Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Sean M Cullen"'
Autor:
Chongyuan Luo, Qian Yi Lee, Orly Wapinski, Rosa Castanon, Joseph R Nery, Moritz Mall, Michael S Kareta, Sean M Cullen, Margaret A Goodell, Howard Y Chang, Marius Wernig, Joseph R Ecker
Publikováno v:
eLife, Vol 8 (2019)
Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. Here, we characterized global epigenomic changes during the direct reprogramming of mouse fibroblasts to neurons using whole-genome base-r
Externí odkaz:
https://doaj.org/article/9ddb88e6e2a54fc28cfcbc1f3cab0113
Autor:
Raghav Ramabadran, Jarey H. Wang, Jaime M. Reyes, Anna G. Guzman, Sinjini Gupta, Carina Rosas, Lorenzo Brunetti, Michael C. Gundry, Ayala Tovy, Hali Long, Tianpeng Gu, Sean M. Cullen, Siddhartha Tyagi, Danielle Rux, Jean J. Kim, Steven M. Kornblau, Michael Kyba, Fabio Stossi, Rachel E. Rau, Koichi Takahashi, Thomas F. Westbrook, Margaret A. Goodell
Publikováno v:
Nature Cell Biology. 25:528-539
Publikováno v:
Biology of Reproduction. 105:747-760
It is well established that environmental exposures can modify the profile of heritable factors in an individual's germ cells, ultimately affecting the inheritance of phenotypes in descendants. Similar to exposures, an ancestor's genotype can also af
Publikováno v:
Pediatrics. 150
OBJECTIVES Liquid medication dosing errors are common in pediatrics. Our outpatient clinic identified gaps in caregiver education based on a 2015 American Academy of Pediatrics policy statement on prescribing liquid medications. This quality improvem
Autor:
Anna Guzman, Margaret A. Goodell, Wei Li, Jianjun Shen, Min Luo, Taiping Chen, Jianzhong Su, Deqiang Sun, Yun Huang, Danielle Rux, Sean M Cullen, Tianpeng Gu, Marcos R. Estecio, Mira Jeong, Michael Kyba, Jia Jia Chen, Swanand Hardikar, Xueqiu Lin, Lei Stanley Qi, Minjung Lee
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Genome Biology
Genome Biology
Background DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be further oxidi
Publikováno v:
Biology of Reproduction. 105:1365-1365
Autor:
Sean M Cullen, Howard Y. Chang, Chongyuan Luo, Margaret A. Goodell, Qian Yi Lee, Michael S. Kareta, Orly L. Wapinski, Joseph R. Ecker, Marius Wernig, Moritz Mall, Rosa Castanon, Joseph R. Nery
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5cc725fc20f68d12dfd4da343d7c596
https://doi.org/10.7554/elife.40197.020
https://doi.org/10.7554/elife.40197.020
Autor:
Chongyuan Luo, Marius Wernig, Joseph R. Ecker, Margaret A. Goodell, Sean M Cullen, Howard Y. Chang, Qian Yi Lee, Orly L. Wapinski, Rosa Castanon, Joseph R. Nery
Direct reprogramming of fibroblasts to neurons induces widespread cellular and transcriptional reconfiguration. In this study, we characterized global epigenomic changes during direct reprogramming using whole-genome base-resolution DNA methylome (mC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa1eb00dea277bbc81bd43775f854c57
https://doi.org/10.1101/371427
https://doi.org/10.1101/371427
Autor:
Margaret A. Goodell, Mira Jeong, Deqiang Sun, Zheng Xia, Benjamin Rodriguez, Allison Mayle, Min Luo, Liubin Yang, Grant A. Challen, Yayun Zheng, Hamza Celik, Jonathan S. Berg, Gretchen J. Darlington, Cates Mallaney, Sean M Cullen, Wei Li
Publikováno v:
Cell Stem Cell. 15(3):350-364
Hematopoietic stem cells (HSCs) are the precursors of the hematopoietic system responsible for the lifelong production of blood and bone marrow. Given the emerging importance of epigenetic regulation in HSC fate decisions and malignant transformation
Autor:
Andrew A. Pieper, Sébastien Vigneau, Latisha McDaniel, Joanna L. Jankowsky, Min Fang, Diana C. Parra, Sybille D. Reichardt, Irwin D. Bernstein, Stephanie Tran, Daniel J. Brat, Yue Yang, Jeffrey L. Neul, David A. Flowers, Marisa S. Bartolomei, Margaret A. Goodell, Teng-Wei Huang, Smitha Sripathy, Peter Huppke, Julia Kozlitina, Jeremiah K. Britt, Uyen Lao, Jutta Gärtner, C. Dirk Keene, Ruth Starwalt, Sean M Cullen, Keith R. Loeb, Antonio Bedalov, Pin Xu, Whitney Knobbe, Héctor De Jesús-Cortés, Benjamin Newcomb, Christopher S. Ward, Jan Eike Wegener, Holger M. Reichardt, Jieqi Wang, Vid Leko, Michael J. Yetman, Nikolas L. Jorstad, Lena Glaskova, Cynthia Nourigat
arising from N. C. Derecki et al. , 105–109 (2012); doi:10.1038/nature10907 Rett syndrome is a severe neurodevelopmental disorder caused by mutations in the X chromosomal gene MECP2 (ref. 1), and its treatment so far is symptomatic. Mecp2 disruptio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47cc568ddc5cea00abaf6ba61319658a
https://europepmc.org/articles/PMC4684952/
https://europepmc.org/articles/PMC4684952/