Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sean J Lund"'
Autor:
Jana H. Badrani, Allyssa N. Strohm, Lee Lacasa, Blake Civello, Kellen Cavagnero, Yung-An Haung, Michael Amadeo, Luay H. Naji, Sean J. Lund, Anthea Leng, Hyojoung Kim, Rachel E. Baum, Naseem Khorram, Monalisa Mondal, Grégory Seumois, Julie Pilotte, Peter W. Vanderklish, Heather M. McGee, Taylor A. Doherty
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The function of RNA binding proteins within innate lymphoid cells (ILC) has been partially characterised. Here the authors show that RBM3 functions to limit the type 2 immunity promoting activity of ILC2 partially through cysteinyl leukotriene 1 rece
Externí odkaz:
https://doaj.org/article/8f52f115894447729c3303cf626c6953
Autor:
Nicole Collette, Pragyesh Dhungel, Sean J. Lund, Jennifer L. Schwedler, Edwin A. Saada, Yooli K. Light, Anupama Sinha, Joseph S. Schoeniger, Oscar A. Negrete
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 286-295 (2021)
Targeting host factors for anti-viral development offers several potential advantages over traditional countermeasures that include broad-spectrum activity and prevention of resistance. Characterization of host factors in animal models provides stron
Externí odkaz:
https://doaj.org/article/4c7fa5ee5aff46e1a7c001187a20fbb0
Autor:
Sean J. Lund, Kathryn A. Patras, Jacqueline M. Kimmey, Asami Yamamura, Lindsay D. Butcher, Pamela G.B. Del Rosario, Gilberto E. Hernandez, Alyssa M. McCoy, Omar Lakhdari, Victor Nizet, Lawrence S. Prince
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101207- (2020)
Summary: Streptococcus agalactiae (Group B Streptococcus, GBS) is the most common neonatal pathogen. However, the cellular and molecular mechanisms for neonatal susceptibility to GBS pneumonia and sepsis are incompletely understood. Here we optimized
Externí odkaz:
https://doaj.org/article/08a3b66fdb2f440388d8fc7d11f6b5fb
Autor:
Asami Honda, Marten A. Hoeksema, Mashito Sakai, Sean J. Lund, Omar Lakhdari, Lindsay D. Butcher, Tara C. Rambaldo, Neal M. Sekiya, Chanond A. Nasamran, Kathleen M. Fisch, Eniko Sajti, Christopher K. Glass, Lawrence S. Prince
Publikováno v:
J Immunol
Immaturity of alveolar macrophages (AMs) around birth contributes to the susceptibility of newborns to lung disease. However, the molecular features differentiating neonatal and mature, adult AMs are poorly understood. In this study, we identify the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc60b5e7ce98b2619fc12527a36e61c2
https://pubmed.ncbi.nlm.nih.gov/35354612
https://pubmed.ncbi.nlm.nih.gov/35354612
Autor:
Jana H. Badrani, Michael Amadeo, Kellen Cavagnero, Luay H. Naji, Sean J. Lund, Anthea Leng, Lee Lacasa, Allyssa Strohm, Hyojoung Kim, Rachel E. Baum, Naseem Khorram, Monalisa Mondal, Grégory Seumois, Julie Pilotte, Peter W. Vanderklish, Taylor A. Doherty
Innate lymphoid cells (ILCs) promote lung inflammation through cytokine production in diseases such as asthma. RNA-binding proteins (RBPs) are critical post-transcriptional regulators of cellular function, including inflammatory responses, though the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8023e835c53c21ef1e7c6643ee8dee92
https://doi.org/10.1101/2020.07.27.223958
https://doi.org/10.1101/2020.07.27.223958
Autor:
Asami Yamamura, Marten A. Hoeksema, Mashito Sakai, Sean J. Lund, Lindsay D. Butcher, Omar Lakhdari, Gertrude O. Oppong-Nonterah, Eniko Sajti, Christopher K. Glass, Lawrence S. Prince
Publikováno v:
The Journal of Immunology. 204:152.4-152.4
Alveolar macrophages (AMs) perform specialized functions in the lung including protection against inhaled microbes and repair following injury. Neonates are particularly susceptible to lung infection and injury, suggesting immaturity of AM function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4661975f0d55f1dc9ed3c8744b5b3c5d
https://doi.org/10.4049/jimmunol.204.supp.152.4
https://doi.org/10.4049/jimmunol.204.supp.152.4
Autor:
Sean J Lund, Kathryn A Patras, Jacqueline M Kimmey, Asami Yamamura, Lindsay D Butcher, Pamela G B Del Rosario, Gilberto E Hernandez, Alyssa M McCoy, Omar Lakhdari, Victor Nizet, Lawrence S Prince
Publikováno v:
The Journal of Immunology. 204:231.31-231.31
Group B Streptococcus (GBS) is a major neonatal pathogen but rarely causes disease in adults. We previously showed in mice that GBS escapes killing in the neonatal lung via its heavily sialylated capsule. Immune cells detect sialic acid moieties via
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea975074a013a4d31e103f6c9180ad6e
https://doi.org/10.4049/jimmunol.204.supp.231.31
https://doi.org/10.4049/jimmunol.204.supp.231.31
Autor:
Asami Yamamura, Sean J Lund, Omar Lakhdari, Mashito Sakai, Christopher K Glass, Lawrence S Prince
Publikováno v:
The Journal of Immunology. 202:187.19-187.19
Neonates are uniquely susceptible to lung infection and injury. Alveolar (AM) and interstitial (IM) lung macrophages are the major cell populations protecting the lung against inhaled microbes and facilitating wound repair. AM and IM express unique c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d3abcdf7d8a610682a9b1ad88240a43
https://doi.org/10.4049/jimmunol.202.supp.187.19
https://doi.org/10.4049/jimmunol.202.supp.187.19
Autor:
Sean J Lund, Kathryn A Patras, Asami Yamamura, Gilberto Hernandez, Omar Lakhdari, Victor Nizet, Lawrence S Prince
Publikováno v:
The Journal of Immunology. 202:190.43-190.43
Group B Streptococcus (GBS) is the most common pathogen in neonates but rarely causes disease in adults. GBS causes pneumonia in newborns, suggesting a defect in lung innate immunity at birth. Using a novel neonatal mouse model of GBS pneumonia, we s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b0a1555d947c6513d7e33ae68bfbfd4
https://doi.org/10.4049/jimmunol.202.supp.190.43
https://doi.org/10.4049/jimmunol.202.supp.190.43
Autor:
Sean J. Lund, Kathryn A. Patras, Jacqueline M. Kimmey, Asami Yamamura, Gilberto Hernandez, Omar Lakhdari, Alyssa M. McCoy, Victor Nizet, Lawrence S. Prince
Publikováno v:
The Journal of Immunology. 200:117.30-117.30
Group B Streptococcus (Streptococcus agalactiae, GBS) causes severe infections in neonates. While not a common adult pathogen, GBS is the leading cause of congenital pneumonia. To determine the molecular mechanisms of neonatal susceptibility, we deve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::950f88ec38cd0f22f58270e479cd2fcd
https://doi.org/10.4049/jimmunol.200.supp.117.30
https://doi.org/10.4049/jimmunol.200.supp.117.30