Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Sean J. Gerrin"'
Gleason Score 7 Prostate Cancers Emerge through Branched Evolution of Clonal Gleason Pattern 3 and 4
Autor:
Huihui Ye, Adam G. Sowalsky, Haydn T. Kissick, Sean J. Gerrin, Wei Li, Martin G. Sanda, Rachel J. Schaefer, Glenn J. Bubley, Joshua W. Russo, Steven P. Balk, M. Simo Arredouani, Zheng Xia
Publikováno v:
Clinical Cancer Research. 23:3823-3833
Purpose: The molecular features that account for the distinct histology and aggressive biological behavior of Gleason pattern 4 (Gp4) versus Gp3 prostate cancer, and whether Gp3 tumors progress directly to Gp4, remain to be established. Experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5fc44e3f6c02c3641cdb924d2c1722
https://doi.org/10.1158/1078-0432.ccr-16-2414
https://doi.org/10.1158/1078-0432.ccr-16-2414
Publikováno v:
The Prostate. 76:1227-1236
Introduction High Grade Prostatic Intraepithelial Neoplasia (HGPIN) is the putative precursor lesion to prostatic adenocarcinoma (PCa), but the precise relationship between HGPIN and PCa remains unclear. Methods We performed a molecular case study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9451103b61e4d8db7a4fc694af915ef0
https://doi.org/10.1002/pros.23212
https://doi.org/10.1002/pros.23212
Autor:
Liza, Quintana, Ashley, Ward, Sean J, Gerrin, Elizabeth M, Genega, Seymour, Rosen, Martin G, Sanda, Andrew A, Wagner, Peter, Chang, William C, DeWolf, Huihui, Ye
Publikováno v:
Urology. 91:143-149
Objective To compare the utility of saturation core biopsy and 12-core biopsy in detecting true Gleason grades, using final pathology in prostatectomy specimens as outcome measures, with a particular interest in Gleason upgrading. Patients and Method
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c491dd473a7335a9b779f82a79775a
https://doi.org/10.1016/j.urology.2015.12.089
https://doi.org/10.1016/j.urology.2015.12.089
Autor:
Sen Chen, Benjamin A. Tanenbaum, Xin Yuan, Adam G. Sowalsky, Steven P. Balk, Fen Ma, Lingfeng He, Hongyun Wang, Huihui Ye, Changmeng Cai, Sean J. Gerrin, Housheng Hansen He
Publikováno v:
Journal of Clinical Investigation. 126:1745-1758
The transcription factor SOX9 is critical for prostate development, and dysregulation of SOX9 is implicated in prostate cancer (PCa). However, the SOX9-dependent genes and pathways involved in both normal and neoplastic prostate epithelium are largel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1cab8be6d688212e872cc5551fbcf1
https://doi.org/10.1172/jci78815
https://doi.org/10.1172/jci78815
Autor:
Peter S. Nelson, Ziyang Yu, Olga Voznesensky, Huihui Ye, Hongyun Wang, Shuai Gao, Changmeng Cai, Akash Patnaik, Sean J. Gerrin, Sen Chen, Steven P. Balk, Wanting Han, Ankur Sharma, Adam G. Sowalsky, Mary-Ellen Taplin, Elahe A. Mostaghel
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 22(14)
Purpose: ErbB2 signaling appears to be increased and may enhance androgen receptor (AR) activity in a subset of patients with castration-resistant prostate cancer (CRPC), but agents targeting ErbB2 have not been effective. This study was undertaken t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20fe76d3a92be3593567ecad28ce0ec6
https://pubmed.ncbi.nlm.nih.gov/26936914
https://pubmed.ncbi.nlm.nih.gov/26936914
Autor:
Sean J. Gerrin, Gene Malkin, Griffis Joshua, Robert H. Meltzer, Ekaterina Protozanova, Shilpi P. Vyas, Mikhail M. Safranovitch
Publikováno v:
Lab on a chip. 14(19)
Sequence-nonspecific staining of DNA with intercalating fluorophores is required for fluorescence-based length estimation of elongated DNA in optical mapping techniques. However, the observed length of a DNA molecule is affected by the relative conce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f053337a4a1e706d8f5cced6d6a0c7
https://pubmed.ncbi.nlm.nih.gov/25133764
https://pubmed.ncbi.nlm.nih.gov/25133764
Autor:
Yanfei Gao, Fen Ma, Huihui Ye, Xiaming Liu, Jihong Liu, Xin Yuan, Changmeng Cai, Tengfei Zhang, Shaoyong Chen, Steven P. Balk, Yiming Wu, Sean J. Gerrin, Joshua W. Russo
Publikováno v:
Nucleic Acids Research
P-TEFb (CDK9/cyclin T) plays a central role in androgen receptor (AR)-mediated transactivation by phosphorylating both RNA polymerase 2 complex proteins and AR at S81. CDK9 dephosphorylation mobilizes P-TEFb from an inhibitory 7SK ribonucleoprotein c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2019d40a12b927510115eeddf79e232f
https://doi.org/10.1093/nar/gkw1291
https://doi.org/10.1093/nar/gkw1291
Publikováno v:
Prostate; Sep2016, Vol. 76 Issue 13, p1227-1236, 10p