Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Sean M Bell"'
Autor:
Sean M Bell, Dan J Wendt, Yanhong Zhang, Timothy W Taylor, Shinong Long, Laurie Tsuruda, Bin Zhao, Phillip Laipis, Paul A Fitzpatrick
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173269 (2017)
Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is not
Externí odkaz:
https://doaj.org/article/ce5628e0933647178d98a97a916845ad
Autor:
Florence Lorget, Sean M. Bell, Mika Aoyagi-Scharber, Sianna Castillo, William R. Wilcox, Pavel Krejci, Melita Dvorak-Ewell, David L. Rimoin, Jeff Peng, Charles A. O’Neill, Stuart Bunting, Daniel J. Wendt, Sherry Bullens
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 353:132-149
Achondroplasia (ACH), the most common form of human dwarfism, is caused by an activating autosomal dominant mutation in the fibroblast growth factor receptor-3 gene. Genetic overexpression of C-type natriuretic peptide (CNP), a positive regulator of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::754c5c256ff0cb2abb4eb6148f359496
https://doi.org/10.1124/jpet.114.218560
https://doi.org/10.1124/jpet.114.218560
Autor:
Chuck Hague, Amanda R. Lee, Geoffrey Y. Berguig, Jonathan H. LeBowitz, Sean M. Bell, Donald S. Mackenzie, Gouri Yogalingam, Travis J. Maures, Terri Christianson, Agnes Rafalko, Heather Prill
Neutrophil myeloperoxidase (MPO) catalyzes the H2O2-dependent oxidation of chloride anion to generate hypochlorous acid, a potent antimicrobial agent. Besides its well defined role in innate immunity, aberrant degranulation of neutrophils in several
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e94f5b7599bb670e8911abe281edae9
https://europepmc.org/articles/PMC5354499/
https://europepmc.org/articles/PMC5354499/
Autor:
Timothy W. Taylor, Zhang Yanhong, Laurie S. Tsuruda, Dan J Wendt, Phillip Laipis, Bin Zhao, Shinong Long, Paul A. Fitzpatrick, Sean M. Bell
Publikováno v:
PLoS ONE, Vol 12, Iss 3, p e0173269 (2017)
PLoS ONE
PLoS ONE
Phenylketonuria (PKU) is a genetic metabolic disease in which the decrease or loss of phenylalanine hydroxylase (PAH) activity results in elevated, neurotoxic levels of phenylalanine (Phe). Due to many obstacles, PAH enzyme replacement therapy is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46943a7882979355ad76283bb5b5d451
http://europepmc.org/articles/PMC5345807?pdf=render
http://europepmc.org/articles/PMC5345807?pdf=render
Autor:
Francesca Pierigè, Paul A. Fitzpatrick, Tiziana Pascucci, Luigia Rossi, Barbara Canonico, Sean M. Bell, Vincenzo Leuzzi, Claudia Carducci, Mauro Magnani, Claudia Gabucci
Publikováno v:
Journal of Controlled Release. 194:37-44
Phenylketonuria (PKU) is an autosomal recessive genetic disease caused by defects in the phenylalanine hydroxylase gene. Preclinical and clinical investigations suggest that phenylalanine ammonia lyase (PAL) could be an effective alternative for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::153a475f303db6fc447bd9682ae33680
https://doi.org/10.1016/j.jconrel.2014.08.012
https://doi.org/10.1016/j.jconrel.2014.08.012
Autor:
Sean M. Bell, Linda M. Vind, Amy D. Skora, Michael C. Fiore, Robert Adsit, Michelle Simerson, Bradley M. Fox, Carolyn Ogland, Timothy B. Baker, Thanos Tsiolis
Publikováno v:
Translational Behavioral Medicine. 4:324-332
Few smokers receive evidence-based tobacco treatment during healthcare visits. Electronic health records (EHRs) present an opportunity to efficiently identify and refer smokers to state tobacco quitlines. The purpose of this case study is to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e448cd0a3f96e6b7ee5716e502823676
https://doi.org/10.1007/s13142-014-0259-y
https://doi.org/10.1007/s13142-014-0259-y
Autor:
Jeffrey F. Lemontt, Laurie Tsuruda, Raymond C. Stevens, Christineh N. Sarkissian, Bin Zhao, Amy Lambert, Carroll Henschell, Marilyse Charbonneau, Charles R. Scriver, Paul F. Fitzpatrick, Michael Vellard, Sean M. Bell, Alejandra Gámez, Lin Wang
Publikováno v:
Proceedings of the National Academy of Sciences. 105:20894-20899
Phenylketonuria (PKU) is a metabolic disorder, in which loss of phenylalanine hydroxylase activity results in neurotoxic levels of phenylalanine. We used the Pah enu2/enu2 PKU mouse model in short- and long-term studies of enzyme substitution therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57db3d63a1f1f25817739af87e5dfebd
https://doi.org/10.1073/pnas.0808421105
https://doi.org/10.1073/pnas.0808421105
Autor:
Miyuki Kawano, Alexandra Charruyer, Bruce A. Macher, Sean M. Bell, Kentaro Hanada, Ten-Yang Yen, Yoshikazu Uchida, Keigo Kumagai, Walter M. Holleran, Sounthala Douangpanya
Publikováno v:
Journal of Biological Chemistry. 283:16682-16692
Increased cellular ceramide accounts in part for UVB irradiation-induced apoptosis in cultured human keratinocytes with concurrent increased glucosylceramide but not sphingomyelin generation in these cells. Given that conversion of ceramide to non-ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7671107b4875aec5a494203d01f9a65b
https://doi.org/10.1074/jbc.m800799200
https://doi.org/10.1074/jbc.m800799200
Autor:
Mason R. Mackey, Marsha L. Crochiere, Sean M. Bell, Andrejs M. Krumins, Roger K. Sunahara, Susan S. Taylor, Guy Perkins, Lin Wang, Mark H. Ellisman
Publikováno v:
Proceedings of the National Academy of Sciences. 98:3220-3225
Differential compartmentalization of signaling molecules in cells and tissues is being recognized as an important mechanism for regulating the specificity of signal transduction pathways. A kinase anchoring proteins (AKAPs) direct the subcellular loc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07d1288605364d7014a8d4c15039f63
https://doi.org/10.1073/pnas.051633398
https://doi.org/10.1073/pnas.051633398
Autor:
Gouri Yogalingam, Sean M. Bell, Jonathan H. LeBowitz, Travis J. Maures, Amanda R. Lee, Terri Christianson, Donnie Mackenzie, Agnes Rafalko, Heather Prill
Publikováno v:
Molecular Genetics and Metabolism. 117:S122
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64122d460efac37ed5fe8a2ac8e6efc4
https://doi.org/10.1016/j.ymgme.2015.12.490
https://doi.org/10.1016/j.ymgme.2015.12.490