Zobrazeno 1 - 10
of 164
pro vyhledávání: '"Sean M Wu"'
Autor:
Francisco X Galdos, Carissa Lee, Soah Lee, Sharon Paige, William Goodyer, Sidra Xu, Tahmina Samad, Gabriela V Escobar, Adrija Darsha, Aimee Beck, Rasmus O Bak, Matthew H Porteus, Sean M Wu
Publikováno v:
eLife, Vol 12 (2023)
During mammalian development, the left and right ventricles arise from early populations of cardiac progenitors known as the first and second heart fields, respectively. While these populations have been extensively studied in non-human model systems
Externí odkaz:
https://doaj.org/article/7b95553730564799a2f6d70a7dbf76c3
Autor:
Laura Tarnawski, Xiaojie Xian, Gustavo Monnerat, Iain C Macaulay, Daniela Malan, Andrew Borgman, Sean M Wu, Bernd K Fleischmann, Stefan Jovinge
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135880 (2015)
In contrast to mature cardiomyocytes which have limited regenerative capacity, pluripotent stem cells represent a promising source for the generation of new cardiomyocytes. The tendency of pluripotent stem cells to form teratomas and the heterogeneit
Externí odkaz:
https://doaj.org/article/7f544021333c48dd93c441c2c22e1878
Autor:
Stefanie A Doppler, Astrid Werner, Melanie Barz, Harald Lahm, Marcus-André Deutsch, Martina Dreßen, Matthias Schiemann, Bernhard Voss, Serge Gregoire, Rajarajan Kuppusamy, Sean M Wu, Rüdiger Lange, Markus Krane
Publikováno v:
PLoS ONE, Vol 9, Iss 12, p e113775 (2014)
Vertebrate heart development is strictly regulated by temporal and spatial expression of growth and transcription factors (TFs). We analyzed nine TFs, selected by in silico analysis of an Nkx2.5 enhancer, for their ability to transactivate the respec
Externí odkaz:
https://doaj.org/article/6df604b6caeb4edca43566298b87fbef
Autor:
Francisco X. Galdos, Sidra Xu, William R. Goodyer, Lauren Duan, Yuhsin V. Huang, Soah Lee, Han Zhu, Carissa Lee, Nicholas Wei, Daniel Lee, Sean M. Wu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
A major informatic challenge in single cell RNA-sequencing analysis is the precise annotation of datasets where cells exhibit complex multilayered identities or transitory states. Here the authors present devCellPy, a Python-based package that enable
Externí odkaz:
https://doaj.org/article/3f3de35dacac4204a087d5bb4feffee4
Autor:
Yuhsin Vivian Huang, Sarah Waliany, Daniel Lee, Francisco X. Galdos, Ronald M. Witteles, Joel W. Neal, Alice C. Fan, Holden T. Maecker, Patricia K. Nguyen, Sean M. Wu, Han Zhu
Publikováno v:
JACC: CardioOncology. 4:629-634
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d88e6dde6b4c76c835cefa545c97691
https://doi.org/10.1016/j.jaccao.2022.08.012
https://doi.org/10.1016/j.jaccao.2022.08.012
Autor:
Andrew T. Nguyen, Gerald J. Berry, Ronald M. Witteles, Dung T. Le, Sean M. Wu, George A. Fisher, Han Zhu
Publikováno v:
JACC: CardioOncology. 4:727-730
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c59f69a2159dc9d4d4b7878a7750f1e6
https://doi.org/10.1016/j.jaccao.2022.04.007
https://doi.org/10.1016/j.jaccao.2022.04.007
Autor:
Zhiyun Yu, Xin Zhou, Ziyi Liu, Victor Pastrana-Gomez, Yu Liu, Minzhe Guo, Lei Tian, Timothy J. Nelson, Nian Wang, Seema Mital, David Chitayat, Joseph C. Wu, Marlene Rabinovitch, Sean M. Wu, Michael P. Snyder, Yifei Miao, Mingxia Gu
Publikováno v:
Circulation research. 131(3)
Hypoplastic left heart syndrome (HLHS) is a severe form of single ventricle congenital heart disease characterized by an underdevelopment of the left ventricle. Early serial postmortem examinations revealed high rate of coronary artery abnormalities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a86fa4f2807a9f0ec61948adc6f4324
https://pubmed.ncbi.nlm.nih.gov/35762338
https://pubmed.ncbi.nlm.nih.gov/35762338
Autor:
Han Zhu, Francisco X. Galdos, Daniel Lee, Sarah Waliany, Yuhsin Vivian Huang, Julia Ryan, Katherine Dang, Joel W. Neal, Heather A. Wakelee, Sunil A. Reddy, Sandy Srinivas, Lih-Ling Lin, Ronald M. Witteles, Holden T. Maecker, Mark M. Davis, Patricia K. Nguyen, Sean M. Wu
Publikováno v:
Circulation. 146:316-335
Background: Immune checkpoint inhibitors (ICIs) are monoclonal antibodies used to activate the immune system against tumor cells. Despite therapeutic benefits, ICIs have the potential to cause immune-related adverse events such as myocarditis, a rare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1164535144e581c27c0a8ed42140cfd5
https://doi.org/10.1161/circulationaha.121.056730
https://doi.org/10.1161/circulationaha.121.056730
Immune checkpoint inhibitor cardiotoxicity: Breaking barriers in the cardiovascular immune landscape
Publikováno v:
Journal of Molecular and Cellular Cardiology. 160:121-127
Immune checkpoint inhibitors (ICI) have changed the landscape of cancer therapy, but their use carries a high risk of cardiac immune related adverse events (iRAEs). With the expanding utilization of ICI therapy, there is a growing need to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b800a6d0a6e0752c2c43ccb39b305347
https://doi.org/10.1016/j.yjmcc.2021.07.006
https://doi.org/10.1016/j.yjmcc.2021.07.006
Autor:
Tahmina Samad, Sean M. Wu
Publikováno v:
Semin Cell Dev Biol
The development of single cell RNA sequencing technologies has accelerated the ability of scientists to understand healthy and disease states of the cardiovascular system. Congenital heart defects occur in approximately 40,000 births each year and 1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa2f7eecb2a0e02ca4e2f8ac8b50156c
https://doi.org/10.1016/j.semcdb.2021.04.023
https://doi.org/10.1016/j.semcdb.2021.04.023