Výsledky vyhledávání - "Sean K. Maynard"

Akademický článek

Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Autor: Sean K. Maynard, Jason D. Marshall, Randall S. MacGill, Li Yu, Jennifer A. Cann, Lily I. Cheng, Michael P. McCarthy, Corinne Cayatte, Scott H. Robbins

Publikováno v: BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)

Abstract Background Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cytotoxic T lymphocyte

Externí odkaz: https://doaj.org/article/5d056bfa987f45eb836be09f7b6ba10b

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Akademický článek

Inferior immunogenicity and efficacy of respiratory syncytial virus fusion protein-based subunit vaccine candidates in aged versus young mice.

Autor: Corinne Cayatte, Angie Snell Bennett, Gaurav Manohar Rajani, Leigh Hostetler, Sean K Maynard, Michelle Lazzaro, Patrick McTamney, Kuishu Ren, Terrence O'Day, Michael P McCarthy, Kirsten Schneider-Ohrum

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188708 (2017)

Respiratory syncytial virus (RSV) is recognized as an important cause of lower and upper respiratory tract infections in older adults, and a successful vaccine would substantially lower morbidity and mortality in this age group. Recently, two vaccine

Externí odkaz: https://doaj.org/article/9e1ca917891a4f1cb04538d689433154

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CD4 + T Cells Drive Lung Disease Enhancement Induced by Immunization with Suboptimal Doses of Respiratory Syncytial Virus Fusion Protein in the Mouse Model

Autor: Gaurav Manohar Rajani, Terrence O'Day, Sean K. Maynard, Lily Cheng, Angie Snell Bennett, Michelle Lazzaro, Corinne Cayatte, Kirsten Schneider-Ohrum, Leigh Hostetler

Publikováno v: Journal of Virology. 93

Respiratory syncytial virus (RSV) infection of seronegative children previously immunized with formalin-inactivated (FI) RSV has been associated with serious enhanced respiratory disease (ERD). The phenomenon was reproduced in the cotton rat and the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cce63f955999ded4f66a1a89f86026b
https://doi.org/10.1128/jvi.00695-19

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Vaccination with synthetic long peptide formulated with CpG in an oil-in-water emulsion induces robust E7-specific CD8 T cell responses and TC-1 tumor eradication

Autor: Jason D. Marshall, Michael P. McCarthy, Lily Cheng, Corinne Cayatte, Li Yu, Jennifer Cann, Scott H. Robbins, Randall S. MacGill, Sean K. Maynard

Publikováno v: BMC Cancer
BMC Cancer, Vol 19, Iss 1, Pp 1-12 (2019)

Background Despite considerable efforts at developing therapeutic vaccines for cancer, clinical translation of preclinical successes has been challenging, largely due to the difficulty of inducing strong and sustained cytotoxic T lymphocyte (CTL) res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ba7eed1cdcf4fdf1dd888c6bdee5e3
https://doi.org/10.1186/s12885-019-5725-y

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CARD19, the protein formerly known as BinCARD, is a mitochondrial protein that does not regulate Bcl10-dependent NF-κB activation after TCR engagement

Autor: Sean K. Maynard, Kariana E. Rios, Suman Paul, Michael A Washington, Brian C. Schaefer, Anuj K. Kashyap

Publikováno v: Cell Immunol

After T cell receptor (TCR) engagement, the CARD11-Bcl10-Malt1 (CBM) complex oligomerizes to transduce NF-κB activating signals. Bcl10 is then degraded to limit NF-κB activation. The cDNA AK057716 (BinCARD-1) was reported to encode a novel CARD pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38e00b8050e703ac467078e397670da3
https://doi.org/10.1016/j.cellimm.2020.104179

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Feasibility of Freeze-Drying Oil-in-Water Emulsion Adjuvants and Subunit Proteins to Enable Single-Vial Vaccine Drug Products

Autor: Gaurav Manohar Rajani, Michael P. McCarthy, Steve M. Bishop, Richard L. Remmele, Corinne Cayatte, Bilikallahalli K. Muralidhara, Angie Snell Bennett, Vidyashankara Iyer, Jenny Sun, Sean K. Maynard, Kirsten Schneider-Ohrum, Jason D. Marshall

Publikováno v: Journal of pharmaceutical sciences. 106(6)

To generate potent vaccine responses, subunit protein antigens typically require coformulation with an adjuvant. Oil-in-water emulsions are among the most widely investigated adjuvants, based on their demonstrated ability to elicit robust antibody an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d3bcdc56a3d42ddf1a1a100ccf59d8
https://pubmed.ncbi.nlm.nih.gov/28259764

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Salsalate treatment following traumatic brain injury reduces inflammation and promotes a neuroprotective and neurogenic transcriptional response with concomitant functional recovery

Autor: Brian C. Schaefer, Mouna Lagraoui, Clifton L. Dalgard, Joseph R. Latoche, Gauthaman Sukumar, Sean K. Maynard

Publikováno v: Brain, behavior, and immunity. 61

Neuroinflammation plays a critical role in the pathogenesis of traumatic brain injury (TBI). TBI induces rapid activation of astrocytes and microglia, infiltration of peripheral leukocytes, and secretion of inflammatory cytokines. In the context of m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10351298bede7b4c1ebd16f5ecebaf5c
https://pubmed.ncbi.nlm.nih.gov/27939247

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A Novel Class of Small Molecule Agonists with Preference for Human over Mouse TLR4 Activation

Autor: Cooper Martin, Darren S. Heeke, Jason D. Marshall, Adeline M. Hajjar, Sarah King, Nicola Williams, Christopher McCrae, Jennifer Woo, Andrey Tovchigrechko, Neil Fraser, Li Yu, Eileen Rao, David C. Hornigold, Sean K. Maynard

Publikováno v: PLoS ONE
PLoS ONE, Vol 11, Iss 10, p e0164632 (2016)

The best-characterized Toll-like receptor 4 (TLR4) ligands are lipopolysaccharide (LPS) and its chemically modified and detoxified variant, monophosphoryl lipid A (MPL). Although both molecules are active for human TLR4, they demonstrate a potency pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5f96ba8f2ea4a4ab92100996384ecd
https://pubmed.ncbi.nlm.nih.gov/27736941

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Cutting Edge: TCR Ligation Triggers Digital Activation of NF-κB

Autor: Lara M. Kingeter, Brian C. Schaefer, Natalia G. Cartwright, Suman Paul, Sean K. Maynard

Publikováno v: The Journal of Immunology. 185:4520-4524

TCR-mediated activation of the transcription factor NF-κB is required for T cell proliferation, survival, and effector differentiation. Although this pathway is the subject of intense study, it is not known whether TCR signaling to NF-κB is digital

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3199062170b580c00105b620d3a99fef
https://doi.org/10.4049/jimmunol.1001051

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Regulation of innate responses during pre-patent schistosome infection provides an immune environment permissive for parasite development

Autor: Christine E. Ferragine, Diana K. Riner, Stephen Davies, Sean K. Maynard

Publikováno v: PLoS Pathogens, Vol 9, Iss 10, p e1003708 (2013)
PLoS Pathogens

Blood flukes of the genus Schistosoma infect over 200 million people, causing granulomatous pathology with accompanying morbidity and mortality. As a consequence of extensive host-parasite co-evolution, schistosomes exhibit a complex relationship wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1657be84af64cbd18c77348385fcae0
http://europepmc.org/articles/PMC3795041?pdf=render

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