Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sean M. O'Donnell"'
Publikováno v:
RNA. 18:508-518
The bacteriophage λ's cI mRNA was utilized to examine the importance of the 5′-terminal phosphate on expression of leadered and leaderless mRNA in Escherichia coli. A hammerhead ribozyme was used to produce leadered and leaderless mRNAs, in vivo a
Autor:
Erik S. Barton, Barbara Sherry, Jeffrey N. Rottman, Mark W. Hansberger, Janene Pierce, J. Denise Wetzel, Timothy S. Blackwell, Jodi L. Connolly, Terence S. Dermody, Melissa J. Watson, Wei Han, James D. Chappell, Sean M. O'Donnell, Tibor Valyi-Nagy, J. Craig Forrest, Fiona E. Yull
Publikováno v:
Journal of Clinical Investigation. 115:2341-2350
Reovirus induces apoptosis in cultured cells and in vivo. In cell culture models, apoptosis is contingent upon a mechanism involving reovirus-induced activation of transcription factor NF-kappaB complexes containing p50 and p65/RelA subunits. To expl
Autor:
Erik S. Barton, Sean M. O'Donnell, Tibor Valyi-Nagy, Terence S. Dermody, Kenneth L. Tyler, Christine Robinson, Jacquelyn A. Campbell, Penny Clarke, Maria L. Ibach, J. Denise Wetzel
Publikováno v:
The Journal of Infectious Diseases. 189:1664-1675
Mammalian reoviruses are non-enveloped viruses that contain a segmented, double-stranded RNA genome. Reoviruses infect most mammalian species, although infection with these viruses in humans is usually asymptomatic. We report the isolation of a novel
Publikováno v:
International Reviews of Immunology. 22:477-503
Mammalian reoviruses serve as important models for studies of viral replication and pathogenesis. These viruses have been isolated from many mammalian species, including humans, and cause disease primarily in the very young. Reoviruses induce apoptos
Publikováno v:
Journal of Nuclear Cardiology. 4:283-290
Similar to other99mTc-based infarct-avid agents,99mTc-glucarate localizes in myocardial infarcts. Whether severely ischemic viable myocytes sequester99mTc-glucarate is uncertain. To assess the infarct specificity, in vitro and in vivo studies were pe
Autor:
Ban-An Khaw, Vladimir S. Trubetskoy, Sean M. O'Donnell, Naseem Nossiff, Artiom Petrov, Sharon Khaw, Vladimir P. Torchilin, Jagat Narula
Publikováno v:
Journal of Nuclear Cardiology. 2:26-34
Background Cell surfaces and intercellular matrixes contain acidic residues, making them negatively charged. Antibodies are basic, positively charged glycoproteins. Therefore the potential for nonspecific ionic interaction exists, which could increas
Autor:
Vladimir P. Torchilin, Sean M. O'Donnell, Alexander L. Klibanov, Ban-An Khaw, Leaf Huang, Naseem Nossiff, Mikhail A. Slinkin
Publikováno v:
American Journal of Physiology-Heart and Circulatory Physiology. 261:60-65
Macromolecular carriers and liposomes were covalently coupled to monoclonal antibodies against cardiac myosin heavy chain. Deferoxamine-modified polymers bound tightly with 67Ga and68 Ga radioisotopes. Ternary deferoxamine-polylysine antibody conjuga
Autor:
Sean M. O'Donnell, Anthony L. Farone, J. Denise Wetzel, Mary B. Farone, Kristel M. Young, Janene Pierce, Terence S. Dermody, Chad S. Brooks
Publikováno v:
Viral immunology. 19(3)
Mammalian Orthoreoviruses are important models for studies of viral pathogenesis. In the rat lung, Reovirus strain type 3 Dearing (T3D) induces substantially more inflammation than does strain type 1 Lang (T1L). To better understand mechanisms underl
Autor:
Geoffrey H. Holm, Melissa J. Watson, Ravi S. Chari, Terence S. Dermody, Bing Tian, Sean M. O'Donnell, Allan R. Brasier, Dean W. Ballard, Janene Pierce
Publikováno v:
Journal of virology. 80(3)
Reovirus infection activates NF-kappaB, which leads to programmed cell death in cultured cells and in the murine central nervous system. However, little is known about how NF-kappaB elicits this cellular response. To identify host genes activated by
Autor:
Gary R. Janssen, Sean M. O'Donnell
Publikováno v:
Journal of bacteriology. 184(23)
By primer extension inhibition assays, 70S ribosomes bound with higher affinity, or stability, than did 30S subunits to leaderless mRNAs containing AUG or GUG start codons. Addition of translation initiation factors affected ribosome binding to leade