Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Sean J. Harrison"'
Autor:
Natalie Roy D’Amore, Shih-Chung Huang, Sharmila Adhikari, Dylan England, David Lok, Anna Lublinsky, Jouhara Chouitar, Klaudia Foley, Patrick J. LeRoy, Emily F. Calderwood, Ji Zhang, Alexandra E. Gould, James E. Brownell, Sean J. Harrison, Li-Ting Ma, Yu Yang, Saurabh Menon
Publikováno v:
Bioorganicmedicinal chemistry. 28(19)
Autophagy is postulated to be required by cancer cells to survive periods of metabolic and/or hypoxic stress. ATG7 is the E1 enzyme that is required for activation of Ubl conjugation pathways involved in autophagosome formation. This article describe
Autor:
Mi-Sook Kim, Mansoureh Rezaei, Jouhara Chouitar, Katherine Brewer, Michael D. Smith, Alexandra E. Gould, Katherine Galvin, Shih-Chung Huang, Dong Mei Zhang, Sharmila Adhikari, Hirotake Mizutani, Steven P. Langston, Dylan England, Paul D. Greenspan, Emily F. Calderwood, Craig Fisher, Sean J. Harrison, Li-Ting Ma, Saurabh Menon, Roushan Afroze, Jeffery Gaulin
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:1156-1160
Investigations of a biaryl ether scaffold identified tetrahydronaphthalene Raf inhibitors with good in vivo activity; however these compounds had affinity toward the hERG potassium channel. Herein we describe our work to eliminate this hERG activity
Autor:
Kara Hoar, Jiejin Chen, Sean J. Harrison, Jingya Ma, James M. Gavin, Neil F. Bence, Wei Chen, Ping Li, Michael Sintchak, Nancy J. Bump, Qing Xu, Lawrence R. Dick, William D. Mallender, Jesse J. Chen, Alexandra E. Gould, Frank Bruzzese, Yafang Lin
Publikováno v:
Journal of Biological Chemistry. 289:22648-22658
E1 enzymes activate ubiquitin or ubiquitin-like proteins (Ubl) via an adenylate intermediate and initiate the enzymatic cascade of Ubl conjugation to target proteins or lipids. Ubiquitin-fold modifier 1 (Ufm1) is activated by the E1 enzyme Uba5, and
Publikováno v:
Journal of the American Chemical Society. 121:296-300
The synthesis and preliminary biological evaluation of the first analogues of ingenol, a potent activator of protein kinase C, containing all of the oxygen functionality and unsaturation present in the natural product, is described.
Autor:
Corrie A. Stankiewicz, W.J. Middleton, Jamie M. Roseman, Sean J. Harrison, C. Blair Zartman, Sarah M. Lee, Eamonn P. Morrison
Publikováno v:
Journal of Fluorine Chemistry. 77:65-70
The selective fluorination of compounds containing benzylic hydrogen atoms was accomplished by electrolysis in a mixture of 70% HF and 30% pyridine (Olah's reagent) using a square wave alternating current (1.76–2.75 V, 0.02–0.05 Hz) and Pt electr
Publikováno v:
Journal of the American Chemical Society. 124:9726-9728
The first total synthesis of (±)-ingenol has been achieved. The key features of the synthesis include the use of a highly diastereoselective Michael reaction to fix the C-11 methyl stereochemistry and the incorporation of the dimethylcyclopropane vi
Publikováno v:
ChemInform. 33
The first total synthesis of (±)-ingenol has been achieved. The key features of the synthesis include the use of a highly diastereoselective Michael reaction to fix the C-11 methyl stereochemistry and the incorporation of the dimethylcyclopropane vi
Publikováno v:
Synthesis. 2002
The irradn. of allylically substituted dioxenone photosubstrates I and II lead to unexpected products, the formation of which can be explained by a series of transannular hydrogen atom abstractions. [on SciFinder(R)]
Autor:
Alexandra E. Gould, Ruth Adams, Sharmila Adhikari, Kathleen Aertgeerts, Roushan Afroze, Christopher Blackburn, Emily F. Calderwood, Ryan Chau, Jouhara Chouitar, Matthew O. Duffey, Dylan B. England, Cheryl Farrer, Nancy Forsyth, Khristofer Garcia, Jeffery Gaulin, Paul D. Greenspan, Ribo Guo, Sean J. Harrison, Shih-Chung Huang, Natalia Iartchouk
Publikováno v:
Journal of Medicinal Chemistry; Mar2011, Vol. 54 Issue 6, p1836-1846, 11p