Zobrazeno 1 - 10
of 148
pro vyhledávání: '"Sean M, Hays"'
Autor:
Christopher R. Kirman, Sean M. Hays
Publikováno v:
Toxics, Vol 10, Iss 7, p 394 (2022)
Unit Risk (UR) values were derived for 1,3-butadiene (BD) based upon its ability to cause tumors in laboratory mice and rats. Metabolism has been established as the significant molecular initiating event of BD’s carcinogenicity. The large quantitat
Externí odkaz:
https://doaj.org/article/9871320387e94892b4c973d4d88391ac
Autor:
Gregory J. Garvey, Janet K. Anderson, Philip E. Goodrum, Kirby H. Tyndall, L. Anthony Cox, Mahin Khatami, Jorge Morales-Montor, Rita S. Schoeny, Jennifer G. Seed, Rajeev K. Tyagi, Christopher R. Kirman, Sean M. Hays
Publikováno v:
Critical Reviews in Toxicology. 53:34-51
Immunotoxicity is the critical endpoint used by some regulatory agencies to establish toxicity values for perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS). However, the hypothesis that exposure to certain per- and polyfluoroalkyl su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5543d9151604eed4b4acbd89aa29abd
https://doi.org/10.1080/10408444.2023.2194913
https://doi.org/10.1080/10408444.2023.2194913
Autor:
Sean M, Hays, Christopher R, Kirman, Jeffrey H, Driver, Ian, van Wesenbeeck, Richard A, Becker
Publikováno v:
Regulatory Toxicology and Pharmacology. 138:105316
The extent and rigor of peer review that a model undergoes during and after development influences the confidence of users and managers in model predictions. A process for determining the breadth and depth of peer review of exposure models was develo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f3713c65c4c37ec20b6c39e6324740
https://doi.org/10.1016/j.yrtph.2022.105316
https://doi.org/10.1016/j.yrtph.2022.105316
Publikováno v:
Regulatory Toxicology and Pharmacology. 134:105212
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f5e9f9fb2566782d6984cb93972592c
https://doi.org/10.1016/j.yrtph.2022.105212
https://doi.org/10.1016/j.yrtph.2022.105212
Autor:
Jon A. Arnot, Giulia Vilone, John N. Westgate, Sean M. Hays, Christina Cowan-Ellsberry, Lesa L. Aylward, Cian O’Mahony
Publikováno v:
Journal of Exposure Science & Environmental Epidemiology
Exposure models provide critical information for risk assessment of personal care product ingredients, but there have been limited opportunities to compare exposure model predictions to observational exposure data. Urinary excretion data from a biomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfa346aa8045bc32e619a7526c51846
http://europepmc.org/articles/PMC6914665
http://europepmc.org/articles/PMC6914665
Publikováno v:
Critical reviews in toxicology. 50(10)
A cancer weight of evidence (WOE) analysis based on updated toxicokinetics, genotoxicity, and carcinogenicity data for 1,3-dichloropropene was peer reviewed by a panel of experts. Historically, 1,3-dichloropropene has been classified in the U.S. as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c529c7aec082393bdd6c63f7f69e694
https://pubmed.ncbi.nlm.nih.gov/33528305
https://pubmed.ncbi.nlm.nih.gov/33528305
Publikováno v:
Journal of Toxicology, Vol 2012 (2012)
Evaluation of a larger number of chemicals in commerce from the perspective of potential human health risk has become a focus of attention in North America and Europe. Screening-level chemical risk assessment evaluations consider both exposure and ha
Externí odkaz:
https://doaj.org/article/b9c48f4e2b244ba6a9ccfe433fb459fe
Publikováno v:
Regulatory Toxicology and Pharmacology. 94:40-46
Iodine is an essential nutrient whose deficiency or excess exposure can cause adverse health effects. The primary sources of iodine exposure in the general population are iodized salt, dairy products, bread and sea food. Urinary iodine concentrations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d68f6549d3a523bd53ae988a2ec0ec4
https://doi.org/10.1016/j.yrtph.2018.01.017
https://doi.org/10.1016/j.yrtph.2018.01.017
Publikováno v:
Regulatory Toxicology and Pharmacology. 92:29-38
3-Phenoxybenzoic acid (3-PBA) is a common metabolite of several pyrethroid pesticides of differing potency and also occurs as a residue in foods resulting from environmental degradation of parent pyrethroid compounds. Thus, 3-PBA in urine is not a sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccf17b4557a42ab3980ebc85843afeae
https://doi.org/10.1016/j.yrtph.2017.11.002
https://doi.org/10.1016/j.yrtph.2017.11.002
Publikováno v:
Regulatory Toxicology and Pharmacology. 122:104913
Aluminium is widely used in many consumer products, however the primary source of aluminium exposure to the Canadian general population is through food. Aluminium can cause neurotoxicity and reproductive toxicity at elevated exposure levels. Health-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ebbad15a566e7f5b9189c4460d60ceb
https://doi.org/10.1016/j.yrtph.2021.104913
https://doi.org/10.1016/j.yrtph.2021.104913