, Phillip P. Smith, Velandai K. Srikanth, John M. Starr, Richard G. Stefanacci, Paul Stolee, Michael Stone, Bryan D. Struck, Allan D. Struthers, Stephanie A. Studenski, Dennis H. Sullivan, Rawan Tarawneh, Dennis D. Taub, Robert E. Tepper, Ladora V. Thompson, Amanda G. Thrift, Anthea Tinker, Mohan K. Tummala, Jane Turton, Christine Van Broeckhoven, Bruno Vellas, Norman Vetter, Emma C. Veysey, Andrew Vigario, Dennis T. Villareal, Oleg Volkov, Adrian Wagg, Arnold Wald, Marion F. Walker, Katherine Ward, Huber R. Warner, Barbara E. Weinstein, Sherry L. Willis, Miles D. Witham, Jean Woo, Kenneth Woodhouse, Elias Xirouchakis, John Young, Zahra Ziaie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2ec6d1feb663e3d7a4d207781555978f
https://doi.org/10.1016/b978-1-4160-6231-8.10131-x

Ras, but not Src, transformation of RIE-1 epithelial cells is dependent on activation of the mitogen-activated protein kinase cascade

Autor: Sean M. Oldham, Nywana Sizemore, Robert J. Coffey, Evangeline R Reynolds, Adrienne D. Cox, Channing J. Der

Publikováno v: Oncogene. 16(20)

Src transformation of NIH3T3 mouse fibroblasts has been shown to be dependent on Ras function. Since we recently showed that the signaling pathways that mediate Ras transformation of RIE-1 rat intestinal epithelial cells are distinct from those that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9317460ecf8c1a51bf53d0cad7265d1
https://pubmed.ncbi.nlm.nih.gov/9632133

Activation of the Raf-1/MAP kinase cascade is not sufficient for Ras transformation of RIE-1 epithelial cells

Autor: Sean M. Oldham, Lisa M. Gangarosa, Robert J. Coffey, Geoffrey J. Clark, Channing J. Der

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 93(14)

The potent transforming activity of membrane-targeted Raf-1 (Raf-CAAX) suggests that Ras transformation is triggered primarily by a Ras-mediated translocation of Raf-1 to the plasma membrane. However, whereas constitutively activated mutants of Ras [

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783de5eb1c99f00b0415df3bf63b15cb
https://pubmed.ncbi.nlm.nih.gov/8692920