Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sean K. Wang"'
Autor:
Zhijian Li, Laura Amaya, Ruoxi Pi, Sean K. Wang, Alok Ranjan, Robert M. Waymouth, Catherine A. Blish, Howard Y. Chang, Paul A. Wender
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The introduction of more effective and selective mRNA delivery systems is required for the advancement of many emerging biomedical technologies including the development of prophylactic and therapeutic vaccines, immunotherapies for cancer an
Externí odkaz:
https://doaj.org/article/9e61f17a635449b78342282fbc40e058
Autor:
Christine L. Xu, Joel Adu-Brimpong, Henry P. Moshfeghi, Tatiana R. Rosenblatt, Michael D. Yu, Marco H. Ji, Sean K. Wang, Moosa Zaidi, Hashem Ghoraba, Suzanne Michalak, Natalia F. Callaway, Jochen Kumm, Eric Nudleman, Edward H. Wood, Nimesh A. Patel, Andreas Stahl, Domenico Lepore, Darius M. Moshfeghi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023)
Abstract Identifying and planning treatment for retinopathy of prematurity (ROP) using telemedicine is becoming increasingly ubiquitous, necessitating a grading system to help caretakers of at-risk infants gauge disease severity. The modified ROP Act
Externí odkaz:
https://doaj.org/article/40922a6ed64b42c087bcdb8135430d8c
Publikováno v:
MedEdPORTAL, Vol 19 (2023)
Introduction Increasing prevalence of neurologic disorders with an aging global population and limited availability of neurologists may lead to worse patient outcomes. As a result of the COVID-19 pandemic, telehealth services surged, and despite easi
Externí odkaz:
https://doaj.org/article/e93117405a804412ad3bf55168446298
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-5 (2022)
Abstract Five-field 130° wide-angle imaging is the standard of care for retinopathy of prematurity (ROP) screening with an ideal hypothetical composite field-of-view (FOV) of 180°. We hypothesized that in many real-world scenarios the effective com
Externí odkaz:
https://doaj.org/article/dce253ff80c44ef39461be4958ad90e0
Autor:
Sean K. Wang, Edward Korot, Moosa Zaidi, Marco H. Ji, Ahmad Al-Moujahed, Natalia F. Callaway, Jochen Kumm, Darius M. Moshfeghi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Treatment outcomes in retinopathy of prematurity (ROP) are closely correlated with the location (i.e. zone) of disease, with more posterior zones having poorer outcomes. The most posterior zone, Zone I, is defined as a circle centered on the
Externí odkaz:
https://doaj.org/article/ee40732befa34dbca7a404f029101899
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss , Pp 376-386 (2020)
Gene therapy with recombinant adeno-associated viral (AAV) vectors is a promising modality for the treatment of a variety of human diseases. Nonetheless, there remain significant gaps in our understanding of AAV vector biology, due in part to the lac
Externí odkaz:
https://doaj.org/article/a01a18cf1729403a9a933268be62fc27
Autor:
Sean K. Wang, Constance L. Cepko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia have been implicated in many degenerative eye disorders, including retinitis pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and retinal detachment. While the exact roles of microglia in these conditio
Externí odkaz:
https://doaj.org/article/6a1b0674c93d4d3a8e65753a4a4a65d8
Publikováno v:
JCI Insight, Vol 6, Iss 16 (2021)
Inherited retinal diseases, such as retinitis pigmentosa (RP), can be caused by thousands of different mutations, a small number of which have been successfully treated with gene replacement. However, this approach has yet to scale and may not be fea
Externí odkaz:
https://doaj.org/article/f49b573c413544e881e14dffffca9c18
Autor:
David M. Wu, Xuke Ji, Maryna V. Ivanchenko, Michelle Chung, Mary Piper, Parimal Rana, Sean K. Wang, Yunlu Xue, Emma West, Sophia R. Zhao, Hongbin Xu, Marcelo Cicconet, Wenjun Xiong, Constance L. Cepko
Publikováno v:
JCI Insight, Vol 6, Iss 2 (2021)
Nrf2, a transcription factor that regulates the response to oxidative stress, has been shown to rescue cone photoreceptors and slow vision loss in mouse models of retinal degeneration (rd). The retinal pigment epithelium (RPE) is damaged in these mod
Externí odkaz:
https://doaj.org/article/66ed3b635a034060a47e1f54e323c711
Autor:
Yunlu Xue, Sean K Wang, Parimal Rana, Emma R West, Christin M Hong, Helian Feng, David M Wu, Constance L Cepko
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) is an inherited retinal disease affecting >20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity visi
Externí odkaz:
https://doaj.org/article/1d602be0a51c44ae81306f4e01339bb2