Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Sean K Wang"'
Autor:
Alisa E Lee, Emily Y Chu, Pamela J Gardner, Olivier Duverger, Amanda Saikali, Sean K Wang, Rachel I Gafni, Iris R Hartley, Kelly G Ten Hagen, Martha J Somerman, Michael T Collins
Publikováno v:
JBMR Plus, Vol 5, Iss 5, Pp n/a-n/a (2021)
ABSTRACT Hyperphosphatemic familial tumoral calcinosis (HFTC) is a rare autosomal recessive disorder caused by mutations in FGF23, GALNT3, KLOTHO, or FGF23 autoantibodies. Prominent features include high blood phosphate and calcific masses, usually a
Externí odkaz:
https://doaj.org/article/269e9f264f124907a0616bffd3364a0f
Autor:
Yunlu Xue, Sean K Wang, Parimal Rana, Emma R West, Christin M Hong, Helian Feng, David M Wu, Constance L Cepko
Publikováno v:
eLife, Vol 10 (2021)
Retinitis pigmentosa (RP) is an inherited retinal disease affecting >20 million people worldwide. Loss of daylight vision typically occurs due to the dysfunction/loss of cone photoreceptors, the cell type that initiates our color and high-acuity visi
Externí odkaz:
https://doaj.org/article/1d602be0a51c44ae81306f4e01339bb2
Autor:
Zhijian Li, Laura Amaya, Ruoxi Pi, Sean K. Wang, Alok Ranjan, Robert M. Waymouth, Catherine A. Blish, Howard Y. Chang, Paul A. Wender
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract The introduction of more effective and selective mRNA delivery systems is required for the advancement of many emerging biomedical technologies including the development of prophylactic and therapeutic vaccines, immunotherapies for cancer an
Externí odkaz:
https://doaj.org/article/9e61f17a635449b78342282fbc40e058
Autor:
Sean K. Wang, Edward Korot, Moosa Zaidi, Marco H. Ji, Ahmad Al-Moujahed, Natalia F. Callaway, Jochen Kumm, Darius M. Moshfeghi
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)
Abstract Treatment outcomes in retinopathy of prematurity (ROP) are closely correlated with the location (i.e. zone) of disease, with more posterior zones having poorer outcomes. The most posterior zone, Zone I, is defined as a circle centered on the
Externí odkaz:
https://doaj.org/article/ee40732befa34dbca7a404f029101899
Autor:
Sean K. Wang, Constance L. Cepko
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Microglia have been implicated in many degenerative eye disorders, including retinitis pigmentosa, age-related macular degeneration, glaucoma, diabetic retinopathy, uveitis, and retinal detachment. While the exact roles of microglia in these conditio
Externí odkaz:
https://doaj.org/article/6a1b0674c93d4d3a8e65753a4a4a65d8
Autor:
Robert Chen, Sean K. Wang, Julia A. Belk, Laura Amaya, Zhijian Li, Angel Cardenas, Brian T. Abe, Chun-Kan Chen, Paul A. Wender, Howard Y. Chang
Publikováno v:
Nature Biotechnology. 41:262-272
Circular RNAs (circRNAs) are stable and prevalent RNAs in eukaryotic cells that arise from back-splicing. Synthetic circRNAs and some endogenous circRNAs can encode proteins, raising the promise of circRNA as a platform for gene expression. In this s
Autor:
Robert Chen, Sean K. Wang, Julia A. Belk, Laura Amaya, Zhijian Li, Angel Cardenas, Brian T. Abe, Chun-Kan Chen, Paul A. Wender, Howard Y. Chang
Publikováno v:
Nature Biotechnology.
Publikováno v:
Scientific reports. 12(1)
Five-field 130° wide-angle imaging is the standard of care for retinopathy of prematurity (ROP) screening with an ideal hypothetical composite field-of-view (FOV) of 180°. We hypothesized that in many real-world scenarios the effective composite FO
Autor:
Sean K. Wang, Vidhya Suresh, Adrianna Elashker, Rahma Ajja, Austin Seals, Sameer Acharya, Jeff D. Williamson, Justin Moore, Hayden Bosworth, Yashashwi Pokharel
Publikováno v:
Journal of the American College of Cardiology. 81:1881
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 19, Iss, Pp 376-386 (2020)
Molecular Therapy. Methods & Clinical Development
Molecular Therapy. Methods & Clinical Development
Gene therapy with recombinant adeno-associated viral (AAV) vectors is a promising modality for the treatment of a variety of human diseases. Nonetheless, there remain significant gaps in our understanding of AAV vector biology, due in part to the lac