Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sean M Carney"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Nonhomologous end joining (NHEJ), the primary pathway of vertebrate DNA double-strand-break (DSB) repair, directly re-ligates broken DNA ends. Damaged DSB ends that cannot be immediately re-ligated are modified by NHEJ processing enzymes, in
Externí odkaz:
https://doaj.org/article/7f144421046948c4965c6d45b0ca0c4a
Autor:
Sean M Carney, Andrew T Moreno, Sadie C Piatt, Metztli Cisneros-Aguirre, Felicia Wednesday Lopezcolorado, Jeremy M Stark, Joseph J Loparo
Publikováno v:
eLife, Vol 9 (2020)
Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks in vertebrates. During NHEJ DNA ends are held together by a multi-protein synaptic complex until they are ligated. Here, we use Xenopus laevis egg extr
Externí odkaz:
https://doaj.org/article/a69dfe15dfac41d0bcf7b6e555d1a2a5
SUMMARYNonhomologous end joining (NHEJ) is the primary pathway of vertebrate DNA double-strand-break repair. NHEJ polymerases and nucleases can modify DNA ends to render them compatible for ligation, but these enzymes are usually deployed only when n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d54390d31072f7dde46fb593d099fcd
https://doi.org/10.1101/2022.10.26.513880
https://doi.org/10.1101/2022.10.26.513880
Autor:
Felicia Wednesday Lopezcolorado, Joseph J. Loparo, Sean M. Carney, Metztli Cisneros-Aguirre, Sadie C. Piatt, Jeremy M. Stark, Andrew T. Moreno
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Non-homologous end joining (NHEJ) is the predominant pathway that repairs DNA double-strand breaks in vertebrates. During NHEJ DNA ends are held together by a multi-protein synaptic complex until they are ligated. Here, we use Xenopus laevis egg extr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::963aadcff0373bd86bc42a6ec4ff4840
https://doi.org/10.7554/elife.61920
https://doi.org/10.7554/elife.61920
Autor:
Felicia Wednesday Lopezcolorado, Sadie C. Piatt, Joseph J. Loparo, Andrew T. Moreno, Jeremy M. Stark, Metztli Cisneros-Aguirre, Sean M. Carney
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3215bd91a910fd92fe14a8033f724f5
https://doi.org/10.7554/elife.61920.sa2
https://doi.org/10.7554/elife.61920.sa2
Publikováno v:
Nature structural & molecular biology
Non-homologous end joining (NHEJ) is the primary pathway of DNA double-strand break repair in vertebrate cells, yet it remains unclear how NHEJ factors assemble a synaptic complex that bridges DNA ends. To address the role of XRCC4-like factor (XLF)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b25d0877524ff1e4db2aeca82eedda7
http://europepmc.org/articles/PMC6128732
http://europepmc.org/articles/PMC6128732
Publikováno v:
Journal of Biological Chemistry. 292:19001-19012
Replicative hexameric helicases are thought to unwind duplex DNA by steric exclusion (SE) where one DNA strand is encircled by the hexamer and the other is excluded from the central channel. However, interactions with the excluded strand on the exter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e70de3897fdf9ec2929d02bdc280127
https://doi.org/10.1074/jbc.m117.814178
https://doi.org/10.1074/jbc.m117.814178
Publikováno v:
Biophysical Journal. 118:71a-72a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19856bcfd6307f364c162f7b478dff65
https://doi.org/10.1016/j.bpj.2019.11.566
https://doi.org/10.1016/j.bpj.2019.11.566
Autor:
Michael A. Trakselis, Sean M. Carney
Publikováno v:
Methods. 108:79-91
Helicases are proposed to unwind dsDNA primarily by translocating on one strand to sterically exclude and separate the two strands. Hexameric helicases in particular have been shown to encircle one strand while physically excluding the other strand.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8293f037c28a4d3a55b622a55f2901bd
https://doi.org/10.1016/j.ymeth.2016.04.008
https://doi.org/10.1016/j.ymeth.2016.04.008
Autor:
Sean M. Carney, Joshua A. Sommers, Elena Yakubovskaya, Sanjay Kumar Bharti, Robert M. Brosh, Jack D. Crouch, Michael A. Trakselis, Irfan Khan, Miguel Garcia-Diaz
Publikováno v:
Journal of Biological Chemistry. 291:14324-14339
Mutations in the c10orf2 gene encoding the human mitochondrial DNA replicative helicase Twinkle are linked to several rare genetic diseases characterized by mitochondrial defects. In this study, we have examined the catalytic activity of Twinkle heli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d889612a266f0ce0c3dc819f00f74c
https://doi.org/10.1074/jbc.m115.712026
https://doi.org/10.1074/jbc.m115.712026