Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Sean Hou"'
Autor:
Qiang Li, Fengbiao Mao, Bo Zhou, Yuanhao Huang, Zhenhua Zou, Aaron D. denDekker, Jing Xu, Sean Hou, Jie Liu, Yali Dou, Rajesh C. Rao
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 465-480.e6 (2020)
Summary: How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF,
Externí odkaz:
https://doaj.org/article/1e32d07bf5fe4e77a971975d984c9031
Autor:
Sara Venkatraman, Jesus Maria Gomez Salinero, Adina Scheinfeld, Sean Houghton, David Redmond, Monika Safford, Mangala Rajan
Publikováno v:
BMC Public Health, Vol 24, Iss 1, Pp 1-6 (2024)
Abstract Background Recent studies have demonstrated that individuals hospitalized due to COVID-19 can be affected by “long-COVID” symptoms for as long as one year after discharge. Objectives Our study objective is to identify data-driven cluster
Externí odkaz:
https://doaj.org/article/ba6d39703c024dbf8c2c25c78ee50a89
Autor:
Zhenhua Zou, Bo Zhou, Aaron denDekker, Qiang Li, Yali Dou, Rajesh C. Rao, Sean Hou, Fengbiao Mao, Jie Liu, Yuanhao Huang, Jing Xu
Publikováno v:
Cell Reports, Vol 30, Iss 2, Pp 465-480.e6 (2020)
Cell reports
Cell reports
SUMMARY How ubiquitous transcription factors (TFs) coordinate temporal inputs from broadly expressed epigenetic factors to control cell fate remains poorly understood. Here, we uncover a molecular relationship between p53, an abundant embryonic TF, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4aa9add1293f95c30f292276a1df2eb2
http://www.sciencedirect.com/science/article/pii/S2211124719316961
http://www.sciencedirect.com/science/article/pii/S2211124719316961
Autor:
Anjali Trivedi, Tyler M. Lu, Barbara Summers, Kihwan Kim, Alexander J. Rhee, Sean Houghton, Derek E. Byers, Raphaël Lis, Hasina Outtz Reed
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The lymphatic vasculature regulates lung homeostasis through drainage of fluid and trafficking of immune cells and plays a key role in the response to lung injury in several disease states. We have previously shown that lymphatic dysfunction occurs e
Externí odkaz:
https://doaj.org/article/0f6ab31e9e974b9483cfdb3150dfc7e5
Autor:
Aaron denDekker, Zhenhua Zou, Fengbiao Mao, Jing Xu, Yali Dou, Sean Hou, Qiang Li, Rajesh C. Rao
Publikováno v:
SSRN Electronic Journal.
Cell-type specific transcription factors cooperate with chromatin-modifying proteins to orchestrate proper differentiation, but little is known how ubiquitous embryonic proteins coordinate inputs from broadly expressed epigenetic factors to control c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::19030bcf2d0fba37cc2e30bc5dcec5a8
https://doi.org/10.2139/ssrn.3307529
https://doi.org/10.2139/ssrn.3307529
Autor:
José Gabriel Barcia Durán, Tyler Lu, Sean Houghton, Fuqiang Geng, Ryan Schreiner, Jenny Xiang, Shahin Rafii, David Redmond, Raphaël Lis
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Barcia Durán et al. show that the tyrosine kinase gene Jak3 is expressed in multiple endothelial cell types in the mouse, including in non-hematopoietic organs, with particularly high expression in the bone marrow. Using mice lacking Jak3, they show
Externí odkaz:
https://doaj.org/article/55bfd49a01c64b54879f2fc1d1c36b2b
Autor:
Lissenya B. Argueta, Lauretta A. Lacko, Yaron Bram, Takuya Tada, Lucia Carrau, André Figueiredo Rendeiro, Tuo Zhang, Skyler Uhl, Brienne C. Lubor, Vasuretha Chandar, Cristianel Gil, Wei Zhang, Brittany J. Dodson, Jeroen Bastiaans, Malavika Prabhu, Sean Houghton, David Redmond, Christine M. Salvatore, Yawei J. Yang, Olivier Elemento, Rebecca N. Baergen, Benjamin R. tenOever, Nathaniel R. Landau, Shuibing Chen, Robert E. Schwartz, Heidi Stuhlmann
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104223- (2022)
Summary: The effect of SARS-CoV-2 infection on placental function is not well understood. Analysis of placentas from women who tested positive at delivery showed SARS-CoV-2 genomic and subgenomic RNA in 22 out of 52 placentas. Placentas from two moth
Externí odkaz:
https://doaj.org/article/10e8c8bb49714f07ba4f189eb87775e5
Autor:
Jose M. Adrover, Lucia Carrau, Juliane Daßler-Plenker, Yaron Bram, Vasuretha Chandar, Sean Houghton, David Redmond, Joseph R. Merrill, Margaret Shevik, Benjamin R. tenOever, Scott K. Lyons, Robert E. Schwartz, Mikala Egeblad
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Severe acute lung injury has few treatment options and a high mortality rate. Upon injury, neutrophils infiltrate the lungs and form neutrophil extracellular traps (NETs), damaging the lungs and driving an exacerbated immune response. Unfortunately,
Externí odkaz:
https://doaj.org/article/12ddc5fdf3f044f9b0d26f8c3e6fe90c
Autor:
Tyler M. Lu, José Gabriel Barcia Durán, Sean Houghton, Shahin Rafii, David Redmond, Raphaël Lis
Publikováno v:
Frontiers in Physiology, Vol 12 (2021)
Brain microvascular endothelial cells (BMECs) possess unique properties that are crucial for many functions of the blood-brain-barrier (BBB) including maintenance of brain homeostasis and regulation of interactions between the brain and immune system
Externí odkaz:
https://doaj.org/article/66915dd315d74b8bba74f51c4754f1de
Autor:
Hyejin Choi, Jiehui Deng, Shuai Li, Tarik Silk, Lauren Dong, Elliott J. Brea, Sean Houghton, David Redmond, Hong Zhong, Jonathan Boiarsky, Esra A. Akbay, Paul D. Smith, Taha Merghoub, Kwok-Kin Wong, Jedd D. Wolchok
Publikováno v:
Cell Reports, Vol 27, Iss 3, Pp 806-819.e5 (2019)
Summary: KRAS is one of the driver oncogenes in non-small-cell lung cancer (NSCLC) but remains refractory to current modalities of targeted pathway inhibition, which include inhibiting downstream kinase MEK to circumvent KRAS activation. Here, we sho
Externí odkaz:
https://doaj.org/article/efa987c04f3a452490755f945bd7a287