Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Sean M. Cahill"'
Autor:
Ryan J Malonis, George I Georgiev, Denise Haslwanter, Laura A VanBlargan, Georgia Fallon, Olivia Vergnolle, Sean M Cahill, Richard Harris, David Cowburn, Kartik Chandran, Michael S Diamond, Jonathan R Lai
Publikováno v:
PLoS Pathogens, Vol 18, Iss 6, p e1010573 (2022)
Powassan virus (POWV) is an emerging tick borne flavivirus (TBFV) that causes severe neuroinvasive disease. Currently, there are no approved treatments or vaccines to combat POWV infection. Here, we generated and characterized a nanoparticle immunoge
Externí odkaz:
https://doaj.org/article/cd4057e1ec1c4b8f86ac31bc376dde61
Autor:
Yacoba V. T. Minnow, Kajitha Suthagar, Keith Clinch, Rodrigo G. Ducati, Agnidipta Ghosh, Joshua N. Buckler, Rajesh K. Harijan, Sean M. Cahill, Peter C. Tyler, Vern L. Schramm
Publikováno v:
ACS Chemical Biology. 17:3407-3419
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::82c67dd5edbd1f0cfc6bc502e7fce05a
https://doi.org/10.1021/acschembio.2c00546
https://doi.org/10.1021/acschembio.2c00546
Publikováno v:
ACS Chemical Biology. 17:2507-2518
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef83f3971f24193bfb9fdf227e269bb4
https://doi.org/10.1021/acschembio.2c00408
https://doi.org/10.1021/acschembio.2c00408
Autor:
Sean M. Cahill, Courtney N. Niland, Agnidipta Ghosh, Nishant M. Karadkhelkar, Vern L. Schramm
Publikováno v:
J Am Chem Soc
Human methionine adenosyltransferase MAT2A provides S-adenosyl-l-methionine (AdoMet) for methyl-transfer reactions. Epigenetic methylations influence expression patterns in development and in cancer. Transition-state analysis and kinetic studies have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7733a0a7bf0eb56842029b613c7d8cd0
https://doi.org/10.1021/jacs.1c09328
https://doi.org/10.1021/jacs.1c09328
Autor:
Ganjam V. Kalpana, P. Rajesh Kumar, Steven C. Almo, Liming Qiu, Savita Bhutoria, Seetharama A. Acharya, Xiaoqin Zou, Sheeba Mathew, Lucas J. Adams, Richard Harris, Minh B. Nguyen, Updesh Dixit, Alasdair C. Steven, Xuhong Wu, Michael Brenowitz, Menachem Spira, Sean M. Cahill, Rajiv Pathak, Mark E. Girvin, David Cowburn
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
INI1/SMARCB1 binds to HIV-1 integrase (IN) through its Rpt1 domain and exhibits multifaceted role in HIV-1 replication. Determining the NMR structure of INI1-Rpt1 and modeling its interaction with the IN-C-terminal domain (IN-CTD) reveal that INI1-Rp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e55ea014d49329f1c6270672c54680ce
https://doi.org/10.1038/s41467-021-22733-9
https://doi.org/10.1038/s41467-021-22733-9
Publikováno v:
Biochemistry
S-Adenosyl-l-methionine (AdoMet) is synthesized by the MAT2A isozyme of methionine adenosyltransferase in most human tissues and in cancers. Its contribution to epigenetic control has made it a target for anticancer intervention. A recent kinetic iso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f1d63eab2fa9650ef88a974c5b315010
https://pubmed.ncbi.nlm.nih.gov/33656855
https://pubmed.ncbi.nlm.nih.gov/33656855
Autor:
George I. Georgiev, Ryan J. Malonis, Ariel S. Wirchnianski, Alex W. Wessel, Helen S. Jung, Sean M. Cahill, Elisabeth K. Nyakatura, Olivia Vergnolle, Kimberly A. Dowd, David Cowburn, Theodore C. Pierson, Michael S. Diamond, Jonathan R. Lai
Publikováno v:
Cell Chem Biol
Zika virus (ZIKV) is a flavivirus that can cause severe disease, but there are no approved treatments or vaccines. A complication for flavivirus vaccine development is the potential of immunogens to enhance infection via antibody-dependent enhancemen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::974ff4d74cb5bb818376d8ddbcee4e36
https://doi.org/10.1016/j.chembiol.2022.02.004
https://doi.org/10.1016/j.chembiol.2022.02.004
Autor:
Steven C. Almo, Kartik Chandran, Craig E. Cameron, Sean M. Cahill, Natalya G. Dulyaninova, J. Love, Jamie J. Arnold, Joyce Jose, Scott J. Garforth, Anne R. Bresnick, Quan Du, Tyler L. Grove, Rohit K. Jangra, Anthony S. Gizzi
Publikováno v:
Nature
Viral infections continue to represent major challenges to public health, and an enhanced mechanistic understanding of the processes that contribute to viral life cycles is necessary for the development of new therapeutic strategies1. Viperin, a memb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ae38d63251e53d7ac4c5f0e10219ffb
https://doi.org/10.1038/s41586-018-0238-4
https://doi.org/10.1038/s41586-018-0238-4
Autor:
Jerome M. Karp, Sean M. Cahill, Michael Brenowitz, Takashi Onikubo, Christopher D. Warren, David Shechter, Mark E. Girvin, David Cowburn, Tsutomu Matsui
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Nucleoplasmin (Npm) is a highly conserved histone chaperone responsible for the maternal storage and zygotic release of histones H2A/H2B. Npm contains a pentameric N-terminal core domain and an intrinsically disordered C-terminal tail domain. Though
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdbc459a9e365a5435531f632ae9325c
http://link.springer.com/article/10.1038/s41467-017-02308-3
http://link.springer.com/article/10.1038/s41467-017-02308-3
Autor:
Anthony S. Gizzi, Tyler L. Grove, Jamie J. Arnold, Joyce Jose, Rohit K. Jangra, Scott J. Garforth, Quan Du, Sean M. Cahill, Natalya G. Dulyaninova, James D. Love, Kartik Chandran, Anne R. Bresnick, Craig E. Cameron, Steven C. Almo
Publikováno v:
Nature. 583:E15-E15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dffa5948f29980814384fa3f38c8b1b1
https://doi.org/10.1038/s41586-020-2322-9
https://doi.org/10.1038/s41586-020-2322-9