Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Sean M West"'
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited t
Externí odkaz:
https://doaj.org/article/3a2265c1ac814c838bd81c163786a89d
Autor:
Feng Wang, Bryant Chau, Sean M. West, Christopher R. Kimberlin, Fei Cao, Flavio Schwarz, Barbara Aguilar, Minhua Han, Winse Morishige, Christine Bee, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) regulate immune cell activities, including anti-tumor immune responses. Structures and visualization of human and mouse GITR–GITRL complexes offer
Externí odkaz:
https://doaj.org/article/339a2bcd2cae4b929cc7ae8a3d566f01
Autor:
Ornella Pagliano, Robert M. Morrison, Joe-Marc Chauvin, Hridesh Banerjee, Diwakar Davar, Quanquan Ding, Tokiyoshi Tanegashima, Wentao Gao, Saranya R. Chakka, Richelle DeBlasio, Ava Lowin, Kevin Kara, Mignane Ka, Bochra Zidi, Rada Amin, Itay Raphael, Shuowen Zhang, Simon C. Watkins, Cindy Sander, John M. Kirkwood, Marcus Bosenberg, Ana C. Anderson, Vijay K. Kuchroo, Lawrence P. Kane, Alan J. Korman, Arvind Rajpal, Sean M. West, Minhua Han, Christine Bee, Xiaodi Deng, Xiao Min Schebye, Pavel Strop, Hassane M. Zarour
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 9 (2022)
T cell immunoglobulin mucin domain-containing protein 3 (Tim-3) negatively regulates innate and adaptive immunity in cancer. To identify the mechanisms of Tim-3 in cancer immunity, we evaluated the effects of Tim-3 blockade in human and mouse melanom
Externí odkaz:
https://doaj.org/article/00341078d5a94f57ba93043742d00efb
Autor:
Jason M. Hogan, Peter S. Lee, Susan C. Wong, Sean M. West, Winse H. Morishige, Christine Bee, Gamze Camdere Tapia, Arvind Rajpal, Pavel Strop, Gavin Dollinger
Publikováno v:
Analytical Chemistry. 95:3922-3931
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0e0c6823719cc6932032d8c81e4b705
https://doi.org/10.1021/acs.analchem.2c03091
https://doi.org/10.1021/acs.analchem.2c03091
Autor:
Feng Wang, Jordan C. Tsai, Jonathan H. Davis, Bryant Chau, Jia Dong, Sean M. West, Jason M. Hogan, Matthew L. Wheeler, Christine Bee, Winse Morishige, Thomas Cayton, Donata David-brown, Chengyue Zhang, Alexander Kozhich, Tim Sproul, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Publikováno v:
mAbs, Vol 12, Iss 1 (2020)
The development of antibody therapeutics relies on animal models that accurately recapitulate disease biology. Syngeneic mouse models are increasingly used with new molecules to capture the biology of complex cancers and disease states, and to provid
Externí odkaz:
https://doaj.org/article/f8bc83b729b6455e90c4ca6aa57051c9
Autor:
Sean M. West, Desirea Mecenas, Michelle Gutwein, David Aristizábal-Corrales, Fabio Piano, Kristin C. Gunsalus
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-19 (2018)
Abstract Background The 3′ untranslated regions (UTRs) of mRNAs play a major role in post-transcriptional regulation of gene expression. Selection of transcript cleavage and polyadenylation sites is a dynamic process that produces multiple transcri
Externí odkaz:
https://doaj.org/article/6eba10788dd54b8d92763ed623d61c02
Autor:
Alexandra Bezler, Fabian Braukmann, Sean M West, Arthur Duplan, Raffaella Conconi, Frédéric Schütz, Pierre Gönczy, Fabio Piano, Kristin Gunsalus, Eric A Miska, Laurent Keller
Publikováno v:
PLoS Genetics, Vol 15, Iss 2, p e1007905 (2019)
RNA interference (RNAi) related pathways are essential for germline development and fertility in metazoa and can contribute to inter- and trans-generational inheritance. In the nematode Caenorhabditis elegans, environmental double-stranded RNA provid
Externí odkaz:
https://doaj.org/article/6fc5c70670af45709b9f653aff62b037
Autor:
Sayumi Yamazoe, Srikanth Kotapati, Jason M. Hogan, Sean M. West, Xiaodi A. Deng, SJ Diong, Jaren Arbanas, Thien Anh Nguyen, Aarti Jashnani, Diksha Gupta, Arvind Rajpal, Gavin Dollinger, Pavel Strop
Publikováno v:
Bioconjugate Chemistry. 33:576-585
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fbd22a83c075f443988ba96a030d22a
https://doi.org/10.1021/acs.bioconjchem.1c00572
https://doi.org/10.1021/acs.bioconjchem.1c00572
Autor:
Arvind Rajpal, Mary Huber, Patrick G. Holder, Xiaodi A Deng, Jason M. Hogan, Sanjeev Gangwar, Gavin Dollinger, Xiang Shao, Sayumi Yamazoe, Vandana Lamba, Chetana Rao, Srikanth Kotapati, Pavel Strop, Sean M. West, Cong Qiang
Publikováno v:
Bioconjugate Chemistry. 31:1199-1208
Antibody-drug conjugates (ADCs) are a therapeutic modality that traditionally enable the targeted delivery of highly potent cytotoxic agents to specific cells such as tumor cells. More recently, antibodies have been used to deliver molecules such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc5ba6b4cb00dddcb04ce1874f50359
https://doi.org/10.1021/acs.bioconjchem.0c00146
https://doi.org/10.1021/acs.bioconjchem.0c00146
Autor:
Julie A. Zorn, Matthew L. Wheeler, Ralston M. Barnes, Jim Kaberna, Winse Morishige, Marek Harris, Richard Y.-C. Huang, Jack Lohre, Yu Ching Chang, Bryant Chau, Kathleen Powers, Ian Schindler, Naveen Neradugomma, Winston Thomas, Xiaoyun Liao, Yinhan Zhou, Sean M. West, Feng Wang, Srikanth Kotapati, Guodong Chen, Sayumi Yamazoe, Anastasia Kosenko, Gavin Dollinger, Tim Sproul, Arvind Rajpal, Pavel Strop
Publikováno v:
Scientific reports. 12(1)
T-cell engagers (TCEs) are a growing class of biotherapeutics being investigated in the clinic for treatment of a variety of hematological and solid tumor indications. However, preclinical evaluation of TCEs in vivo has been mostly limited to xenogra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375164f1029903cd33f957b64a8de04e
https://pubmed.ncbi.nlm.nih.gov/35241687
https://pubmed.ncbi.nlm.nih.gov/35241687