Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Sean K. Roh"'
Autor:
Arun Samidurai, Amy L. Olex, Ramzi Ockaili, Donatas Kraskauskas, Sean K. Roh, Rakesh C. Kukreja, Anindita Das
Publikováno v:
Cells, Vol 12, Iss 24, p 2820 (2023)
The inhibition of mammalian target of rapamycin (mTOR) with rapamycin (RAPA) provides protection against myocardial ischemia/reperfusion (I/R) injury in diabetes. Since interactions between transcripts, including long non-coding RNA (lncRNA), microRN
Externí odkaz:
https://doaj.org/article/ea3dba0734e04220a1b093176baaa78c
Autor:
Arun Samidurai, Manu Saravanan, Ramzi Ockaili, Donatas Kraskauskas, Suet Ying Valerie Lau, Varun Kodali, Shakthi Ramasamy, Karthikeya Bhoopathi, Megha Nair, Sean K. Roh, Rakesh C. Kukreja, Anindita Das
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8998 (2023)
Robust activation of mTOR (mammalian target of rapamycin) signaling in diabetes exacerbates myocardial injury following lethal ischemia due to accelerated cardiomyocyte death with cardiac remodeling and inflammatory responses. We examined the effect
Externí odkaz:
https://doaj.org/article/3141f2b2e68e4777964116122d270bb2
Autor:
Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das
Publikováno v:
STAR Protocols, Vol 2, Iss 3, Pp 100772- (2021)
Summary: We developed a preclinical model of myocardial ischemia/reperfusion (I/R) injury in conscious diabetic rabbits to identify an early pharmacological intervention for patients with diabetes and acute myocardial infarction (AMI). Here, we descr
Externí odkaz:
https://doaj.org/article/642679fac5a64166858590707e2f0445
Autor:
Arun Samidurai, Ramzi Ockaili, Chad Cain, Sean K. Roh, Scott M. Filippone, Donatas Kraskauskas, Rakesh C. Kukreja, Anindita Das
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101863- (2020)
Summary: Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We show here that infusion of rapamycin (mTOR inhibitor) at reperfusion following ischem
Externí odkaz:
https://doaj.org/article/d42412406e6f4485a07fdde4d4b0c978
Autor:
Arun Samidurai, Rakesh C. Kukreja, Fadi N Salloum, David Durrant, Sean K Roh, Anindita Das, Meeta Prakash
Publikováno v:
Cardiovascular Research. 116:2103-2115
Aims Deregulation of mTOR (mammalian target of rapamycin) signalling occurs in diabetes, which exacerbates injury following myocardial infarction (MI). We therefore investigated the infarct-limiting effect of chronic treatment with rapamycin (RAPA, m
Autor:
Ramzi A Ockaili, Chad Cain, Arun Samidurai, Rakesh C. Kukreja, Donatas Kraskauskas, Scott M. Filippone, Sean K Roh, Anindita Das
Publikováno v:
STAR Protocols
STAR Protocols, Vol 2, Iss 3, Pp 100772-(2021)
STAR Protocols, Vol 2, Iss 3, Pp 100772-(2021)
Summary We developed a preclinical model of myocardial ischemia/reperfusion (I/R) injury in conscious diabetic rabbits to identify an early pharmacological intervention for patients with diabetes and acute myocardial infarction (AMI). Here, we descri
Autor:
Scott M. Filippone, Sean K Roh, Donatas Kraskauskas, Rakesh C. Kukreja, Ramzi A Ockaili, Anindita Das, Chad Cain, Arun Samidurai
Publikováno v:
iScience
iScience, Vol 23, Iss 12, Pp 101863-(2020)
iScience, Vol 23, Iss 12, Pp 101863-(2020)
Summary Persistent activation of mTOR (mammalian target of rapamycin) in diabetes increases the vulnerability of the heart to ischemia/reperfusion (I/R) injury. We show here that infusion of rapamycin (mTOR inhibitor) at reperfusion following ischemi
Publikováno v:
Circulation Research. 125
Background: Dysregulation of miRNAs is associated with the pathogenesis of cardiovascular diseases. miR-17-92 cluster has been identified as a negative regulator of inflammation in rheumatoid arthritis. In diabetes, the persistent activation of NLRP3
Publikováno v:
The FASEB Journal. 32
Autor:
Jun He, Arun Samidurai, Chad Cain, Scott M. Filippone, Rakesh C. Kukreja, Fadi N Salloum, Anindita Das, Sean K Roh
Publikováno v:
Oxidative Medicine and Cellular Longevity, Vol 2017 (2017)
Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity
Prompt coronary reperfusion is the gold standard for minimizing injury following acute myocardial infarction. Rapamycin, mammalian target of Rapamycin (mTOR) inhibitor, exerts preconditioning-like cardioprotective effects against ischemia/reperfusion