Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sean M West"'
Autor:
Alexandra Bezler, Fabian Braukmann, Sean M West, Arthur Duplan, Raffaella Conconi, Frédéric Schütz, Pierre Gönczy, Fabio Piano, Kristin Gunsalus, Eric A Miska, Laurent Keller
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007905 (2019)
RNA interference (RNAi) related pathways are essential for germline development and fertility in metazoa and can contribute to inter- and trans-generational inheritance. In the nematode Caenorhabditis elegans, environmental double-stranded RNA provid
Externí odkaz:
https://doaj.org/article/6fc5c70670af45709b9f653aff62b037
Autor:
Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanom
Externí odkaz:
https://doaj.org/article/00341078d5a94f57ba93043742d00efb
Autor:
Jason M. Hogan, Peter S. Lee, Susan C. Wong, Sean M. West, Winse H. Morishige, Christine Bee, Gamze Camdere Tapia, Arvind Rajpal, Pavel Strop, Gavin Dollinger
Publikováno v:
Analytical Chemistry. 95:3922-3931
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e0c6823719cc6932032d8c81e4b705
https://doi.org/10.1021/acs.analchem.2c03091
https://doi.org/10.1021/acs.analchem.2c03091
Autor:
Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provid
Externí odkaz:
https://doaj.org/article/f8bc83b729b6455e90c4ca6aa57051c9
Autor:
Sayumi Yamazoe, Srikanth Kotapati, Jason M. Hogan, Sean M. West, Xiaodi A. Deng, SJ Diong, Jaren Arbanas, Thien Anh Nguyen, Aarti Jashnani, Diksha Gupta, Arvind Rajpal, Gavin Dollinger, Pavel Strop
Publikováno v:
Bioconjugate Chemistry. 33:576-585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbd22a83c075f443988ba96a030d22a
https://doi.org/10.1021/acs.bioconjchem.1c00572
https://doi.org/10.1021/acs.bioconjchem.1c00572
Autor:
Arvind Rajpal, Mary Huber, Patrick G. Holder, Xiaodi A Deng, Jason M. Hogan, Sanjeev Gangwar, Gavin Dollinger, Xiang Shao, Sayumi Yamazoe, Vandana Lamba, Chetana Rao, Srikanth Kotapati, Pavel Strop, Sean M. West, Cong Qiang
Publikováno v:
Bioconjugate Chemistry. 31:1199-1208
Antibody-drug conjugates (ADCs) are a therapeutic modality that traditionally enable the targeted delivery of highly potent cytotoxic agents to specific cells such as tumor cells. More recently, antibodies have been used to deliver molecules such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc5ba6b4cb00dddcb04ce1874f50359
https://doi.org/10.1021/acs.bioconjchem.0c00146
https://doi.org/10.1021/acs.bioconjchem.0c00146
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific reports. 12(1)
T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited to xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375164f1029903cd33f957b64a8de04e
https://pubmed.ncbi.nlm.nih.gov/35241687
https://pubmed.ncbi.nlm.nih.gov/35241687
Autor:
Pavel Strop, Feng Wang, Donata David-brown, Bryant Chau, Christine Bee, Jordan C Tsai, Alexander T. Kozhich, Arvind Rajpal, Jason M. Hogan, Sean M. West, Thomas Cayton, Jia Dong, Tim Sproul, Winse Morishige, Matthew L. Wheeler, Jonathan H Davis, Chengyue Zhang, Gavin Dollinger
Publikováno v:
mAbs
article-version (VoR) Version of Record
article-version (VoR) Version of Record
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b89c55454f02ef3a8f9046a38a960b5f
https://pubmed.ncbi.nlm.nih.gov/34225582
https://pubmed.ncbi.nlm.nih.gov/34225582
Autor:
M. Gutwein, Fabio Piano, David Aristizábal-Corrales, D. Mecenas, Sean M. West, Kristin C. Gunsalus
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Genome Biology
Genome Biology
Background The 3′ untranslated regions (UTRs) of mRNAs play a major role in post-transcriptional regulation of gene expression. Selection of transcript cleavage and polyadenylation sites is a dynamic process that produces multiple transcript isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca54655025eed2547acf0368557d1647
http://link.springer.com/article/10.1186/s13059-017-1369-x
http://link.springer.com/article/10.1186/s13059-017-1369-x
Autor:
Sean M. West, Xiaodi A Deng
Publikováno v:
Exp Biol Med (Maywood)
With the emergence of immuno-oncology, new therapeutic agents that modulate immune activation and regulation are being used to treat cancer patients with durable response. It is well known that following T-cell receptor (TCR) activation, many co-rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f64ed41f8129061f61f418677dd9ea
https://pubmed.ncbi.nlm.nih.gov/31208204
https://pubmed.ncbi.nlm.nih.gov/31208204