Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Sean J McAteer"'
Autor:
Sandra Fienko, Christian Landles, Kirupa Sathasivam, Sean J McAteer, Rebecca E Milton, Georgina F Osborne, Edward J Smith, Samuel T Jones, Marie K Bondulich, Emily C E Danby, Jemima Phillips, Bridget A Taxy, Holly B Kordasiewicz, Gillian P Bates
Publikováno v:
Brain. 145:4409-4424
Huntington disease is caused by a CAG repeat expansion in exon 1 of the huntingtin gene (HTT) that is translated into a polyglutamine stretch in the huntingtin protein (HTT). We previously showed that HTT mRNA carrying an expanded CAG repeat was inco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a45e092a75a5ea5192081081d74bcd73
https://doi.org/10.1093/brain/awac241
https://doi.org/10.1093/brain/awac241
Autor:
Pamela P. Farshim, Rachel Flomen, Gillian P. Bates, Benjamin E. Deverman, Edward J Smith, Sean J McAteer, Viviana Gradinaru, Samuel T Jones
Publikováno v:
Brain Communications
The engineering of the AAV-PHP capsids was an important development for CNS research and the modulation of gene expression in the brain. They cross the blood brain barrier and transduce brain cells after intravenous systemic delivery, a property depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a455cfe0359001ce4f571a8183fed2be
https://resolver.caltech.edu/CaltechAUTHORS:20210629-201655221
https://resolver.caltech.edu/CaltechAUTHORS:20210629-201655221
Autor:
Wenzhen Duan, Christian Landles, Gillian P. Bates, Rebecca E Milton, Alexandre Jean, Chuangchuang Zhang, Bridget A. Taxy, David Howland, Sean J McAteer, Stuart McLarnon, Georgina F Osborne
Publikováno v:
Brain Communications
Huntington’s disease is caused by a CAG / polyglutamine repeat expansion. Mutated CAG repeats undergo somatic instability, resulting in tracts of several hundred CAGs in the brain; and genetic modifiers of Huntington’s disease have indicated that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dcee579579e4539273abff9f7651e8
http://europepmc.org/articles/PMC7878250
http://europepmc.org/articles/PMC7878250
Autor:
Sean J McAteer, Aikaterini S. Papadopoulou, Michael A Mason, Casandra Gomez Paredes, Gillian P. Bates
Publikováno v:
Pathogenic mechanisms.
Background The heat shock response (HSR) is responsible for the maintenance of proteome integrity within cells. HSR is induced under conditions of proteotoxic stress such as the presence of aggregates or aberrantly-folded proteins, as observed in Hun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6d7389beb44891f3791236b8a5efa31
https://doi.org/10.1136/jnnp-2018-ehdn.17
https://doi.org/10.1136/jnnp-2018-ehdn.17