Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Sean L. Willis"'
Autor:
Matthew R. Dreher, Pedro Garcia, Sean L. Willis, Andrew L. Lewis, Shuning Bian, Daniel F. Daly, Marcus Caine, Alexander Henman, Yiqing Tang, Robert Carlisle, Eleanor Stride
Understanding the intra-tumoral distribution of chemotherapeutic drugs is extremely important in predicting therapeutic outcome. Tissue mimicking gel phantoms are useful for studying drug distribution in vitro but quantifying distribution is laboriou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a906a92ac6820943611763ad2c821ea
https://doi.org/10.1016/j.ejps.2021.105772
https://doi.org/10.1016/j.ejps.2021.105772
Autor:
Z. A. Bascal, Andrew L. Lewis, Matthew R. Dreher, Yiqing Tang, Thierry de Baere, Ting Chung, Hugh Kilpatrick, Sean L. Willis, Marcus Caine
Publikováno v:
Theranostics
There are currently two methods widely used in clinical practice to perform transarterial chemoembolization (TACE). One is based on mixing an aqueous drug with an iodized oil (Lipiodol) and creating an emulsion that is delivered intraarterially, foll
Autor:
Ivane Bakhutashvili, Daniel B. Amchin, Andrew L. Lewis, Sean L. Willis, J. Esparza-Trujillo, David L. Woods, Andrew S. Mikhail, Elliot Levy, Ayele H. Negussie, Paul Wakim, William F. Pritchard, Venkatesh Krishnasamy, Bradford J. Wood, John G. Thompson, John W. Karanian
Publikováno v:
Radiology. 289:396-404
Purpose To correlate bead location and attenuation on CT images with the quantity and distribution of drug delivered to the liver following transarterial chemoembolization (TACE) with radiopaque drug-eluting beads (DEB) in a rabbit tumor model. Mater
Autor:
Ayele H. Negussie, Sean L. Willis, Elliot Levy, Karun Sharma, Bradford J. Wood, Yiqing Tang, Matthew R. Dreher, Koorosh Ashrafi, Andrew S. Mikhail, Andrew L. Lewis
Publikováno v:
Future Oncology. 14:2741-2760
This review describes the historical development of an imageable spherical embolic agent and focuses on work performed in collaboration between Biocompatibles UK Ltd (a BTG International group company) and the NIH to demonstrate radiopaque bead utili
Autor:
Ayele H. Negussie, Filip Banovac, J. Esparza-Trujillo, Sean L. Willis, Bradford J. Wood, Alexander Henman, Yiqing Tang, Andrew S. Mikhail, John W. Karanian, Venkatesh Krishnasamy, Ivane Bakhutashvili, Elliot Levy, Andrew L. Lewis, William F. Pritchard, Paul Wakim, David L. Woods
Publikováno v:
Cardiovasc Intervent Radiol
PURPOSE: Topotecan is a camptothecin analogue with potential advantages over irinotecan for transarterial chemoembolization (TACE) of hepatic colorectal metastases including greater anti-neoplastic activity without enzymatic activation. The purpose o
Autor:
Andrew L. Lewis, Z. A. Bascal, Yiqing Tang, Lorcan Hinchcliffe, Hugh Kilpatrick, Pedro Garcia, Sean L. Willis, Koorosh Ashrafi, Marcus Caine, Wei Guo
Publikováno v:
Journal of Biomedical Materials Research. Part B, Applied Biomaterials
The in vitro and in vivo handling and performance characteristics of a small caliber radiopaque embolic microsphere, 40–90 μm DC Bead LUMI™ (LUMI40‐90), were studied. Microsphere drug loading and elution and effects on size, suspension, and mi
Autor:
Koorosh Ashrafi, Andrew L. Lewis, Rafael Duran, Bradford J. Wood, Jean Francois H. Geschwind, Sahar Mirpour, Karun Sharma, Mark den Hartog, Todd Schlachter, Sean L. Willis, Ayele H. Negussie, Alessandro Radaelli, Ruediger E. Schernthaner, MingDe Lin, Matthew R. Dreher, Vania Tacher
Publikováno v:
Theranostics
Purpose: Embolotherapy using microshperes is currently performed with soluble contrast to aid in visualization. However, administered payload visibility dimishes soon after delivery due to soluble contrast washout, leaving the radiolucent bead's loca
Autor:
Wei Guo, Koorosh Ashrafi, Rosemary Bushby, Anthony Dunn, Hugh Kilpatrick, Matthew R. Dreher, Z. A. Bascal, Marcus Caine, Xunli Zhang, Sean L. Willis, David Grey, Andrew L. Lewis, Andrew J. Bushby, Martyn Hill
Publikováno v:
Journal of the mechanical behavior of biomedical materials. 78
The purpose of this study was to evaluate LC Bead LUMI™ (40–90 µm and 70–150 µm) in order to determine if their increased resistance to compression influences microsphere penetration and distribution compared to more compressible commercial m
Autor:
Ayele H. Negussie, Yiqing Tang, David L. Woods, Kseniya Shuturminska, Mark den Hartog, Alessandro Radaelli, Bradford J. Wood, Orianne Domenge, Koorosh Ashrafi, Andrew J. Bushby, Hugh Britton, Delphine Blino, Venkatesh Krishnasamy, Elliot Levy, Sean L. Willis, Matthew R. Dreher, Andrew S. Mikhail, Andrew L. Lewis
Publikováno v:
Journal of controlled release : official journal of the Controlled Release Society. 250
We have developed a straightforward and efficient method of introducing radiopacity into Polyvinyl alcohol (PVA)-2-Acrylamido-2-methylpropane sulfonic acid (AMPS) hydrogel beads (DC Bead™) that are currently used in the clinic to treat liver malign
Autor:
Karun Sharma, Hugh Kilpatrick, Matthew R. Dreher, Z. A. Bascal, Sean L. Willis, Koorosh Ashrafi, Andrew L. Lewis
Publikováno v:
Biomaterials. 103
The objective of this study was to undertake a comprehensive long-term biocompatibility and imaging assessment of a new intrinsically radiopaque bead (LC Bead LUMI™) for use in transarterial embolization. The sterilized device and its extracts were