Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sean M. Curtis"'
Autor:
Daniel A. Nichols, Daniel A. Nin, Sean M. Curtis, Joshua W. Major, Apurba K. Bhattacharjee, Clare E. Gutteridge, Lucia Gerena
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1048-1051
Investigation of a series of 2,N-bisarylated 2-ethoxyacetamides resulted in the identification of four inhibitors 5, 20, 24, 29 with single-digit micromolar in vitro efficacy against two drug-resistant Plasmodium falciparum strains. These compounds a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93b3e6f4743f25fd69a949e0e9b00cdc
https://doi.org/10.1016/j.bmcl.2015.12.032
https://doi.org/10.1016/j.bmcl.2015.12.032
Autor:
Joshua W. Major, Daniel A. Nin, Sean M. Curtis, Daniel A. Nichols, Apurba K. Bhattacharjee, Lucia Gerena, Clare E. Gutteridge
Publikováno v:
Letters in Organic Chemistry. 12:407-412
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17530c8934be5e34e2e39db6dc92128b
https://doi.org/10.2174/1570178612666150501004856
https://doi.org/10.2174/1570178612666150501004856
Autor:
Joshua W. Major, Daniel A. Nin, Clare E. Gutteridge, Sean M. Curtis, Daniel A. Nichols, Apurba K. Bhattacharjee, Lucia Gerena
Publikováno v:
ChemInform. 46
A series of new α-ethoxy-α-phenylacetamides and α-ethoxy-α-quinolinylacetamides is prepared from anthranilic acid in a simple and economical path.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e775c297f32959ab61026ab99f599f8
https://doi.org/10.1002/chin.201537075
https://doi.org/10.1002/chin.201537075
Publikováno v:
Crystal Growth & Design. 5:2313-2321
Crystals have been designed for the purpose of carrying out the topochemical polymerization of two isomeric dipyridyldiacetylenes, 1,4-di(pyrdin-3-yl)buta-1,3-diyne (3-pda) and 1,4-di(pyrdin-4-yl)buta-1,3-diyne (4-pda). A successful polymerization de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::69931d0703001766a5affaa31ffd222d
https://doi.org/10.1021/cg050204x
https://doi.org/10.1021/cg050204x
Autor:
Joseph W. Lauher, Xi Ouyang, Tam Luong Nguyen, Nam Le, Sean M. Curtis, Frank W. Fowler, Tritan Tran
Publikováno v:
Supramolecular Chemistry. 17:31-36
A series of five polydiacetylenes have been synthesized via topochemical polymerizations of the corresponding monomers. The requisite structural parameters for the polymerization were achieved by the use of a host–guest co-crystal strategy. The ato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e31eab4c19afa04a29537127e9a31da3
https://doi.org/10.1080/10610270412331328916
https://doi.org/10.1080/10610270412331328916
Autor:
Lisa Xie, Constance O. Asher, ThuLan Luong, Qigui Li, Daniel A. Nichols, Clare E. Gutteridge, Gettayacamin Montip, Michael P. Kozar, Sean M. Curtis, Darshan S. Thota, Jing Zhang, Victor Melendez, Lucia Gerena
Publikováno v:
Pharmacology. 87(1-2)
4′-n-Butoxy-2,4-dimethoxy-chalcone (MBC) has been described as protecting mice from an otherwise lethal infection with Plasmodium yoelii when dosed orally at 50 mg/kg/dose, daily for 5 days. In contrast, we found that oral dosing of MBC at 640 mg/k
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0f27818cc4d2a5134e9748ab4ca273
https://pubmed.ncbi.nlm.nih.gov/21282967
https://pubmed.ncbi.nlm.nih.gov/21282967
Autor:
Kirsten S. Smith, Lucia Gerena, Charles A. DiTusa, Daniel A. Nichols, Sean M. Curtis, Joseph V. Vo, Apurba K. Bhattacharjee, Clare E. Gutteridge, Darshan S. Thota, Constance O. Asher, Gettayacamin Montip, Damaris S. Diaz
Publikováno v:
Bioorganicmedicinal chemistry letters. 16(21)
Investigation of a series of 1-phenyl-3-aryl-2-propen-1-ones resulted in the identification of nine inhibitors with submicromolar efficacy against at least one Plasmodium falciparum strain in vitro. These inhibitors were inactive when given orally in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff767b8dc2ad9ae15c9228450aeb7fe3
https://pubmed.ncbi.nlm.nih.gov/16908136
https://pubmed.ncbi.nlm.nih.gov/16908136
Publikováno v:
Organic letters. 7(10)
Diiodobutadiyne (1) and diiodohexatriyne (2) form cocrystals with bispyridyl oxalamides and ureas, based on the halogen bond between the alkynyl iodine and pyridine nitrogen. In each cocrystal, the oxalamide or urea host forms one-dimensional hydroge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7f6703c62f0357abf3a996fae14b94f
https://pubmed.ncbi.nlm.nih.gov/15876012
https://pubmed.ncbi.nlm.nih.gov/15876012