Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Sean K. Liew"'
Autor:
Graham E. Garrett, Travis Dudding, Sean K. Liew, Diego B. Diaz, Sherif J. Kaldas, Andrei K. Yudin, C. Frank Lee, Aleksandra Holownia
Publikováno v:
Nature Chemistry. 10:1062-1070
Tetracoordinate MIDA (N-methyliminodiacetic acid) boronates have found broad utility in chemical synthesis. Here, we describe mechanistic insights into the migratory aptitude of the MIDA boryl group in boron transfer processes, and show that the hemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5d6f4935f016ba2c98e58a2a68b3f6b
https://doi.org/10.1038/s41557-018-0097-5
https://doi.org/10.1038/s41557-018-0097-5
Publikováno v:
European Journal of Organic Chemistry. 2017:419-423
1,2-Aziridinyl propargylic amines have been obtained through a zinc-catalyzed multicomponent reaction. This process relies on the dimeric amino aldehyde assembly orchestrating the intramolecular 1,2-alkyne addition to an iminium ion. The resulting pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a5d69ce370409efe0846b48e0f2424c
https://doi.org/10.1002/ejoc.201601554
https://doi.org/10.1002/ejoc.201601554
Autor:
Andrei K. Yudin, Aleksandra Holownia, Philip A. Cistrone, Sean K. Liew, Diego B. Diaz, Philip E. Dawson
Publikováno v:
Chem. Commun.. 53:11237-11240
Herein, we demonstrate the synthesis and functionalization of α-boryl aldoximes from α-boryl aldehydes, with no sign of C-to-N boryl migration. Selective modification of the oxime functionality enables access to a wide range of borylated compounds,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deab175be97170a757281b5f3df90e1c
https://doi.org/10.1039/c7cc06579e
https://doi.org/10.1039/c7cc06579e
Autor:
Steven Kennedy, Sean K. Liew, Matthieu Schapira, Masoud Vedadi, Abdellah Allali-Hassani, Cheryl H. Arrowsmith, Scott Houliston, Andrei K. Yudin, Jinrong Min, Diego B. Diaz, P. Mader, Hong Wu, Aman Iqbal, Aiping Dong, Vijayaratnam Santhakumar, Rodrigo Mendoza-Sanchez, Renato Ferreira de Freitas, Victoria B. Corless, David Smil, Peter Brown, Ludmila Dombrovski, Elena Dobrovetsky, Carlo C. dela Seña
Publikováno v:
Bioorganicmedicinal chemistry. 27(17)
SET domain bifurcated protein 1 (SETDB1) is a human histone-lysine methyltransferase, which is amplified in human cancers and was shown to be crucial in the growth of non-small and small cell lung carcinoma. In addition to its catalytic domain, SETDB
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::279b1b546c4df6dc0f23953355372074
https://pubmed.ncbi.nlm.nih.gov/31327677
https://pubmed.ncbi.nlm.nih.gov/31327677
Autor:
Jeffrey D. St. Denis, Gennady Poda, Shinya Adachi, Zhi He, Andrei K. Yudin, Alan J. Lough, C. Frank Lee, Sean K. Liew
Publikováno v:
Organic Letters. 17:5594-5597
Herein, we describe the bromomethyl acyl boronate linchpin--an enabling reagent for the condensation-driven assembly of novel bis(heteroaryl) motifs. This building block is readily accessible from commercially available starting materials. A variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18627845cca92f28b05361738ba8d0d4
https://doi.org/10.1021/acs.orglett.5b02741
https://doi.org/10.1021/acs.orglett.5b02741
Publikováno v:
Organic letters. 18(24)
A chemoselective N-oxidation/Meisenheimer rearrangement protocol was developed to generate vinylaziridine scaffolds from aziridine aldehydes. A subsequent Lewis acid-mediated aziridine ring opening with carboxylic acid nucleophiles followed by N–O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9090719699279c31b4819f2de4076031
https://pubmed.ncbi.nlm.nih.gov/27978678
https://pubmed.ncbi.nlm.nih.gov/27978678
Publikováno v:
The Journal of Organic Chemistry. 78:11637-11645
Vicinal aziridine-containing diamines have been obtained with high syn-stereoselectivity from readily available aziridine aldehyde dimers in the Petasis borono-Mannich reaction. Subsequent solvent- and/or nucleophile-dependent ring-opening of the azi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d068c72b7f8a23be25adac8f61d9fc76
https://doi.org/10.1021/jo401489q
https://doi.org/10.1021/jo401489q
Autor:
Diego B. Diaz, Piera Trinchera, Shinya Adachi, Sean K. Liew, Andrei K. Yudin, Conor C. G. Scully, Jeffrey D. St. Denis
Publikováno v:
Angewandte Chemie (International ed. in English). 55(41)
Herein, we demonstrate the use of α-boryl aldehydes and acyl boronates in the synthesis of aminoboronic acid derivatives. This work highlights the untapped potential of boron-substituted iminium ions and offers insights into the behavior of N-methyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a449c98a558e73e6e483cb98c2193cea
https://pubmed.ncbi.nlm.nih.gov/27584917
https://pubmed.ncbi.nlm.nih.gov/27584917
Autor:
Alan J. Lough, C. Frank Lee, Gennady Poda, Sean K. Liew, Andrei K. Yudin, Shinya Adachi, Zhi He, Jeffrey D. St. Denis
Publikováno v:
ChemInform. 47
Herein, we describe the bromomethyl acyl boronate linchpin–an enabling reagent for the condensation-driven assembly of novel bis(heteroaryl) motifs. This building block is readily accessible from commercially available starting materials. A variety
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03ff408d629fa36dc88f1e5a09a6ba00
https://doi.org/10.1002/chin.201613190
https://doi.org/10.1002/chin.201613190
Autor:
Sean K. Liew, S. M. Ibrahim Al-Rafia, Robert McDonald, Eric Rivard, Leah J. Miedema, Sean M. McDonald, James T. Goettel, Paul A. Lummis, Michael J. Ferguson
Publikováno v:
Inorganic Chemistry. 51:5471-5480
The synthesis and coordination chemistry of a series of dianionic bis(amido)silyl and bis(amido)disilyl, [NSiN] and [NSiSiN], chelates with N-bound aryl or sterically modified triarylsilyl (SiAr(3)) groups is reported. In order to provide a consisten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3866301c107608b17772acbcaa9e2d88
https://doi.org/10.1021/ic300495k
https://doi.org/10.1021/ic300495k