Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Sean M. Maddox"'
Publikováno v:
Chemical Science. 13:763-774
Here we report a new series of hydrolytically stable chemotype heteroaromatic azoline thioethers (HATs) to achieve highly selective, rapid, and efficient covalent labeling of cysteine under physiological conditions. Although the resulting cysteine-az
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7537f6e16e2531c0e669aaf83ab6c8
https://doi.org/10.1039/d1sc04139h
https://doi.org/10.1039/d1sc04139h
Publikováno v:
Journal of the American Chemical Society. 142:2198-2203
Diarylamines and related scaffolds are among the most common chemotypes in modern drug discovery. While they can potentially possess two chiral axes, there are no studies on their enantioselective ...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2d958e2cde74ec2101b0c1e07016ff4a
https://doi.org/10.1021/jacs.9b12994
https://doi.org/10.1021/jacs.9b12994
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:3421-3439
Compounds that react irreversibly with cysteines have reemerged as potent and selective tools for altering protein function, serving as chemical probes and even clinically approved drugs. The exquisite sensitivity of human immune cell signaling pathw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27ce9e1852a30c814abade77340073ab
https://doi.org/10.1016/j.bmc.2019.05.050
https://doi.org/10.1016/j.bmc.2019.05.050
Autor:
Christopher J. Nalbandian, Sagar D. Vaidya, Sean M. Maddox, Jeffrey L. Gustafson, Andrew N. Dinh, Mirza A. Saputra
Publikováno v:
The Journal of organic chemistry. 85(21)
We report a highly efficient ortho-selective electrophilic chlorination of phenols utilizing a Lewis basic selenoether catalyst. The selenoether catalyst resulted in comparable selectivities to our previously reported bis-thiourea ortho-selective cat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05f0957ca7034e1690e39d5013f1e296
https://pubmed.ncbi.nlm.nih.gov/33044067
https://pubmed.ncbi.nlm.nih.gov/33044067
Publikováno v:
J Am Chem Soc
Diarylamines are among the most common chemotypes in modern drug discovery. While diarylamines can potentially possess two axes of chirality, there are no studies on their catalytic enantioselective synthesis as these axes typically possess lower ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::59991ba6e2c4dca1e25f61209b1f1c5e
https://pubmed.ncbi.nlm.nih.gov/31944689
https://pubmed.ncbi.nlm.nih.gov/31944689
Autor:
Jeffrey L. Gustafson, Andrew N. Dinh, Sean T. Toenjes, Amy C. Jackson, Sean M. Maddox, Mirza A. Saputra, Ryan R. Noorbehesht
Publikováno v:
Synlett. 29:2155-2160
We report studies toward a small-molecule-catalytic approach to access atropisomeric diaryl ethers that proceeds through a C(sp2)–H alkylation using nitroalkanes as the alkyl source. A quaternary ammonium salt derived from quinine, containing a ste
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5893812a0cd86a31488f704c201573
https://doi.org/10.1055/s-0037-1609581
https://doi.org/10.1055/s-0037-1609581
Autor:
Jeffrey L. Gustafson, Nicholas C Rochester, Gregory A. Dawson, Arnold L. Rheingold, Sean M. Maddox, Curtis E. Moore, Arianna B Ayonon
Publikováno v:
ACS Catalysis. 8:5443-5447
We report a cinchona alkaloid catalyzed addition of thiophenol into rapidly interconverting aryl-naphthoquinones, resulting in stable biaryl atropisomers upon reductive methylation. An array of thiophenols and naphthoquinone substrates were evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787e786c906fda100075f363e73e0974
https://doi.org/10.1021/acscatal.8b00906
https://doi.org/10.1021/acscatal.8b00906
Autor:
Gregory A. Dawson, Sean M. Maddox, Maria A. Ortiz, Jeffrey L. Gustafson, Valeria Garcia, F. Javier Piedrafita, Sean T. Toenjes
Publikováno v:
ACS Chem Biol
Unstable atropisomerism is innate in many common scaffolds in drug discovery, commonly existing as freely rotating aryl-aryl bonds. Such compounds can access the majority of dihedral conformations around the bond axis; however, most small molecules b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e4d2bc84d17a55e5e1aa78962455d1
https://pubmed.ncbi.nlm.nih.gov/31424197
https://pubmed.ncbi.nlm.nih.gov/31424197
Autor:
Andrew N, Dinh, Ryan R, Noorbehesht, Sean T, Toenjes, Amy C, Jackson, Mirza A, Saputra, Sean M, Maddox, Jeffrey L, Gustafson
Publikováno v:
Synlett : accounts and rapid communications in synthetic organic chemistry. 29(16)
Herein we report studies towards a small molecule catalytic approach to access atropisomeric diaryl ethers that proceeds via a C(sp(2))-H alkylation using nitroalkanes as the alkyl source. A quaternary ammonium salt derived from quinine containing a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e804e5d239e53f0712cc4911bd0b98ab
https://pubmed.ncbi.nlm.nih.gov/31178629
https://pubmed.ncbi.nlm.nih.gov/31178629
Publikováno v:
Organic Letters. 18:5476-5479
Different catalysts are demonstrated to overcome or augment a substrate's innate regioselectivity. Nagasawa's bis-thiourea catalyst was found to overcome the innate para-selectivity of electrophilic phenol chlorination, yielding ortho-chlorinated phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c657a6f169ae9e8db96e18f24958531
https://doi.org/10.1021/acs.orglett.6b02650
https://doi.org/10.1021/acs.orglett.6b02650